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 Professor(Rockefeller University) Mailing address: Research Interests My research program addresses the general problem of predicting and manipulating protein-protein and protein-ligand interactions. I am specifically looking at these issues in voltage-gated ion channels, serotonin receptors and cadherins, families of membrane proteins that are amenable to powerful comparative analyses using machine learning techniques. These protein families are pivotal in the integrative metabolism of multicellular animals. They are also likely prospects for the rational development of nano-scale devices, including complex polyfunctional protein assemblages and specific biosensors. Selected Publications Montgomerie, S., Sundararaj, S., Gallin, W.J., and Wishart, D.S. (2006) Improving the accuracy of protein secondary structure prediction using structural alignment, BMC Bioinformatics, 7:301. Klassen, T.L., Buckingham, S.D., Atherton, D.M., Dacks, J.B., Gallin, W.J. and Spencer, A.N. (2006) Atypical Phenotypes from Flatworm Kv3 channels. Journal of Neurophysiology, 95: 3035-3046. Salvador-Recatala, V., Gallin, W.J., Abbruzzese, J., Ruben, P.C., and Spencer, A.N. (2006) A Kv4 channel cloned from the heart of the tunicate Ciona intestinalis and its modulation by a KChIP subunit, Journal of Experimental Biology, 209: 731-747 Li, B., and Gallin, W.J. (2005) Computational identification of residues that modulate voltage sensitivity of voltage-gated potassium channels. BMC Structural Biology, 5:16 Atkins, N.R., Gallin, W.J., Owens, G.C., Edelman, G.M., and Cunningham, B.A. (2004) N-CAM homophilic binding mediated by the two N-terminal Ig domains is influenced by intramolecular domain:domain interactions. Journal of Biological Chemistry, 279: 49633-49643 Doran, S.A., Koss, R., Tran, C.H., Christopher, K.J., Gallin, W.J., and Goldberg, J.I. (2004) Effect of serotonin on ciliary beating and intracellular calcium concentration in identified populations of embryonic ciliary cells. Journal of Experimental Biology 207:1415-1429 Li, B. and Gallin, W.J. (2004) VKCDB: Voltage-gated Potassium Channel DataBase. BMC Bioinformatics, 5:3 Atkins, N.R., Gallin, W.J., Owens, G.C., Edelman, G.M., and Cunningham, B.A., (2004) N-CAM homophilic binding mediated by the two N-terminal Ig domains is influenced by intramolecular domain:domain interactions. Journal of Biological Chemistry, 279: 49633-49643 Doran, S.A., Koss, R., Tran, C.H., Christopher, K.J., Gallin, W.J., and Goldberg, J.I. (2004) Effect of serotonin on ciliary beating and intracellular calcium concentration in identified populations of embryonic ciliary cells. Journal of Experimental Biology 207:1415-1429 Li, B. and Gallin, W.J. (2004) VKCDB: Voltage-gated Potassium Channel DataBase. BMC Bioinformatics, 5:3 Spafford, J.D., Munno, D.W., van Nierop, P., Feng, Z.P., Jarvis, S.E., Gallin, W.J., Smit, A.B., Zamponi, G.W., and Syed, N.I. (2002) A novel Renaud-Young, M. and Gallin, W.J. (2002) E-cadherin EC1: Heterophilic Interactions, but not the Conserved HAV Motif, are Required for Adhesion. Journal of Biological Chemistry, 277: 39609-39616 Li, B. and Gallin, W.J. (2002) Differential localization of chicken FIP2 homologue, Ag-9C5, in secretory epithelial cells. Experimental Cell Research, 272:135-145 Lin, Y.-C. J., Gallin, W.J. and Spencer, A.N. (2001) The anatomy of the Gallin, W.J. and Spencer, A.N. (2001) Evolution of Potassium Channels, |
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