Members of the Woodside team and Dept. of Physics during a workshop-retreat at Black Cat Guest Ranch near Hinton, AB (Feb 2014).Photo credit: Kamlesh Sahu
Selected Publications from the Woodside Lab


Single-molecule force spectroscopy of rapidly-fluctuating, marginally-stable structures in the intrinsically-disordered protein α-synuclein,” Allison Solanki, Krishna Neupane, Michael T. Woodside, Phys Rev Lett (in press)

"Measuring folding energy landscapes with single molecule force spectroscopy." M.T. Woodside, S.M. Block, Annu Rev Biophys, in press (2014).

"Anti-frameshifting ligand reduces the conformational plasticity of the SARS virus pseudoknot." D.B. Ritchie, J. Soong, W.K.A. Sikkema, M.T. Woodside, J Am Chem Soc, 136, 2196-2199 (2014). Link to   

"Diverse metastable structures formed by small oligomers of alpha-synuclein probed by force spectroscopy." K. Neupane, A. Solanki, I. Sosova, M. Belov, M.T. Woodside, PLoS One 9, e86495 (2014). Link to 


"Single-molecule assays for investigating protein misfolding and aggregation." A. Hoffmann, K. Neupane, M.T. Woodside, Phys Chem Chem Phys 15, 7934-7948 (2013). Link to manuscript.

"Single-molecule approaches to prion protein misfolding." H. Yu, D.R. Dee, M.T. Woodside, Prion 7, 140-146 (2013). Link to manuscript.


"Programmed -1 frameshifting efficiency correlates with RNA pseudoknot conformational plasticity, not resistance to mechanical unfolding." D.B. Ritchie, D.A.N. Foster, M.T. Woodside, Proc. Natl. Acad. Sci. USA 109, 16167-16172 (2012). Link to manuscript.

"Energy landscape analysis of native folding of the prion protein yields the diffusion constant, transition path time, and rates." H. Yu, A.N. Gupta, X. Liu, K. Neupane, A.M. Brigley, I. Sosova, M.T. Woodside, Proc. Natl. Acad. Sci. USA 109, 14452-14457 (2012). Link to manuscript.

"Transition path times for nucleic acid folding determined from energy-landscape analysis of single-molecule trajectories." K. Neupane, D.B. Ritchie, H. Yu, D.A.N. Foster, F. Wang, M.T. Woodside, Phys Rev Lett 109, 068102 (2012). Links to manuscript and Viewpointcommentary in Physics.

"Phthalocyanine tetrasulfonates bind to mulitple sites on natively-folded prion protein." D.R. Dee, A.N. Gupta, M. Anikovskiy, I. Sosova, E. Grandi, L. Rivera, A. Vincent, A.M. Brigley, N.O. Petersen, M.T. Woodside, BBA Proteins & Proteomics 1824, 826-832 (2012). Link to manuscript.

"Direct observation of multiple misfolding pathways in a single prion protein molecule." H. Yu, X. Liu, K. Neupane, A.N. Gupta, A.M. Brigley, A. Solanki, I. Sosova, M.T. Woodside, Proc. Natl. Acad. Sci. USA 109, 5283-5288 (2012). Link to manuscript.


"Signal-pair correlation analysis of single-molecule trajectories." A. Hoffmann, M.T. Woodside, Angew. Chem. Int. Ed. 50, 12643-12646 (2011). Links to manuscript and Highlight commentary in ChemPhysChem.

"Single-molecule force spectroscopy of the add adenine riboswitch relates folding to regulatory mechanism." K. Neupane, H. Yu, D.A.N. Foster, F. Wang, M.T. Woodside, Nucleic Acids Res 39, 7677-7687 (2011). PDF document.

"Experimental validation of free-energy-landscape reconstruction from non-equilibrium single-molecule force spectroscopy measurements." A.N. Gupta, A. Vincent, K. Neupane, H. Yu, F. Wang, M.T. Woodside, Nature Physics 7, 631-634 (2011). Links to manuscript andNews & Views commentary.

2005 - 2010

"Folding and unfolding single RNA molecules under tension." M.T. Woodside, C. Garcia-Garcia, S.M. Block, Curr. Opin. Chem. Biol. 12, 640-646 (2008). PDF document.

"Direct observation of hierarchical folding in single riboswitch aptamers." W.J. Greenleaf, K.L. Frieda, D.A.N. Foster, M.T. Woodside, S.M. Block,Science 319, 630-633 (2008). PDF document.

"High-resolution, single-molecule measurements of biomolecular motion." W.J. Greenleaf, M.T. Woodside, S.M. Block, Annu. Rev. Biophys. Biomol. Struct. 36, 171-190 (2007). PDF document.

"Direct measurement of the full, sequence-dependent folding landscape of a nucleic acid." M.T. Woodside, P.C. Anthony, K. Larizadeh, W.M. Behnke-Parks, D. Herschlag, S.M. Block, Science 314, 1001-1004 (2006). PDF document.

"Nanomechanical measurements of the sequence-dependent folding landscapes of single nucleic acid hairpins." M.T. Woodside, W.M. Behnke-Parks, K. Larizadeh, K. Travers, D. Herschlag, S.M. Block, Proc. Natl. Acad. Sci. USA 103, 6190-6195 (2006). PDF document.

"Passive all-optical force clamp for high-precision laser trapping." W.J. Greenleaf, M.T. Woodside, E.A. Abbondanzieri, S.M. Block,Phys. Rev. Lett. 95, 208102 (2005). PDF document.

2000 - 2005

"Scanned probe imaging of single-electron charge states in nanotube quantum dots." M.T. Woodside, P.L. McEuen, Science 296, 1098-1101 (2002). PDF document.

"Imaging inter edge state scattering centers in the quantum Hall regime." M.T. Woodside, C. Vale, P.L. McEuen, C. Kadow, K.D. Maranowski, A.C. Gossard, Phys. Rev. B 64, 041310 (2001). PDF document.