Table 1-1. Selected History of Contributions to Genetics

Year Researcher Contribution/Discovery
1865 Mendel Mendelian laws
1900 Correns, DeVries, Tschermak Rediscovery of Mendelian laws
1900 Landsteiner ABO blood group system
1908 Hardy & Weinburg Hardy-Weinburg law
1910-1920 Morgan Chromosome mapping in fruit flies
1941 Beadle & Tatum One gene, one enzyme
1942 Ford Genetic polymorphism
1949 Barr & Bertram Sex chromatin
1953 Watson & Crick Structure of DNA
1961 Lyon X-chromosome inactivation
1968-1970 Linn, Arber & Smith Restriction endonucleases (RE)
1971-1975 Nathans & Smith DNA characterization with RE
1975 Southern DNA blotting
1975-1977 Sanger & Gilbert DNA sequencing
1976 Tonegawa, et al. Somatic recombination in immunoglobulin genes
1984 Bishop & Varmus Oncogenes
1984 Gitschier, Toole, et al. Cloning of Factor VIII gene
1984-1985 Mullis, Saiki, et al. Polymerase chain reaction
1989 Collins, Riordan, Tsui, et al. Isolation of cystic fibrosis gene
1990 Yamamoto, et al. Cloning of the ABO genes

Historical Perspective Table 1-1