Located on Empress Road, St. Andrew's Church with its calm and quiet compound is a little further north of the Railway Headquarters and set back from the road. It is an attractive church built with mellow red Lahori brick. In contrast to its neighbor St. Anthony's across the road, St. Andrew's relies on Roman arched openings on the ground, while twin Romanesque windows adorn the belfry tower.

This octagonal tower punctured by Roman arch openings ends in a decorative flourish and a cupola. The pitched roofs of the nave and side ambulatory covered with simple metallic covering point towards an economical construction. Although originally the church came about as a result of a makeshift arrangement, the building is impressive in its simplicity and unadorned, unpretentious architectural character.

Before the current structure was built, the church was housed in the adjacent tomb of Muhammad Saleh Kamboh, the court chronicler of Emperor Shah Jahan, and his brother Inayatullah.