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Email: david.chang@ualberta.ca

Location of work: Chemical and Materials Engineering Building (Room 266A)- University of Alberta

Personal Details: I have an honours B.A.Sc. degree in Chemical Engineering from the University of Waterloo, in 2000. I also have an M.A.Sc. degree in Chemical Engineering from the University of Waterloo, in 2001. I am currently a Ph.D. candidate for Chemical and Materials Engineering at the University of Alberta. I also hold a contract research position with Chenomx Inc., in Edmonton, Alberta.

Research: My area of research is in the area of metabolomics. A significant challenge in metabolomics experiments is extracting biologically meaningful data from complex spectral information. The wealth of information contained within these spectra, are generated by very complex systems. My research involves understanding the mathematical principles behind the generation of this data, from the theoretical physics behind NMR experiments, to the digital signal processing of the digital data formats. Such that we can extract a meaningful mathematical model needed to represent this data in a consistent and useful state. At this stage, research is also done in finding appropriate classification models needed from a myriad of multivariate statistical models available to capture the information within the datasets. Finally, if one wishes to extract biological meaning behind these models, research is done to further examine the features that these models use in a systematic way.

Publications/Conferences:

1. D. Chang, A. Weljie, and J. Newton. (2007/) Leveraging Latent Information in NMR Spectra for Robust Predictive Models./ Jan. 3-7, 2007, Wailea, Maui, U.S.A. The Pacific Symposium on Biocomputing (submitted, refereed).

2. J. Newton, D. Chang, C. Smith, and A. Weljie. (2006/) Targeted Binning: A Novel Approach to Metabolomic Data Analysis./ June 25-29, 2006, Boston, MA, U.S.A. Metabolomics Society Meeting.

3. D. Chang, K.N. Rankin, A. McGeer, S.L. Shah, T.J. Marrie, and C.M. Slupsky. (2006/) Metabolite Profiles of Streptococcus pneumoniae Infections using ^1 H NMR Spectroscopy./ June 25-29, 2006, Boston, MA, U.S.A. Metabolomics Society Meeting.

4. D.Chang, C.M. Slupsky, T. Marrie, and S.L. Shah. (2005) /Metabolomics: Tools for Measuring Human Health/. Oct. 16-19, 2005, Toronto, Canada, Annual Meeting of the Canadian Society for Chemical Engineering.

5. E.J. Saude, D. Chang, C.M. Slupsky, D. Adamko, B. Rowe, S.L. Shah, and B.D. Sykes. (2005) /NMR-Based Metabolomic Investigation of Asthma and Therapeutic Response./ Jan. 29 - Feb. 4, 2005, Banff, Canada, Frontiers of NMR in Molecular Biology IX.

6. A. Weljie, D. Chang, J. Newton, E.J. Saude, B. Lix, B.D. Sykes, T.J. Marrie, C.M Slupsky, and S.L. Shah. (2005) /Metabolomic NMR Data Analysis in Human Disease./ Jan. 29 - Feb. 4, 2005, Banff, Canada, Frontiers of NMR in Molecular Biology IX.

7. D. Chang, E.J. Saude, C.M. Slupsky, B.D. Sykes, and S.L. Shah. (2004) /Multivariate Methods for Metabolomics./ December 13-14, 2004, Florida, U.S.A., Cambridge Healthtech Institute’s Fifth Annual, Metabolic Profiling: Pathways in Discovery.

8. D. Chang, E.J. Saude, B.D. Sykes, and S.L. Shah. (2004) /The Use of Metabolomics in the Study of Human Disease and Medicine./ Oct. 3-6, 2004, Calgary, Canada, Annual Meeting of the Canadian Society for Chemical Engineering.

9. D. Chang, and S.L. Shah. (2003) /Chemometric Data Analysis for Metabolomics./ Oct. 26-29, 2003, Hamilton, Canada, Annual Meeting of the Canadian Society for Chemical Engineering.