Division of
Experimental Surgery- Oncology and Transplantation
Ronald B.Moore M.D., Ph. D., FRCSC,
FACS
(Urology),
Translational
Research into Novel Strategies for Treating Bladder and Prostate Cancer
Our research focuses on novel modalities/therapeutics for treating bladder and prostate cancer. This research has included laser surgery (including PDT), development of lasers and light delivery/detection equipment, drug development, drug testing, drug delivery, biochemical and biological modifiers, molecular markers and predictive assays. These projects have required the development of in-vitro and in-vivo models that mimic the clinical entity being targeted. Our state of the art photobiology (chemistry and tissue culture) and laser (optics) laboratory is funded by peer reviewed grants and commercial contracts. In addition we utilize the core facilities at the Cross Cancer Institute and the Surgical Medical Research Institute. We have a multidisciplinary team consisting of biologists, chemists, physicists, engineers and physicians, with national and international collaborators. Currently we are investigating: the selective delivery of Hypocrellins and other second generation photosensitizers for the treatment of prostate cancer; reovirus and modifiers of the Epidermal Growth Factor Receptor (EGFR) pathway for treating bladder cancer; Tumor necrosis factor Related Apoptosis Inducing Ligand (TRAIL) and antisense Bcl-2 and Clusterin/TRPM-2 for treating bladder cancer; and the role of telomerase in apoptosis/senescence.
Mailing Address & Phone/Fax/E-Mail numbers
Dr. Ronald B. Moore
Division of Urology,
Department of Surgery
University of Alberta
2D2.16 Walter MacKenzie Center
8440-112 Street
Edmonton, Alberta T6G 2B7
office phone: (780)
407-6330
office fax: (780) 407-6331