Biochemistry

Faculty

Chris Bleackley Mechanisms of cell-mediated cytotoxicity and apoptosis
David Brindley Targeting the autotaxin-lysophosphatidate-inflammatory axis to improve cancer treatment
Joseph Casey
Bicarbonate transport in human disease
Michael Ellison
Mechanisms of cellular regulation
Richard Fahlman
Discovery of Novel Functions of small RNAs
Carlos Fernandez-Patron
Biology of matrix metalloproteinases (MMPs) in health and disease
Larry Fliegel
Regulation of intracellular pH via the Na+/H+ exchanger
Mark Glover
Mechanisms of regulation of gene expression
Ing Swie Goping
The role of mitochondria and the cytoskeleton in programmed cell death
Charles Holmes
Regulation of protein phosphatases and phosphorylation
Olivier Julien Using functional proteomics and structural biology to understand the role of proteases­­ in cell death and differentiation
Joanne Lemieux
Structural studies of membrane proteins associated with disease states
Bernard Lemire
The mitochondrial respiratory chain in disease and in aging
Andrew MacMillan
Chemical and biochemical mechanisms of RNA processing
Marek Michalak
Endoplasmic reticulum in health and disease
Sue-Ann Mok Deciphering the functional architecture of molecular chaperone networks
Michael Overduin Structural biology of signaling and trafficking
Michael Schultz
Regulation of transcription and chromatin assembly
Leo Spyracopoulos Structure and function of proteins involved in the protein ubiquitination pathway
David Stuart
Mechanisms of regulation of cell division
Brian Sykes
Structure, function and dynamics of muscle, prion, membrane, and antifreeze proteins
Nicolas Touret Molecular Cell Biology of Innate Immune Receptors
Dennis Vance
Molecular and cell biology of phospholipid biosynthesis and function
Holger Wille
Structural investigations of infectious prions and other misfolded proteins
Joel Weiner
Membrane protein structure and bioenergetics
Howard Young Regulation of calcium transport in heart disease
   
Emeriti
 
Michael James
Three-dimensional structure of proteins; hydrolytic mechanisms of proteinases
Cyril Kay
Muscle contraction/relaxation: Protein de novo design
Ronald MacElhaney
Roles of lipids in the structure and function of biological membranes
Paul Scott
Structure and function of extracellular matrix macromolecules
Jim Stone
Neoplastic transformation of cultured cells by dominant oncogenes
   
Adjunct
 
Shairaz Baksh
Common genetic immune system abnormalities found in Crohn’s, colitis and cancer, as well as early screening and treatment
Carol Cass
Nucleoside Transporter Proteins:   Studies of their Roles in Nucleoside Biology & Therapeutics
Rosalind Godbout
Regulation of gene expression in the developing retina and in retinoblastoma
Peter Hwang
(1) Developing solution NMR for large protein complexes and membrane proteins. (2)Targeting the cardiac troponin complex to understand and treat heart failure.
Rene Jacobs
Understand the complex interactions involved in the etiology of obesity, Diabetes and other chronic diseases
Liang Li
Analytical mass spectrometry (MS) for metabolomics and proteomics
Luis Schang
Protein kinases and other cellular factors in the replication and pathogenesis of viruses and prions
Lorne Tyrrell Study of hepatitis B virus (HBV) and hepatitis C virus (HCV)
David Westaway The use of genetically engineered “transgenic” mice to recreate and understand human neurologic disorders
Dawei Zhang
Regulation of cholesterol homeostasis