Ph.D, McGill University
Our overall goal is to characterize various conserved regulatory mechanisms that function in eukaryotes to ensure an appropriate gene expression response to internal and external cues. These studies are pursued using a model organism, budding yeast, and focus on events that occur in the nucleus. More details concerning our ongoing work can be found on the Schultz lab website.
Chromatin assembly in a crude fraction from yeast cells.
Robinson KM, Schultz MC.
Methods Mol Biol (2006) 313: 209-23.
A glycolytic burst drives glucose induction of global histone acetylation by picNuA4 and SAGA.
Friis RM, Wu BP, Reinke SN, Hockman DJ, Sykes BD, Schultz MC.
Nucleic Acids Res (2009) 37:3969-80.
Promoter regulation by distinct mechanisms of functional interplay between lysine acetylase Rtt109 and histone chaperone Asf1.
Lin LJ, Schultz MC.
PNAS (2011) 108: 19599-604.
Casein kinase II regulation of yeast TFIIIB is mediated by the TATA-binding protein.
Zaragoza D, Ghavidel A, Heitman J, Schultz MC.
Mol Cell Biol (1998) 18:4463-70.
TATA binding protein-associated CK2 transduces DNA damage signals to the RNA polymerase III transcriptional machinery.
Ghavidel A, Schultz, MC.
Cell (2001) 106:575-84.
Replication stress checkpoint signalling controls tRNA gene transcription.
Nguyen VC, Clelland BW, Hockman DJ, Kujat-Choy SL, Mewhort HE, Schultz MC.
Nature Struct & Mol Biol (2010) 17: 976-81.
Rewiring AMPK and mitochondrial retrograde signaling for metabolic control of aging and histone acetylation in respiratory-defective cells.
Friis RM, Glaves JP, Huan T, Li L, Sykes BD, Schultz MC.
Cell Reports (2014) 7: 565-74.