Biochemistry

Recent Publications

 

Tauroursodeoxycholic acid attenuates cyclosporine-induced renal fibrogenesis in the mouse model.
Groenendyk J, Robinson A, Wang Q, Hu M, Tang J, Chen XZ, Mengel M, Alexander RT, Agellon LB, Michalak M.
Biochim Biophys Acta Gen Subj. 2019 Jul;1863(7):1210-1216. doi: 10.1016/j.bbagen.2019.04.016. Epub 2019 Apr 24.

Role of N-glycosylation in the expression of human SLC26A2 and A3 anion transport membrane glycoproteins 1.
Rapp CL, Li J, Badior KE, Williams DB, Casey JR, Reithmeier RAF.
Biochem Cell Biol. 2019 Jun;97(3):290-306. doi: 10.1139/bcb-2018-0139. Epub 2018 Nov 21.

Structure and function of the Fgd family of divergent FYVE domain proteins 1.
Eitzen G, Smithers CC, Murray AG, Overduin M.
Biochem Cell Biol. 2019 Jun;97(3):257-264. doi: 10.1139/bcb-2018-0185. Epub 2018 Oct 11.

Molecular modeling and inhibitor docking analysis of the Na+/H+ exchanger isoform one 1.
Dutta D, Fliegel L.
Biochem Cell Biol. 2019 Jun;97(3):333-343. doi: 10.1139/bcb-2018-0158. Epub 2018 Jul 30.

Endoplasmic reticulum and the microRNA environment in the cardiovascular system 1.
Groenendyk J, Fan X, Peng Z, Kurgan L, Michalak M.
Can J Physiol Pharmacol. 2019 Jun;97(6):515-527. doi: 10.1139/cjpp-2018-0720. Epub 2019 May 7.

Pathologies of matrix metalloproteinase-2 underactivity: a perspective on a neglected condition 1.
Cook R, Sarker H, Fernandez-Patron C.
Can J Physiol Pharmacol. 2019 Jun;97(6):486-492. doi: 10.1139/cjpp-2018-0525. Epub 2018 Nov 20.

The human brain somatostatin interactome: SST binds selectively to P-type family ATPases.
Solarski M, Williams D, Mehrabian M, Wang H, Wille H, Schmitt-Ulms G.
PLoS One. 2019 May 28;14(5):e0217392. doi: 10.1371/journal.pone.0217392. eCollection 2019.

Label Free Proteomic Analysis Reveals Large Dynamic Changes to the Cellular Proteome Upon Expression of the miRNA-23a-27a-24-2 MicroRNA Cluster.
Piragasam RS, Hussain SF, Chaulk SG, Siddiqi ZA, Fahlman RP.
Biochem Cell Biol. 2019 May 16. doi: 10.1139/bcb-2019-0014. [Epub ahead of print]

When Degradation Elicits the Alarm: N-Terminal Degradation of NLRP1B Unleashes Its Inflammasome Activity.
Eldeeb MA, Fahlman RP, Esmaili M, Fon EA.
Mol Cell. 2019 May 16;74(4):637-639. doi: 10.1016/j.molcel.2019.04.032.

Prp8 in a Reduced Spliceosome Lacks a Conserved Toggle that Correlates with Splicing Complexity across Diverse Taxa.
Garside EL, Whelan TA, Stark MR, Rader SD, Fast NM, MacMillan AM.
J Mol Biol. 2019 May 9. pii: S0022-2836(19)30257-8. doi: 10.1016/j.jmb.2019.04.047. [Epub ahead of print]

Reactions at Biomembrane Interfaces.
Bondar AN, Lemieux MJ.
Chem Rev. 2019 May 8;119(9):6162-6183. doi: 10.1021/acs.chemrev.8b00596. Epub 2019 Apr 25.

Two pools of IRE1α in cardiac and skeletal muscle cells.
Wang Q, Groenendyk J, Paskevicius T, Qin W, Kor KC, Liu Y, Hiess F, Knollmann BC, Chen SRW, Tang J, Chen XZ, Agellon LB, Michalak M.
FASEB J. 2019 May 3:fj201802626R. doi: 10.1096/fj.201802626R. [Epub ahead of print]

Side-Chain Dynamics of the Trifluoroacetone Cysteine Derivative Characterized by 19F NMR Relaxation and Molecular Dynamics Simulations.
Rashid S, Lee BL, Wajda B, Spyracopoulos L.
J Phys Chem B. 2019 May 2;123(17):3665-3671. doi: 10.1021/acs.jpcb.9b01741. Epub 2019 Apr 22.

Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry.
Lapek JD Jr, Jiang Z, Wozniak JM, Arutyunova E, Wang SC, Lemieux MJ, Gonzalez DJ, O'Donoghue AJ.
Mol Cell Proteomics. 2019 May;18(5):968-981. doi: 10.1074/mcp.TIR118.001099. Epub 2019 Jan 31.

Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism.
Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS.
Oncogene. 2019 May;38(18):3325-3339. doi: 10.1038/s41388-018-0673-6. Epub 2019 Jan 11.

Nascent β Structure in the Elongated Hydrophobic Region of a Gerstmann-Sträussler-Scheinker PrP Allele.
Fu ZL, Holmes PC, Westaway D, Sykes BD.
J Mol Biol. 2019 Apr 26. pii: S0022-2836(19)30234-7. doi: 10.1016/j.jmb.2019.04.027. [Epub ahead of print]

Functional Analysis of Conserved Transmembrane Charged Residues and a Yeast Specific Extracellular Loop of the Plasma Membrane Na+/H+ Antiporter of Schizosaccharomyces pombe.
Dutta D, Ullah A, Bibi S, Fliegel L.
Sci Rep. 2019 Apr 17;9(1):6191. doi: 10.1038/s41598-019-42658-0.

Interrelations of Sphingolipid and Lysophosphatidate Signaling with Immune System in Ovarian Cancer.
Meshcheryakova A, Svoboda M, Jaritz M, Mungenast F, Salzmann M, Pils D, Cacsire Castillo-Tong D, Hager G, Wolf A, Braicu EI, Sehouli J, Lambrechts S, Vergote I, Mahner S, Birner P, Zimmermann P, Brindley DN, Heinze G, Zeillinger R, Mechtcheriakova D.
Comput Struct Biotechnol J. 2019 Apr 10;17:537-560. doi: 10.1016/j.csbj.2019.04.004. eCollection 2019.

The Hsp90 Chaperone: 1H and 19F Dynamic Nuclear Magnetic Resonance Spectroscopy Reveals a Perfect Enzyme.
Lee BL, Rashid S, Wajda B, Wolmarans A, LaPointe P, Spyracopoulos L.
Biochemistry. 2019 Apr 9;58(14):1869-1877. doi: 10.1021/acs.biochem.9b00144. Epub 2019 Mar 22.

A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling.
van der Veen JN, Lingrell S, McCloskey N, LeBlond ND, Galleguillos D, Zhao YY, Curtis JM, Sipione S, Fullerton MD, Vance DE, Jacobs RL.
FASEB J. 2019 Apr;33(4):5045-5057. doi: 10.1096/fj.201802117R. Epub 2019 Jan 7.