Biochemistry

Recent Publications

 

Tauroursodeoxycholic acid acts via TGR5 receptor to facilitate DNA damage repair and improve early porcine embryo development.
Dicks N, Gutierrez K, Currin L, Priotto de Macedo M, Glanzner W, Michalak M, Agellon LB, Bordignon V.
Mol Reprod Dev. 2019 Dec 3. doi: 10.1002/mrd.23305. [Epub ahead of print]

α-Synuclein strains target distinct brain regions and cell types.
Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, Tandon A, Hyman BT, Wille H, Ingelsson M, Klenerman D, Watts JC.
Nat Neurosci. 2019 Dec 2. doi: 10.1038/s41593-019-0541-x. [Epub ahead of print]

Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle.
Meng G, Wuest M, Tang X, Dufour J, Zhao Y, Curtis JM, McMullen TPW, Murray D, Wuest F, Brindley DN.
Cancers (Basel). 2019 Nov 19;11(11). pii: E1816. doi: 10.3390/cancers11111816.

Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1.
Richards MA, Simon JN, Ma R, Loonat AA, Crabtree MJ, Paterson DJ, Fahlman RP, Casadei B, Fliegel L, Swietach P.
Cardiovasc Res. 2019 Nov 19. pii: cvz311. doi: 10.1093/cvr/cvz311. [Epub ahead of print]

STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I.
Zhou C, Qian X, Hu M, Zhang R, Liu N, Huang Y, Yang J, Zhang J, Bai H, Yang Y, Wang Y, Ali D, Michalak M, Chen XZ, Tang J.
Autophagy. 2019 Nov 7:1-21. doi: 10.1080/15548627.2019.1687212. [Epub ahead of print]

Defective cell adhesion function of solute transporter, SLC4A11, in endothelial corneal dystrophies.
Malhotra D, Jung M, Fecher-Trost C, Lovatt M, Peh GSL, Noskov S, Mehta JS, Zimmermann R, Casey JR.
Hum Mol Genet. 2019 Nov 6. pii: ddz259. doi: 10.1093/hmg/ddz259. [Epub ahead of print]

Expression and detergent free purification and reconstitution of the plant plasma membrane Na+/H+ antiporter SOS1 overexpressed in Pichia pastoris.
Dutta D, Esmaili M, Overduin MFliegel L.
Biochim Biophys Acta Biomembr. 2019 Oct 31:183111. doi: 10.1016/j.bbamem.2019.183111. [Epub ahead of print]

An RNA guanine quadruplex regulated pathway to TRAIL-sensitization by DDX21.
McRae EKS, Dupas SJ, Booy EP, Piragasam RS, Fahlman RP, McKenna SA.
RNA. 2019 Oct 25. pii: rna.072199.119. doi: 10.1261/rna.072199.119. [Epub ahead of print]

Fgd5 is a Rac1-specific Rho GEF that is selectively inhibited by aurintricarboxylic acid.
Park S, Guo Y, Negre J, Preto J, Smithers CC, Azad AK, Overduin M, Murray AG, Eitzen G.
Small GTPases. 2019 Oct 10:1-14. doi: 10.1080/21541248.2019.1674765. [Epub ahead of print]

Deciphering the activation and recognition mechanisms of Staphylococcus aureus response regulator ArlR.
Ouyang Z, Zheng F, Chew JY, Pei Y, Zhou J, Wen K, Han M, Lemieux MJ, Hwang PM, Wen Y.
Nucleic Acids Res. 2019 Dec 2;47(21):11418-11429. doi: 10.1093/nar/gkz891.

Transition of the prion protein from a structured cellular form (PrPC ) to the infectious scrapie agent (PrPSc ).
Baral PK, Yin J, Aguzzi A, James MNG.
Protein Sci. 2019 Dec;28(12):2055-2063. doi: 10.1002/pro.3735. Epub 2019 Oct 25. Review.

Does N-Terminal Protein Acetylation Lead to Protein Degradation?
Eldeeb MA, Fahlman RP, Ragheb MA, Esmaili M.
Bioessays. 2019 Nov;41(11):e1800167. doi: 10.1002/bies.201800167. Epub 2019 Sep 24

Avoiding raising the ire of IRE1α.
Agellon LB, Michalak M.
Cell Calcium. 2019 Nov;83:102056. doi: 10.1016/j.ceca.2019.102056. Epub 2019 Aug 8.
 

Transition of the prion protein from a structured cellular form (PrPC ) to the infectious scrapie agent (PrPSc ).
Baral PK, Yin J, Aguzzi A, James MNG.
Protein Sci. 2019 Oct 3. doi: 10.1002/pro.3735. [Epub ahead of print] Review.

Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance.
Wan S, van der Veen JN, Bakala N'Goma JC, Nelson RC, Vance DE, Jacobs RL.
FASEB J. 2019 Oct 1;33(10):10986-10995. doi: 10.1096/fj.201900679R. Epub 2019 Jul 24.

Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.
Zhou Y, Millott R, Kim HJ, Peng S, Edwards RA, Skene-Arnold T, Hammel M, Lees-Miller SP, Tainer JA, Holmes CFBGlover JNM.
Structure. 2019 Oct 1;27(10):1485-1496.e4. doi: 10.1016/j.str.2019.07.012. Epub 2019 Aug 8.

Structure Preview Article of Zhou et. al

Inhibition of autotaxin with GLPG1690 increases the efficacy of radiotherapy and chemotherapy in a mouse model of breast cancer.
Tang X, Wuest M, Benesch MG, Dufour J, Zhao Y, Curtis JM, Monjardet A, Heckmann B, Murray D, Wuest F, Brindley DN.
Mol Cancer Ther. 2019 Sep 23. pii: molcanther.0386.2019. doi: 10.1158/1535-7163.MCT-19-0386. [Epub ahead of print]

TIMAP inhibits endothelial myosin light chain phosphatase by competing with MYPT1 for the catalytic protein phosphatase 1 subunit PP1cβ.
Wang X, Obeidat M, Li L, Pasarj P, Aburahess S, Holmes CFB, Ballermann BJ.
J Biol Chem. 2019 Sep 6;294(36):13280-13291. doi: 10.1074/jbc.RA118.006075. Epub 2019 Jul 17.

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.
Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, Gestwicki JE, Xu K, Kosik KS, Gan L.
Neuron. 2019 Sep 4. pii: S0896-6273(19)30692-0. doi: 10.1016/j.neuron.2019.08.008. [Epub ahead of print]

Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.
Ganesan A, Ahmed M, Okoye I, Arutyunova E, Babu D, Turnbull WL, Kundu JK, Shields J, Agopsowicz KC, Xu L, Tabana Y, Srivastava N, Zhang G, Moon TC, Belovodskiy A, Hena M, Kandadai AS, Hosseini SN, Hitt M, Walker J, Smylie M, West FG, Siraki AG, Lemieux MJ, Elahi S, Nieman JA, Tyrrell DL, Houghton M, Barakat K.
Sci Rep. 2019 Aug 27;9(1):12392. doi: 10.1038/s41598-019-48826-6.

Targeting B7-1 in immunotherapy.
Chen R, Ganesan A, Okoye I, Arutyunova E, Elahi S, Lemieux MJ, Barakat K.
Med Res Rev. 2019 Aug 25. doi: 10.1002/med.21632. [Epub ahead of print] Review.

Protease Substrate Identification Using N-terminomics.
Luo SY, Araya LE, Julien O.
ACS Chem Biol. 2019 Aug 15. doi: 10.1021/acschembio.9b00398. [Epub ahead of print]

Increasing the low lipid phosphate phosphatase 1 activity in breast cancer cells decreases transcription by AP-1 and expressions of matrix metalloproteinases and cyclin D1/D3.
Tang X, McMullen TPW, Brindley DN.
Theranostics. 2019 Aug 14;9(21):6129-6142. doi: 10.7150/thno.37094. eCollection 2019.

Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischemia-reperfusion injury.
Roczkowsky A, Chan BYH, Lee TYT, Mahmud Z, Hartley B, Julien O, Armanious G, Young HS, Schulz R.
Cardiovasc Res. 2019 Aug 2. pii: cvz207. doi: 10.1093/cvr/cvz207. [Epub ahead of print]

Two pools of IRE1α in cardiac and skeletal muscle cells.
Wang Q, Groenendyk J, Paskevicius T, Qin W, Kor KC, Liu Y, Hiess F, Knollmann BC, Chen SRW, Tang J, Chen XZ, Agellon LB, Michalak M.
FASEB J. 2019 Aug;33(8):8892-8904. doi: 10.1096/fj.201802626R. Epub 2019 May 3.

Trimeric structure of the mouse Kupffer cell C-type lectin receptor Clec4f.
Ouyang Z, Felix J, Zhou J, Pei Y, Ma B, Hwang PM, Lemieux MJ, Gutsche I, Zheng F, Wen Y.
FEBS Lett. 2019 Aug 1. doi: 10.1002/1873-3468.13565. [Epub ahead of print]

Organellar Calcium Handling in the Cellular Reticular Network.
Wang WA, Agellon LB, Michalak M.
Cold Spring Harb Perspect Biol. 2019 Jul 29. pii: a038265. doi: 10.1101/cshperspect.a038265. [Epub ahead of print]

A molecular toolbox for studying protein degradation in mammalian cells.
Eldeeb MA, Siva-Piragasam R, Ragheb MA, Esmaili M, Salla M, Fahlman RP.
J Neurochem. 2019 Jul 29. doi: 10.1111/jnc.14838. [Epub ahead of print] Review.