Biochemistry

Recent Publications

 

Avoiding raising the ire of IRE1α.
Agellon LB, Michalak M.
Cell Calcium. 2019 Nov;83:102056. doi: 10.1016/j.ceca.2019.102056. Epub 2019 Aug 8.

Transition of the prion protein from a structured cellular form (PrPC ) to the infectious scrapie agent (PrPSc ).
Baral PK, Yin J, Aguzzi A, James MNG.
Protein Sci. 2019 Oct 3. doi: 10.1002/pro.3735. [Epub ahead of print] Review.

Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance.
Wan S, van der Veen JN, Bakala N'Goma JC, Nelson RC, Vance DE, Jacobs RL.
FASEB J. 2019 Oct 1;33(10):10986-10995. doi: 10.1096/fj.201900679R. Epub 2019 Jul 24.

Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.
Zhou Y, Millott R, Kim HJ, Peng S, Edwards RA, Skene-Arnold T, Hammel M, Lees-Miller SP, Tainer JA, Holmes CFBGlover JNM.
Structure. 2019 Oct 1;27(10):1485-1496.e4. doi: 10.1016/j.str.2019.07.012. Epub 2019 Aug 8.

Structure Preview Article of Zhou et. al

Does N-Terminal Protein Acetylation Lead to Protein Degradation?
Eldeeb MA, Fahlman RP, Ragheb MA, Esmaili M.
Bioessays. 2019 Sep 24:e1800167. doi: 10.1002/bies.201800167. [Epub ahead of print]

Inhibition of autotaxin with GLPG1690 increases the efficacy of radiotherapy and chemotherapy in a mouse model of breast cancer.
Tang X, Wuest M, Benesch MG, Dufour J, Zhao Y, Curtis JM, Monjardet A, Heckmann B, Murray D, Wuest F, Brindley DN.
Mol Cancer Ther. 2019 Sep 23. pii: molcanther.0386.2019. doi: 10.1158/1535-7163.MCT-19-0386. [Epub ahead of print]

TIMAP inhibits endothelial myosin light chain phosphatase by competing with MYPT1 for the catalytic protein phosphatase 1 subunit PP1cβ.
Wang X, Obeidat M, Li L, Pasarj P, Aburahess S, Holmes CFB, Ballermann BJ.
J Biol Chem. 2019 Sep 6;294(36):13280-13291. doi: 10.1074/jbc.RA118.006075. Epub 2019 Jul 17.

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.
Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, Gestwicki JE, Xu K, Kosik KS, Gan L.
Neuron. 2019 Sep 4. pii: S0896-6273(19)30692-0. doi: 10.1016/j.neuron.2019.08.008. [Epub ahead of print]

Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.
Ganesan A, Ahmed M, Okoye I, Arutyunova E, Babu D, Turnbull WL, Kundu JK, Shields J, Agopsowicz KC, Xu L, Tabana Y, Srivastava N, Zhang G, Moon TC, Belovodskiy A, Hena M, Kandadai AS, Hosseini SN, Hitt M, Walker J, Smylie M, West FG, Siraki AG, Lemieux MJ, Elahi S, Nieman JA, Tyrrell DL, Houghton M, Barakat K.
Sci Rep. 2019 Aug 27;9(1):12392. doi: 10.1038/s41598-019-48826-6.

Targeting B7-1 in immunotherapy.
Chen R, Ganesan A, Okoye I, Arutyunova E, Elahi S, Lemieux MJ, Barakat K.
Med Res Rev. 2019 Aug 25. doi: 10.1002/med.21632. [Epub ahead of print] Review.

Protease Substrate Identification Using N-terminomics.
Luo SY, Araya LE, Julien O.
ACS Chem Biol. 2019 Aug 15. doi: 10.1021/acschembio.9b00398. [Epub ahead of print]

Increasing the low lipid phosphate phosphatase 1 activity in breast cancer cells decreases transcription by AP-1 and expressions of matrix metalloproteinases and cyclin D1/D3.
Tang X, McMullen TPW, Brindley DN.
Theranostics. 2019 Aug 14;9(21):6129-6142. doi: 10.7150/thno.37094. eCollection 2019.

Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischemia-reperfusion injury.
Roczkowsky A, Chan BYH, Lee TYT, Mahmud Z, Hartley B, Julien O, Armanious G, Young HS, Schulz R.
Cardiovasc Res. 2019 Aug 2. pii: cvz207. doi: 10.1093/cvr/cvz207. [Epub ahead of print]

Two pools of IRE1α in cardiac and skeletal muscle cells.
Wang Q, Groenendyk J, Paskevicius T, Qin W, Kor KC, Liu Y, Hiess F, Knollmann BC, Chen SRW, Tang J, Chen XZ, Agellon LB, Michalak M.
FASEB J. 2019 Aug;33(8):8892-8904. doi: 10.1096/fj.201802626R. Epub 2019 May 3.

Trimeric structure of the mouse Kupffer cell C-type lectin receptor Clec4f.
Ouyang Z, Felix J, Zhou J, Pei Y, Ma B, Hwang PM, Lemieux MJ, Gutsche I, Zheng F, Wen Y.
FEBS Lett. 2019 Aug 1. doi: 10.1002/1873-3468.13565. [Epub ahead of print]

Organellar Calcium Handling in the Cellular Reticular Network.
Wang WA, Agellon LB, Michalak M.
Cold Spring Harb Perspect Biol. 2019 Jul 29. pii: a038265. doi: 10.1101/cshperspect.a038265. [Epub ahead of print]

A molecular toolbox for studying protein degradation in mammalian cells.
Eldeeb MA, Siva-Piragasam R, Ragheb MA, Esmaili M, Salla M, Fahlman RP.
J Neurochem. 2019 Jul 29. doi: 10.1111/jnc.14838. [Epub ahead of print] Review.