Biochemistry

Recent Publications

 

Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischemia-reperfusion injury.
Roczkowsky A, Chan BYH, Lee TYT, Mahmud Z, Hartley B, Julien O, Armanious G, Young HS, Schulz R.
Cardiovasc Res. 2019 Aug 2. pii: cvz207. doi: 10.1093/cvr/cvz207. [Epub ahead of print]

Two pools of IRE1α in cardiac and skeletal muscle cells.
Wang Q, Groenendyk J, Paskevicius T, Qin W, Kor KC, Liu Y, Hiess F, Knollmann BC, Chen SRW, Tang J, Chen XZ, Agellon LB, Michalak M.
FASEB J. 2019 Aug;33(8):8892-8904. doi: 10.1096/fj.201802626R. Epub 2019 May 3.

Trimeric structure of the mouse Kupffer cell C-type lectin receptor Clec4f.
Ouyang Z, Felix J, Zhou J, Pei Y, Ma B, Hwang PM, Lemieux MJ, Gutsche I, Zheng F, Wen Y.
FEBS Lett. 2019 Aug 1. doi: 10.1002/1873-3468.13565. [Epub ahead of print]

Organellar Calcium Handling in the Cellular Reticular Network.
Wang WA, Agellon LB, Michalak M.
Cold Spring Harb Perspect Biol. 2019 Jul 29. pii: a038265. doi: 10.1101/cshperspect.a038265. [Epub ahead of print]

A molecular toolbox for studying protein degradation in mammalian cells.
Eldeeb MA, Piragasam RS, Ragheb MA, Esmaili M, Salla M, Fahlman RP.
J Neurochem. 2019 Jul 29. doi: 10.1111/jnc.14838. [Epub ahead of print] Review.

Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance.
Wan S, van der Veen JN, Bakala N'Goma JC, Nelson RC, Vance DE, Jacobs RL.
FASEB J. 2019 Jul 24:fj201900679R. doi: 10.1096/fj.201900679R. [Epub ahead of print]

TIMAP inhibits endothelial myosin light chain phosphatase by competing with MYPT1 for the catalytic protein phosphatase 1 subunit PP1cβ.
Wang X, Obeidat M, Li L, Pasarj P, Aburahess S, Holmes CFB, Ballermann BJ.
J Biol Chem. 2019 Jul 17. pii: jbc.RA118.006075. doi: 10.1074/jbc.RA118.006075. [Epub ahead of print]

Human Corneal Expression of SLC4A11, a Gene Mutated in Endothelial Corneal Dystrophies.
Malhotra D, Loganathan SK, Chiu AM, Lukowski CM, Casey JR.
Sci Rep. 2019 Jul 4;9(1):9681. doi: 10.1038/s41598-019-46094-y.

Feasibility of trifluoromethyl TROSY NMR at high magnetic fields.
Klein BA, Sykes BD.
J Biomol NMR. 2019 Jul 2. doi: 10.1007/s10858-019-00266-0. [Epub ahead of print]

Tauroursodeoxycholic acid attenuates cyclosporine-induced renal fibrogenesis in the mouse model.
Groenendyk J, Robinson A, Wang Q, Hu M, Tang J, Chen XZ, Mengel M, Alexander RT, Agellon LB, Michalak M.
Biochim Biophys Acta Gen Subj. 2019 Jul;1863(7):1210-1216. doi: 10.1016/j.bbagen.2019.04.016. Epub 2019 Apr 24.

Prp8 in a Reduced Spliceosome Lacks a Conserved Toggle that Correlates with Splicing Complexity across Diverse Taxa.
Garside EL, Whelan TA, Stark MR, Rader SD, Fast NM, MacMillan AM.
J Mol Biol. 2019 Jun 28;431(14):2543-2553. doi: 10.1016/j.jmb.2019.04.047. Epub 2019 May 9.

Nascent β Structure in the Elongated Hydrophobic Region of a Gerstmann-Sträussler-Scheinker PrP Allele.
Fu ZL, Holmes PC, Westaway D, Sykes BD.
J Mol Biol. 2019 Jun 28;431(14):2599-2611. doi: 10.1016/j.jmb.2019.04.027. Epub 2019 Apr 26.

Structures and Interactions of Transmembrane Targets in Native Nanodiscs.
Overduin M, Esmaili M.
SLAS Discov. 2019 Jun 26:2472555219857691. doi: 10.1177/2472555219857691. [Epub ahead of print]

JoVE Methods Collection Highlights: Protein-Protein Interactions.
Barr A, Overduin M.
J Vis Exp. 2019 Jun 10;(148). doi: 10.3791/59816.

Emerging pathways of communication between the heart and non-cardiac organs.
Hardy-Rando E, Fernandez-Patron C.
J Biomed Res. 2019 Jun 4;33(3):145-155. doi: 10.7555/JBR.32.20170137.

Role of N-glycosylation in the expression of human SLC26A2 and A3 anion transport membrane glycoproteins 1.
Rapp CL, Li J, Badior KE, Williams DB, Casey JR, Reithmeier RAF.
Biochem Cell Biol. 2019 Jun;97(3):290-306. doi: 10.1139/bcb-2018-0139. Epub 2018 Nov 21.

Structure and function of the Fgd family of divergent FYVE domain proteins 1.
Eitzen G, Smithers CC, Murray AG, Overduin M.
Biochem Cell Biol. 2019 Jun;97(3):257-264. doi: 10.1139/bcb-2018-0185. Epub 2018 Oct 11.

Molecular modeling and inhibitor docking analysis of the Na+/H+ exchanger isoform one 1.
Dutta D, Fliegel L.
Biochem Cell Biol. 2019 Jun;97(3):333-343. doi: 10.1139/bcb-2018-0158. Epub 2018 Jul 30.

Endoplasmic reticulum and the microRNA environment in the cardiovascular system 1.
Groenendyk J, Fan X, Peng Z, Kurgan L, Michalak M.
Can J Physiol Pharmacol. 2019 Jun;97(6):515-527. doi: 10.1139/cjpp-2018-0720. Epub 2019 May 7.

Pathologies of matrix metalloproteinase-2 underactivity: a perspective on a neglected condition 1.
Cook R, Sarker H, Fernandez-Patron C.
Can J Physiol Pharmacol. 2019 Jun;97(6):486-492. doi: 10.1139/cjpp-2018-0525. Epub 2018 Nov 20.

The human brain somatostatin interactome: SST binds selectively to P-type family ATPases.
Solarski M, Williams D, Mehrabian M, Wang H, Wille H, Schmitt-Ulms G.
PLoS One. 2019 May 28;14(5):e0217392. doi: 10.1371/journal.pone.0217392. eCollection 2019.

Label Free Proteomic Analysis Reveals Large Dynamic Changes to the Cellular Proteome Upon Expression of the miRNA-23a-27a-24-2 MicroRNA Cluster.
Piragasam RS, Hussain SF, Chaulk SG, Siddiqi ZA, Fahlman RP.
Biochem Cell Biol. 2019 May 16. doi: 10.1139/bcb-2019-0014. [Epub ahead of print]

When Degradation Elicits the Alarm: N-Terminal Degradation of NLRP1B Unleashes Its Inflammasome Activity.
Eldeeb MA, Fahlman RP, Esmaili M, Fon EA.
Mol Cell. 2019 May 16;74(4):637-639. doi: 10.1016/j.molcel.2019.04.032.

Reactions at Biomembrane Interfaces.
Bondar AN, Lemieux MJ.
Chem Rev. 2019 May 8;119(9):6162-6183. doi: 10.1021/acs.chemrev.8b00596. Epub 2019 Apr 25.

Two pools of IRE1α in cardiac and skeletal muscle cells.
Wang Q, Groenendyk J, Paskevicius T, Qin W, Kor KC, Liu Y, Hiess F, Knollmann BC, Chen SRW, Tang J, Chen XZ, Agellon LB, Michalak M.
FASEB J. 2019 May 3:fj201802626R. doi: 10.1096/fj.201802626R. [Epub ahead of print]

Side-Chain Dynamics of the Trifluoroacetone Cysteine Derivative Characterized by 19F NMR Relaxation and Molecular Dynamics Simulations.
Rashid S, Lee BL, Wajda B, Spyracopoulos L.
J Phys Chem B. 2019 May 2;123(17):3665-3671. doi: 10.1021/acs.jpcb.9b01741. Epub 2019 Apr 22.

Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry.
Lapek JD Jr, Jiang Z, Wozniak JM, Arutyunova E, Wang SC, Lemieux MJ, Gonzalez DJ, O'Donoghue AJ.
Mol Cell Proteomics. 2019 May;18(5):968-981. doi: 10.1074/mcp.TIR118.001099. Epub 2019 Jan 31.

Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism.
Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS.
Oncogene. 2019 May;38(18):3325-3339. doi: 10.1038/s41388-018-0673-6. Epub 2019 Jan 11.