Recent Publications


Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice.
Presa N, Clugston RD, Lingrell S, Kelly SE, Merrill AH Jr, Jana S, Kassiri Z, Gómez-Muñoz A, Vance DE, Jacobs RL, van der Veen JN.
Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):14-25. doi: 10.1016/j.bbadis.2018.10.010. Epub 2018 Oct 6.

Understanding Conformational Dynamics of Complex Lipid Mixtures Relevant to Biology.
Friedman R, Khalid S, Aponte-Santamaría C, Arutyunova E, Becker M, Boyd KJ, Christensen M, Coimbra JTS, Concilio S, Daday C, van Eerden FJ, Fernandes PA, Gräter F, Hakobyan D, Heuer A, Karathanou K, Keller F, Lemieux MJ, Marrink SJ, May ER, Mazumdar A, Naftalin R, Pickholz M, Piotto S, Pohl P, Quinn P, Ramos MJ, Schiøtt B, Sengupta D, Sessa L, Vanni S, Zeppelin T, Zoni V, Bondar AN, Domene C.
J Membr Biol. 2018 Dec;251(5-6):609-631. doi: 10.1007/s00232-018-0050-y. Epub 2018 Oct 22. Review.

Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.
Zhang P, Csaki LS, Ronquillo E, Baufeld LJ, Lin JY, Gutierrez A, Dwyer JR, Brindley DN, Fong LG, Tontonoz P, Young SG, Reue K.
J Clin Invest. 2018 Dec 3. pii: 122595. doi: 10.1172/JCI122595. [Epub ahead of print]

Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers.
MacFawn I, Wilson H, Selth LA, Leighton I, Serebriiskii I, Bleackley RC, Elzamzamy O, Farris J, Pifer PM, Richer J, Frisch SM.
Mol Immunol. 2018 Nov 30;105:137-149. doi: 10.1016/j.molimm.2018.11.006. [Epub ahead of print]

Memtein: The fundamental unit of membrane-protein structure and function.
Overduin M, Esmaili M.
Chem Phys Lipids. 2018 Nov 30;218:73-84. doi: 10.1016/j.chemphyslip.2018.11.008. [Epub ahead of print] Review.

Highlight: Frontiers in Proteolysis.
Lemieux MJ, Denault JB, Overall CM.
Biol Chem. 2018 Nov 27;399(12):1351. doi: 10.1515/hsz-2018-0401. No abstract available.

An internally quenched peptide as a new model substrate for rhomboid intramembrane proteases.
Arutyunova E, Jiang Z, Yang J, Kulepa AN, Young HS, Verhelst S, O'Donoghue AJ, Lemieux MJ.
Biol Chem. 2018 Nov 27;399(12):1389-1397. doi: 10.1515/hsz-2018-0255.

Role of N-glycosylation in the expression of human SLC26A2 and A3 anion transport membrane glycoproteins.
Rapp CL, Li J, Badior KE, Williams DB, Casey JR, Reithmeier RAF.
Biochem Cell Biol. 2018 Nov 21. doi: 10.1139/bcb-2018-0139. [Epub ahead of print]

Stress Coping Strategies in the Heart: An Integrated View.
Michalak M, Agellon LB.
Front Cardiovasc Med. 2018 Nov 21;5:168. doi: 10.3389/fcvm.2018.00168. eCollection 2018. Review.

Structural Changes Induced by the Binding of the Calcium Desensitizer W7 to Cardiac Troponin.
Cai F, Hwang PM, Sykes BD.
Biochemistry. 2018 Nov 20;57(46):6461-6469. doi: 10.1021/acs.biochem.8b00882. Epub 2018 Nov 6.

Pathologies of MMP-2 underactivity: A perspective on a neglected condition.
Cook RN, Sarker H, Fernandez-Patron C.
Can J Physiol Pharmacol. 2018 Nov 20. doi: 10.1139/cjpp-2018-0525. [Epub ahead of print]

Domain analysis of PNKP/XRCC1 interactions: influence of genetic variants of XRCC1.
Mani RS, Mermershtain I, Abdou I, Fanta M, Hendzel MJ, Glover JNM, Weinfeld M.
J Biol Chem. 2018 Nov 16. pii: jbc.RA118.004262. doi: 10.1074/jbc.RA118.004262. [Epub ahead of print]

Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70.
Forero-Quintero LS, Ames S, Schneider HP, Thyssen A, Boone CD, Andring JT, McKenna R, Casey JR, Deitmer JW, Becker HM.
J Biol Chem. 2018 Nov 16. pii: jbc.RA118.005536. doi: 10.1074/jbc.RA118.005536. [Epub ahead of print]

Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor.
Groenendyk J, Paskevicius T, Urra H, Viricel C, Wang K, Barakat K, Hetz C, Kurgan L, Agellon LB, Michalak M.
Sci Rep. 2018 Nov 12;8(1):16678. doi: 10.1038/s41598-018-34891-w.

Intrinsic disorder in the regulatory N-terminal domain of diacylglycerol acyltransferase 1 from Brassica napus.
Panigrahi R, Matsui T, Song AH, Caldo KMP, Young HS, Weselake RJ, Lemieux MJ.
Sci Rep. 2018 Nov 12;8(1):16665. doi: 10.1038/s41598-018-34339-1.

Endoplasmic reticulum calcium dictates the distribution of intracellular unesterified cholesterol.
Wang WA, Agellon LB, Michalak M.
Cell Calcium. 2018 Nov 10;76:116-121. doi: 10.1016/j.ceca.2018.11.002. [Epub ahead of print] Review.

Structural Studies of Macromolecules in Solution using Small Angle X-Ray Scattering.
Mrozowich T, McLennan S, Overduin M, Patel TR.
J Vis Exp. 2018 Nov 5;(141). doi: 10.3791/58538.

Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy (NMR) and Microscale Thermophoresis (MST).
Winkelaar G, Trieber C, Kumar J, Overduin M.
J Vis Exp. 2018 Nov 2;(141). doi: 10.3791/58537.

The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C.
Li MX, Gelozia S, Danmaliki GI, Wen Y, Liu PB, Lemieux MJ, West FG, Sykes BD, Hwang PM.
Biochem Biophys Rep. 2018 Nov 1;16:145-151. doi: 10.1016/j.bbrep.2018.10.012. eCollection 2018 Dec.

Erratum to Residue-specific mobility changes in soluble oligomers of the prion protein define regions involved in aggregation, BBAPAP (2018) 982-988.
Glaves JP, Ladner-Keay CL, Bjorndahl TC, Wishart DS, Sykes BD.
Biochim Biophys Acta Proteins Proteom. 2018 Nov;1866(11):1199-1200. doi: 10.1016/j.bbapap.2018.07.008. Epub 2018 Aug 1. No abstract available.

Regulating Apoptosis by Degradation: The N-End Rule-Mediated Regulation of Apoptotic Proteolytic Fragments in Mammalian Cells.
Eldeeb MA, Fahlman RP, Esmaili M, Ragheb MA.
Int J Mol Sci. 2018 Oct 31;19(11). pii: E3414. doi: 10.3390/ijms19113414. Review.

Dynamics-Derived Insights into Complex Formation between the CXCL8 Monomer and CXCR1 N-Terminal Domain: An NMR Study.
Joseph PRB, Spyracopoulos L, Rajarathnam K.
Molecules. 2018 Oct 31;23(11). pii: E2825. doi: 10.3390/molecules23112825.

Cooperative function of TraJ and ArcA in regulating the F plasmid tra operon.
Lu J, Peng Y, Wan S, Frost LS, Raivio T, Glover JNM.
J Bacteriol. 2018 Oct 15. pii: JB.00448-18. doi: 10.1128/JB.00448-18. [Epub ahead of print]

Structure and function of the Fgd family of divergent FYVE domain proteins.
Eitzen G, Smithers CC, Murray AG, Overduin M.
Biochem Cell Biol. 2018 Oct 11:1-8. doi: 10.1139/bcb-2018-0185. [Epub ahead of print]

Diacylglycerol acyltransferase 1 is activated by phosphatidate and inhibited by SnRK1-catalyzed phosphorylation.
Caldo KMP, Shen W, Xu Y, Hanley-Bowdoin L, Chen G, Weselake RJ, Lemieux MJ.
Plant J. 2018 Oct;96(2):287-299. doi: 10.1111/tpj.14029. Epub 2018 Aug 24.

The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins.
Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA.
ACS Chem Biol. 2018 Sep 21;13(9):2398-2405. doi: 10.1021/acschembio.8b00508. Epub 2018 Aug 14.

Lipomyces starkeyi: an emerging cell factory for production of lipids, oleochemicals and biotechnology applications.
McNeil BA, Stuart DT.
World J Microbiol Biotechnol. 2018 Sep 12;34(10):147. doi: 10.1007/s11274-018-2532-6. Review.

Dexamethasone decreases the autotaxin-lysophosphatidate-inflammatory axis in adipose tissue: implications for the metabolic syndrome and breast cancer.
Meng G, Tang X, Yang Z, Zhao Y, Curtis JM, McMullen TPW, Brindley DN.
FASEB J. 2018 Sep 7:fj201801226R. doi: 10.1096/fj.201801226R. [Epub ahead of print]

Properties and Biotechnological Applications of Acyl-CoA:diacylglycerol Acyltransferase and Phospholipid:diacylglycerol Acyltransferase from Terrestrial Plants and Microalgae.
Xu Y, Caldo KMP, Pal-Nath D, Ozga J, Lemieux MJ, Weselake RJ, Chen G.
Lipids. 2018 Jul;53(7):663-688. doi: 10.1002/lipd.12081. Epub 2018 Sep 25. Review.