Recent Publications

Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation.
Daude N, Kim C, Kang SG, Eskandari-Sedighi G, Haldiman T, Yang J, Fleck SC, Gomez-Cardona E, Han ZZ, Borrego-Ecija S, Wohlgemuth S, Julien O, Wille H, Molina-Porcel L, Gelpi E, Safar JG, Westaway D.
Acta Neuropathol. 2020 Mar 26. doi: 10.1007/s00401-020-02148-4. [Epub ahead of print]

Characterization of multimeric daptomycin bound to lipid nanodiscs formed by calcium-tolerant styrene-maleic acid copolymer.
Beriashvili D, Spencer NR, Dieckmann T, Overduin M, Palmer M.
Biochim Biophys Acta Biomembr. 2020 Mar 5;1862(6):183234. doi: 10.1016/j.bbamem.2020.183234. [Epub ahead of print]

Acidic residues of extracellular loop 3 of the Na+/H+ exchanger type 1 are important in cation transport.
Li X, Quan S, Corsiatto T, Fliegel L.
Mol Cell Biochem. 2020 Mar 4. doi: 10.1007/s11010-020-03707-9. [Epub ahead of print]

SLC26A7 protein is a chloride/bicarbonate exchanger and its abundance is osmolarity- and pH-dependent in renal epithelial cells.
Ullah AKMS, Rumley AC, Peleh V, Fernandes D, Almomani EY, Berrini M, Lashhab R, Touret N, Alexander RT, Herrmann JM, Cordat E.
Biochim Biophys Acta Biomembr. 2020 Feb 28;1862(6):183238. doi: 10.1016/j.bbamem.2020.183238. [Epub ahead of print]

Destroy to Rebuild: The Connection Between Bone Tissue Remodeling and Matrix Metalloproteinases.
Hardy E, Fernandez-Patron C.
Front Physiol. 2020 Feb 5;11:47. doi: 10.3389/fphys.2020.00047. eCollection 2020. Review.

Expression and detergent free purification and reconstitution of the plant plasma membrane Na+/H+ antiporter SOS1 overexpressed in Pichia pastoris.
Dutta D, Esmaili M, Overduin M, Fliegel L.
Biochim Biophys Acta Biomembr. 2020 Mar 1;1862(3):183111. doi: 10.1016/j.bbamem.2019.183111. Epub 2019 Oct 31.

Targeting B7-1 in immunotherapy.
Chen R, Ganesan A, Okoye I, Arutyunova E, Elahi S, Lemieux MJ, Barakat K.
Med Res Rev. 2020 Mar;40(2):654-682. doi: 10.1002/med.21632. Epub 2019 Aug 25. Review.

Binding of the periplakin linker requires vimentin acidic residues D176 and E187.
Odintsova E, Mohammed F, Trieber C, Rodriguez-Zamora P, Al-Jassar C, Huang TH, Fogl C, Knowles T, Sridhar P, Kumar J, Jeeves M, Chidgey M, Overduin M.
Commun Biol. 2020 Feb 21;3(1):83. doi: 10.1038/s42003-020-0810-y.

Addressing Ligand-Based Redox in Molybdenum-Dependent Methionine Sulfoxide Reductase.
Ingersol LJ, Yang J, Kc K, Pokhrel A, Astashkin AV, Weiner JH, Johnston CA, Kirk ML.
J Am Chem Soc. 2020 Feb 12;142(6):2721-2725. doi: 10.1021/jacs.9b11762. Epub 2020 Jan 28.

Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae.
Benesch MGK, Tang X, Brindley DN.
Cancers (Basel). 2020 Feb 6;12(2). pii: E374. doi: 10.3390/cancers12020374. Review.

Label-free proteomic analysis reveals large dynamic changes to the cellular proteome upon expression of the miRNA-23a-27a-24-2 microRNA cluster.
Piragasam RS, Hussain SF, Chaulk SG, Siddiqi ZA, Fahlman RP.
Biochem Cell Biol. 2020 Feb;98(1):61-69. doi: 10.1139/bcb-2019-0014. Epub 2019 May 16.

Interaction of a Sarcolipin Pentamer and Monomer with the Sarcoplasmic Reticulum Calcium Pump, SERCA.
Glaves JP, Primeau JO, Gorski PA, Espinoza-Fonseca LM, Lemieux MJ, Young HS.
Biophys J. 2020 Jan 21;118(2):518-531. doi: 10.1016/j.bpj.2019.11.3385. Epub 2019 Nov 28.

BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis.
Mann J, Yang N, Montpetit R, Kirschenman R, Lemieux H, Goping IS.
Sci Rep. 2020 Jan 15;10(1):355. doi: 10.1038/s41598-019-57282-1.

Trimeric structure of the mouse Kupffer cell C-type lectin receptor Clec4f.
Ouyang Z, Felix J, Zhou J, Pei Y, Ma B, Hwang PM, Lemieux MJ, Gutsche I, Zheng F, Wen Y.
FEBS Lett. 2020 Jan;594(1):189-198. doi: 10.1002/1873-3468.13565. Epub 2019 Aug 9.

Defective cell adhesion function of solute transporter, SLC4A11, in endothelial corneal dystrophies.
Malhotra D, Jung M, Fecher-Trost C, Lovatt M, Peh GSL, Noskov S, Mehta JS, Zimmermann R, Casey JR.
Hum Mol Genet. 2020 Jan 1;29(1):97-116. doi: 10.1093/hmg/ddz259.

Optimizing fluorine labelling for 19F solid-state NMR in oriented biological systems.
Robertson IM, Klein BA, Sykes BD.
J Biomol NMR. 2020 Jan;74(1):1-7. doi: 10.1007/s10858-019-00296-8. Epub 2020 Jan 7.

Biochemical Methods for the Study of the FinO Family of Bacterial RNA Chaperones.
Kim HJ, Chaulk S, Arthur D, Edwards RA, Glover JNM.
Methods Mol Biol. 2020;2106:1-18. doi: 10.1007/978-1-0716-0231-7_1.

Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer.
Tang X, Wuest M, Benesch MGK, Dufour J, Zhao Y, Curtis JM, Monjardet A, Heckmann B, Murray D, Wuest F, Brindley DN.
Mol Cancer Ther. 2020 Jan;19(1):63-74. doi: 10.1158/1535-7163.MCT-19-0386. Epub 2019 Sep 23.

Tauroursodeoxycholic acid acts via TGR5 receptor to facilitate DNA damage repair and improve early porcine embryo development.
Dicks N, Gutierrez K, Currin L, Priotto de Macedo M, Glanzner W, Michalak M, Agellon LB, Bordignon V.
Mol Reprod Dev. 2020 Jan;87(1):161-173. doi: 10.1002/mrd.23305. Epub 2019 Dec 3.

α-Synuclein strains target distinct brain regions and cell types.
Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, Tandon A, Hyman BT, Wille H, Ingelsson M, Klenerman D, Watts JC.
Nat Neurosci. 2020 Jan;23(1):21-31. doi: 10.1038/s41593-019-0541-x. Epub 2019 Dec 2.

An RNA guanine quadruplex regulated pathway to TRAIL-sensitization by DDX21.
McRae EKS, Dupas SJ, Booy EP, Piragasam RS, Fahlman RP, McKenna SA.
RNA. 2020 Jan;26(1):44-57. doi: 10.1261/rna.072199.119. Epub 2019 Oct 25.