Recent Publications

 

Calsequestrin. Structure, function, and evolution.
Wang Q, Michalak M.
Cell Calcium. 2020 Jun 20;90:102242. doi: 10.1016/j.ceca.2020.102242. [Epub ahead of print]

Protein docking and steered molecular dynamics suggest alternative phospholamban-binding sites on the SERCA calcium transporter.
Alford RF, Smolin N, Young HS, Gray JJ, Robia SL.
J Biol Chem. 2020 Jun 17. pii: jbc.RA120.012948. doi: 10.1074/jbc.RA120.012948. [Epub ahead of print]

Backbone resonance assignments of the catalytic and regulatory domains of Ca2+/calmodulin-dependent protein kinase 1D.
Tong MHG, Jeeves M, Rajesh S, Ludwig C, Lenoir M, Kumar J, McClelland DM, Berditchevski F, Hubbard JA, Kenyon C, Butterworth S, Knapp S, Overduin M.
Biomol NMR Assign. 2020 Jun 13. doi: 10.1007/s12104-020-09950-x. [Epub ahead of print]

Metabolomic study of disease progression in scrapie prion infected mice; validation of a novel method for brain metabolite extraction.
Fu ZL, Mercier P, Eskandari-Sedighi G, Yang J, Westaway D, Sykes BD.
Metabolomics. 2020 Jun 12;16(6):72. doi: 10.1007/s11306-020-01690-2.

The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.
Sanderson MR, Badior KE, Fahlman RP, Wevrick R.
Hum Genet. 2020 Jun 11. doi: 10.1007/s00439-020-02193-9. [Epub ahead of print]

BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancer.
Pandya V, Githaka JM, Patel N, Veldhoen R, Hugh J, Damaraju S, McMullen T, Mackey J, Goping IS.
Cell Death Dis. 2020 Jun 11;11(6):448. doi: 10.1038/s41419-020-2654-2.

In vitro Treatment of a Murine Mammary Adenocarcinoma Cell Line with Recombinant Trypanosoma cruzi Calreticulin Promotes Immunogenicity and Phagocytosis.
Sosoniuk-Roche E, Cruz P, Maldonado I, Duaso L, Pesce B, Michalak M, Valck C, Ferreira A.
Mol Immunol. 2020 Jun 8;124:51-60. doi: 10.1016/j.molimm.2020.05.013. [Epub ahead of print]

Implication of phosphatidylethanolamine N-methyltransferase in adipocyte differentiation.
Presa N, Dominguez-Herrera A, van der Veen JN, Vance DE, Gómez-Muñoz A.
Biochim Biophys Acta Mol Basis Dis. 2020 Jun 2;1866(10):165853. doi: 10.1016/j.bbadis.2020.165853. [Epub ahead of print]

The effect of hydrophobic alkyl sidechains on size and solution behaviors of nanodiscs formed by alternating styrene maleamic copolymer.
Esmaili M, Acevedo-Morantes C, Wille HOverduin M.
Biochim Biophys Acta Biomembr. 2020 May 23;1862(10):183360. doi: 10.1016/j.bbamem.2020.183360. [Epub ahead of print]

Signalling by lysophosphatidate and its health implications.
Hemmings DG, Brindley DN.
Essays Biochem. 2020 May 26. pii: EBC20190088. doi: 10.1042/EBC20190088. [Epub ahead of print]

Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.
Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini GP, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaya V, Morgan J, Sorrell FJ, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers SP, Cheetham SC, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S.
J Med Chem. 2020 Jun 22. doi: 10.1021/acs.jmedchem.9b01803. [Epub ahead of print]

14-3-3 Proteins and Other Candidates form Protein-Protein Interactions with the Cytosolic C-terminal End of SOS1 Affecting Its Transport Activity.
Duscha K, Martins Rodrigues C, Müller M, Wartenberg R, Fliegel L, Deitmer JW, Jung M, Zimmermann R, Neuhaus HE.
Int J Mol Sci. 2020 May 8;21(9):E3334. doi: 10.3390/ijms21093334.PMID: 32397251 Free article.

Native nanodiscs formed by styrene-maleic acid copolymer derivatives help recover infectious prion multimers bound to brain-derived lipids.
Esmaili M, Tancowny BP, Wang X, Moses A, Cortez L, Sim V, Wille H, Overduin M.
J Biol Chem. 2020 May 1:jbc.RA119.012348. doi: 10.1074/jbc.RA119.012348. Online ahead of print.PMID: 32358064 Free article.

Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease.
Vanni I, Pirisinu L, Acevedo-Morantes C, Kamali-Jamil R, Rathod V, Di Bari MA, D'Agostino C, Marcon S, Esposito E, Riccardi G, Hornemann S, Senatore A, Aguzzi A, Agrimi U, Wille H, Nonno R.
Brain. 2020 May 1;143(5):1512-1524. doi: 10.1093/brain/awaa078.PMID: 32303068 Free PMC article.

PARL Protease: A Glimpse at Intramembrane Proteolysis in the Inner Mitochondrial Membrane.
Lysyk L, Brassard R, Touret N, Lemieux MJ.
J Mol Biol. 2020 Apr 19:S0022-2836(20)30283-7. doi: 10.1016/j.jmb.2020.04.006. Online ahead of print.PMID: 32320686 Review.

Dexamethasone Attenuates X-Ray-Induced Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle in Breast Tissue and Subsequent Breast Fibrosis.
Meng G, Wuest M, Tang X, Dufour J, McMullen TPW, Wuest F, Murray D, Brindley DN.
Cancers (Basel). 2020 Apr 18;12(4):999. doi: 10.3390/cancers12040999.PMID: 32325715 Free PMC article.

Role of the autotaxin-lysophosphatidate axis in the development of resistance to cancer therapy.
Tang X, Benesch MGK, Brindley DN.
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr 16;1865(8):158716. doi: 10.1016/j.bbalip.2020.158716. Online ahead of print.PMID: 32305571 Review.

Nucleotide Binding and Active Site Gate Dynamics for the Hsp90 Chaperone ATPase Domain from Benchtop and High Field 19F NMR Spectroscopy.
Rashid S, Lee BL, Wajda B, Spyracopoulos L.
J Phys Chem B. 2020 Apr 16;124(15):2984-2993. doi: 10.1021/acs.jpcb.0c00626. Epub 2020 Apr 3.PMID: 32212608

Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation.
Daude N, Kim C, Kang SG, Eskandari-Sedighi G, Haldiman T, Yang J, Fleck SC, Gomez-Cardona E, Han ZZ, Borrego-Ecija S, Wohlgemuth S, Julien O, Wille H, Molina-Porcel L, Gelpi E, Safar JG, Westaway D.
Acta Neuropathol. 2020 Mar 26. doi: 10.1007/s00401-020-02148-4. [Epub ahead of print]

Characterization of multimeric daptomycin bound to lipid nanodiscs formed by calcium-tolerant styrene-maleic acid copolymer.
Beriashvili D, Spencer NR, Dieckmann T, Overduin M, Palmer M.
Biochim Biophys Acta Biomembr. 2020 Mar 5;1862(6):183234. doi: 10.1016/j.bbamem.2020.183234. [Epub ahead of print]

Acidic residues of extracellular loop 3 of the Na+/H+ exchanger type 1 are important in cation transport.
Li X, Quan S, Corsiatto T, Fliegel L.
Mol Cell Biochem. 2020 Mar 4. doi: 10.1007/s11010-020-03707-9. [Epub ahead of print]