Recent Publications

View of the Endoplasmic Reticulum Through the Calreticulin Lens.
Agellon LB, Michalak M.
Prog Mol Subcell Biol. 2021;59:1-11. doi: 10.1007/978-3-030-67696-4_1.

Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress β-amyloid aggregation and neuronal toxicity.
Anand BG, Wu Q, Karthivashan G, Shejale KP, Amidian S, Wille H, Kar S.
Bioact Mater. 2021 May 10;6(12):4491-4505. doi: 10.1016/j.bioactmat.2021.04.029. eCollection 2021 Dec.

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.
Githaka JM, Tripathi N, Kirschenman R, Patel N, Pandya V, Kramer DA, Montpetit R, Zhu LF, Sonenberg N, Fahlman RP, Danial NN, Underhill DA, Goping IS.
Nat Commun. 2021 May 19;12(1):2939. doi: 10.1038/s41467-021-23269-8.

Physiological and pathological functions of sphingolipids in pregnancy.
Fakhr Y, Brindley DN, Hemmings DG.
Cell Signal. 2021 May 13;85:110041. doi: 10.1016/j.cellsig.2021.110041. Online ahead of print.

Ume6 acts as a stable platform to coordinate repression and activation of early meiosis-specific genes in Saccharomyces cerevisiae.
Raithatha SA, Vaza S, Islam MT, Greenwood B, Stuart DT.
Mol Cell Biol. 2021 May 3:MCB.00378-20. doi: 10.1128/MCB.00378-20. Online ahead of print.

The Emerging Role of Epigenetic Mechanisms in the Causation of Aberrant MMP Activity during Human Pathologies and the Use of Medicinal Drugs.
Sarker H, Haimour A, Toor R, Fernandez-Patron C.
Biomolecules. 2021 Apr 15;11(4):578. doi: 10.3390/biom11040578. Review.

Structural biology of endogenous membrane protein assemblies in native nanodiscs.
Brown CJ, Trieber C, Overduin M.
Curr Opin Struct Biol. 2021 Apr 26;69:70-77. doi: 10.1016/j.sbi.2021.03.008. Online ahead of print. Review.

N-Terminal finger stabilizes the S1 pocket for the reversible feline drug GC376 in the SARS-CoV-2 Mpro dimer.
Arutyunova E, Bashir Khan M, Fischer C, Lu J, Lamer T, Vuong W, van Belkum MJ, McKay RT, Lorne Tyrrell D, Vederas JC, Young HS, Joanne Lemieux
M.J Mol Biol. 2021 Apr 22:167003. doi: 10.1016/j.jmb.2021.167003. Online ahead of print.

Tauroursodeoxycholic acid/TGR5 signaling promotes survival and early development of glucose-stressed porcine embryos.
Dicks N, Gutierrez K, Currin L, de Macedo MP, Glanzner WG, Mondadori RG, Michalak M, Agellon LB, Bordignon V.
Biol Reprod. 2021 Apr 22:ioab072. doi: 10.1093/biolre/ioab072. Online ahead of print.

The Emerging Role of Epigenetic Mechanisms in the Causation of Aberrant MMP Activity during Human Pathologies and the Use of Medicinal Drugs.
Sarker H, Haimour A, Toor R, Fernandez-Patron C.
Biomolecules. 2021 Apr 15;11(4):578. doi: 10.3390/biom11040578. Review.

Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors.
Buckley BJ, Kumar A, Aboelela A, Bujaroski RS, Li X, Majed H, Fliegel L, Ranson M, Kelso MJ.
Int J Mol Sci. 2021 Mar 15;22(6):2999. doi: 10.3390/ijms22062999.PMID: 33804289

Aggregation of Aβ40/42 chains in the presence of cyclic neuropeptides investigated by molecular dynamics simulations.
Wu M, Dorosh L, Schmitt-Ulms G, Wille H, Stepanova M.
PLoS Comput Biol. 2021 Mar 12;17(3):e1008771. doi: 10.1371/journal.pcbi.1008771.

Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle.
Li MX, Mercier P, Hartman JJ, Sykes BD.
J Med Chem. 2021 Mar 25;64(6):3026-3034. doi: 10.1021/acs.jmedchem.0c01412. Epub 2021 Mar 11.

Targeting MMP-Regulation of Inflammation to Increase Metabolic Tolerance to COVID-19 Pathologies: A Hypothesis.
Hardy E, Fernandez-Patron C.
Biomolecules. 2021 Mar 6;11(3):390. doi: 10.3390/biom11030390.

FOXQ1 is Differentially Expressed Across Breast Cancer Subtypes with Low Expression Associated with Poor Overall Survival.
Elian FA, Are U, Ghosh S, Nuin P, Footz T, McMullen TPW, Brindley DN, Walter MA.
Breast Cancer (Dove Med Press). 2021 Mar 1;13:171-188. doi: 10.2147/BCTT.S282860. eCollection 2021.

Correction to: Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT‑P301L mutation.
Daude N, Kim C, Kang SG, Eskandari-Sedighi G, Haldiman T, Yang J, Fleck SC, Gomez-Cardona E, Han ZZ, Borrego-Ecija S, Wohlgemuth S, Julien O, Wille H, Molina-Porcel L, Gelpi E, Safar JG, Westaway D.
Acta Neuropathol. 2021 Mar;141(3):467-468. doi: 10.1007/s00401-021-02262-x.