Recent Publications

Nothing Regular about the Regulins: Distinct Functional Properties of SERCA Transmembrane Peptide Regulatory Subunits.
Rathod N, Bak JJ, Primeau JO, Fisher ME, Espinoza-Fonseca LM, Lemieux MJ, Young HS.
Int J Mol Sci. 2021 Aug 18;22(16):8891. doi: 10.3390/ijms22168891.

Biosynthesis of Silver Nanoparticles Using Stenocereus queretaroensis Fruit Peel Extract: Study of Antimicrobial Activity.
Padilla-Camberos E, Sanchez-Hernandez IM, Torres-Gonzalez OR, Ramirez-Rodriguez P, Diaz E, Wille H, Flores-Fernandez JM.
Materials (Basel). 2021 Aug 12;14(16):4543. doi: 10.3390/ma14164543

Lysophosphatidate Promotes Sphingosine 1-Phosphate Metabolism and Signaling: Implications for Breast Cancer and Doxorubicin Resistance.
Venkatraman G, Tang X, Du G, Parisentti AM, Hemmings DG, Brindley DN.
Cell Biochem Biophys. 2021 Aug 20. doi: 10.1007/s12013-021-01024-6. Online ahead of print.

Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion.
Cai R, Wang L, Liu X, Michalak M, Tang J, Peng JB, Chen XZ.
Commun Biol. 2021 Aug 19;4(1):990. doi: 10.1038/s42003-021-02521-3.

Calcium signaling and endoplasmic reticulum stress.
Groenendyk J, Agellon LB, Michalak M.
Int Rev Cell Mol Biol. 2021;363:1-20. doi: 10.1016/bs.ircmb.2021.03.003. Epub 2021 May 19.

Phosphoinositide Recognition Sites Are Blocked by Metabolite Attachment.
Kervin TA, Wiseman BC, Overduin M.
Front Cell Dev Biol. 2021 Jul 22;9:690461. doi: 10.3389/fcell.2021.690461. eCollection 2021.

Mapping human calreticulin regions important for structural stability.
Čiplys E, Paškevičius T, Žitkus E, Bielskis J, Ražanskas R, Šneideris T, Smirnovas V, Kaupinis A, Tester DJ, Ackerman MJ, Højrup P, Michalak M, Houen G, Slibinskas R.
Biochim Biophys Acta Proteins Proteom. 2021 Nov;1869(11):140710. doi: 10.1016/j.bbapap.2021.140710. Epub 2021 Aug 4.

The phosphoinositide code is read by a plethora of protein domains.
Overduin M, Kervin TA.
Expert Rev Proteomics. 2021 Aug 23:1-20. doi: 10.1080/14789450.2021.1962302. Online ahead of print.

Photocleavable proteins that undergo fast and efficient dissociation.
Lu X, Wen Y, Zhang S, Zhang W, Chen Y, Shen Y, Lemieux MJ, Campbell RE.
Chem Sci. 2021 May 31;12(28):9658-9672. doi: 10.1039/d1sc01059j. eCollection 2021 Jul 21.

Positron Emission Tomography Imaging of Autotaxin in Thyroid and Breast Cancer Models Using [18F]PRIMATX.
Litchfield M, Wuest M, Glubrecht D, Briard E, Auberson YP, McMullen TPW, Brindley DN, Wuest F.
Mol Pharm. 2021 Jul 28. doi: 10.1021/acs.molpharmaceut.1c00265. Online ahead of print.

New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene.
Hannaoui S, Triscott E, Duque Velásquez C, Chang SC, Arifin MI, Zemlyankina I, Tang X, Bollinger T, Wille H, McKenzie D, Gilch S.
PLoS Pathog. 2021 Jul 26;17(7):e1009795. doi: 10.1371/journal.ppat.1009795. Online ahead of print.

Stimulation of Ca2+-ATPase transport activity by a small-molecule drug.
Sordi G, Goti A, Young HS, Palchetti I, Tadini-Buoninsegni F.
ChemMedChem. 2021 Jul 23. doi: 10.1002/cmdc.202100350. Online ahead of print.

The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.
Sanderson MR, Fahlman RP, Wevrick R.
J Biol Chem. 2021 Jul 12:100959. doi: 10.1016/j.jbc.2021.100959. Online ahead of print.

Viswanathan Natarajan: A Giant in Lipid Research and Pulmonary Disease and a True Gentleman.
Brindley DN.
Cell Biochem Biophys. 2021 Jul 12:1-4. doi: 10.1007/s12013-021-01018-4. Online ahead of print.

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability.
Bai B, Belovodskiy A, Hena M, Kandadai AS, Joyce MA, Saffran HA, Shields JA, Khan MB, Arutyunova E, Lu J, Bajwa SK, Hockman D, Fischer C, Lamer T, Vuong W, van Belkum MJ, Gu Z, Lin F, Du Y, Xu J, Rahim M, Young HS, Vederas JC, Tyrrell DL, Lemieux MJ, Nieman JA.
J Med Chem. 2021 Jul 9:acs.jmedchem.1c00616. doi: 10.1021/acs.jmedchem.1c00616. Online ahead of print.

Treatment and prevention strategies for the COVID 19 pandemic: A review of immunotherapeutic approaches for neutralizing SARS-CoV-2.
Baral PK, Yin J, James MNG.
Int J Biol Macromol. 2021 Jul 5;186:490-500. doi: 10.1016/j.ijbiomac.2021.07.013. Online ahead of print.

Deciphering Network Crosstalk: The Current Status and Potential of miRNA Regulatory Networks on the HSP40 Molecular Chaperone Network.
Budrass L, Fahlman RPMok SA.
Front Genet. 2021 Jun 21;12:689922. doi: 10.3389/fgene.2021.689922. eCollection 2021.

Structures and Dynamics of Native-State Transmembrane Protein Targets and Bound Lipids.
Overduin M, Trieber C, Prosser RS, Picard LP, Sheff JG.
Membranes (Basel). 2021 Jun 17;11(6):451. doi: 10.3390/membranes11060451.

Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm.
Cortez LM, Nemani SK, Duque Velásquez C, Sriraman A, Wang Y, Wille H, McKenzie D, Sim VL.
PLoS Pathog. 2021 Jun 28;17(6):e1009703. doi: 10.1371/journal.ppat.1009703. eCollection 2021 Jun.

Large conformational dynamics in Band 3 protein: Significance for erythrocyte senescence signalling.
Badior KE, Casey JR.
Biochim Biophys Acta Biomembr. 2021 Oct 1;1863(10):183678. doi: 10.1016/j.bbamem.2021.183678. Epub 2021 Jun 24.

Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies.
Vuong W, Fischer C, Khan MB, van Belkum MJ, Lamer T, Willoughby KD, Lu J, Arutyunova E, Joyce MA, Saffran HA, Shields JA, Young HS, Nieman JA, Tyrrell DL, Lemieux MJ, Vederas JC.
Eur J Med Chem. 2021 May 30;222:113584. doi: 10.1016/j.ejmech.2021.113584. Online ahead of print.

Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA.
Fisher ME, Bovo E, Aguayo-Ortiz R, Cho EE, Pribadi MP, Dalton MP, Rathod N, Lemieux MJ, Espinoza-Fonseca LM, Robia SL, Zima AV, Young HS.
Elife. 2021 Jun 2;10:e65545. doi: 10.7554/eLife.65545.

Regulation of the Phosphoinositide Code by Phosphorylation of Membrane Readers.
Kervin TA, Overduin M.
Cells. 2021 May 14;10(5):1205. doi: 10.3390/cells10051205.

The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models.
Kamali-Jamil R, Vázquez-Fernández E, Tancowny B, Rathod V, Amidian S, Wang X, Tang X, Fang A, Senatore A, Hornemann S, Dudas S, Aguzzi A, Young HSWille H.
PLoS Pathog. 2021 Jun 1;17(6):e1009628. doi: 10.1371/journal.ppat.1009628. eCollection 2021 Jun.

View of the Endoplasmic Reticulum Through the Calreticulin Lens.
Agellon LB, Michalak M.
Prog Mol Subcell Biol. 2021;59:1-11. doi: 10.1007/978-3-030-67696-4_1.