BME Seminar Series on Nov. 28

    Title: Targeting the Senescence-Associated Secretory Phenotype: The profound effects of natural molecules on inflammation produced by senescent cells
    Location: RTF 1-075
    Time: Noon to 1:00PM

    November 21, 2018

    Presenter: Kevin Perrott

    Abstract:

    Natural compounds from fruits and vegetables such apigenin (4',5,7,-trihydroxyflavone) have been shown to have pleotropic effects able to attenuate the inflammation associated with many chronic diseases of aging. Senescent cells-stressed cells that accumulate with age in mammals-display a pro-inflammatory senescence-associated secretory phenotype (SASP) that can drive or exacerbate several age-related pathologies, including cancer. This work examines the effects and mechanisms of apigenin and other natural compounds on senescence and the SASP looking at the role these natural compounds could play in reducing tumorigenesis.