Department of Critical Care

Recent Publications

Academic Faculty Publications

  • Constantine Karvellas
    Cardoso FS, Bagshaw SM, Abraldes JG, Kneteman NM, Meeberg G, Fidalgo P,Karvellas CJ. Comorbidities have a limited impact on post-transplant survival in carefully selected cirrhotic patients: a population-based cohort study. Ann Hepatol. 2015 Jul-Aug;14(4):505-14. PubMed PMID: 26019037.
    Cardoso FS, Karvellas CJ, Kneteman NM, Meeberg G, Fidalgo P, Bagshaw SM. Postoperative resource utilization and survival among liver transplant recipients with Model for End-stage Liver Disease score ≥ 40: A retrospective cohort study. Can J Gastroenterol Hepatol. 2015 May;29(4):185-91. PubMed PMID: 25965438; PubMed Central PMCID: PMC4444027.
    Karvellas CJ, Abraldes JA, Arabi Y, Kumar A. Appropriate and timely antimicrobial therapy in cirrhotic patients with spontaneous bacterial peritonitis-associated septic shock: a retrospective cohort study. Aliment Pharmacol Ther. 2015 Apr;41(8):747-57. IF 5.5.
    Speiser, J, Lee, WM, Karvellas CJ. Predicting outcome on admission and post-admission for acetaminophen-induced acute liver failure using classification and regression tree models. PloS One. 2015 Apr 17;10(4):e0122929. IF 3.5.
    Cardoso FS, Karvellas CJ, Kneteman NM, Meeberg G, Fidalgo P, Bagshaw SM. Postoperative Resource Utilization and Survival among Liver Transplant Recipients with MELD greater or equal to 40: A Retrospective Cohort Study. Can J Gastroenterol Hepatol. 2015 May;29(4):185-91. IF 2.0.
    Kaur G, Leslie EM, Tillman H, Lee WM, Swanlund DP, Karvellas CJ. Detection of Ophthalmic Acid in Serum from Acetaminophen-induced Acute Liver Failure Patients is More Frequent in Non-survivors. PLoS One. 2015 Sep 25;10(9):e0139299. IF 3.5.
    Nadim MK, Durand F, Kellum JA, Levitsky J, O'Leary JG, Karvellas CJ, Bajaj JS, Davenport A, Jalan R, Angeli P, Caldwell SH, Fernández J, Francoz C, Garcia-Tsao G, Ginès P, Ison MG, Kramer DJ, Mehta RL, Moreau R, Mulligan D, Olson JC, Pomfret EA, Senzolo M, Steadman RH, Subramanian RM, Vincent JL, Genyk YS. Management of the Critically Ill Patient with Cirrhosis: A Multidisciplinary Perspective. Journal of Hepatology. 2015 (Epub October 28th).
    Karvellas CJ, Stravitz RT. High Volume Plasma Exchange in Acute Liver Failure: Dampening the inflammatory cascade? Journal of Hepatology 2015. (in press) IF 11.3.
    Pai R, Karvellas CJ. Is Palliative Care Appropriate in the Liver Transplant Candidate? Clin Liver Dis. 2015 Vol 6(1):24–26.
    Karvellas CJ, Durand F, Nadim MN. Acute kidney injury in Cirrhosis. Crit Care Clin. 2015. 2015 Oct;31(4):737-50. IF 2.5.
    Karvellas CJ, Subramanian R.Current Evidence for Extracorporeal Liver Support Systems in Acute and Acute on Chronic Liver Failure. Crit Care Clin 2015. (in press) IF 2.5.
    Kupper S, Karvellas C, Khadaroo R, Widder S, Acute Care and Emergency Surgery (ACES) Group. Increased Health Services Use by Severely Obese Patients Undergoing Emergency Surgery: A Retrospective Cohort Study. Can J Surg. 2015 Feb;58(1):41-47.

    Peer-Reviewed

    Poonja Z, Brisebois A, Veldhuyzen van Zanten S, Tandon P, Meeberg G, Karvellas C. Patients with Cirrhosis and Denied Liver Transplants Rarely Receive Adequate Palliative Care or Appropriate Management. Clin Gastroenterol Hepatol. 2014 Apr; 12(4): 692-8.
    Karvellas CJ, Fix OK, Battenhouse H, Durkalski V, Sanders C, Lee WM; for the U.S. Acute Liver Failure Study Group. Outcomes and Complications of Intracranial Pressure Monitoring in Acute Liver Failure: A Retrospective Cohort Study. Crit Care Med. 2014 May; 42(5): 1157-1167.
    Karvellas CJ, Cavazos J, Battenhouse H, Durkalski V, Balko J, Sanders C, Lee WM; US Acute Liver Failure Study Group. Effects of Antimicrobial Prophylaxis and Blood Stream Infections in Patients with Acute Liver Failure: a Retrospective Cohort Study. Clin Gastroenterol Hepatol. 2014 Nov;12(11):1942-9.
    Cardoso FS, Karvellas CJ, Kneteman NM, Meeberg G, Fidalgo P, Bagshaw SM. Respiratory rate at ICU discharge after liver transplant is an independent risk factor for ICU readmission within the same hospital stay: a nested case-control study. J Crit Care. 2014 Oct;29(5):791-6.
    Du Y, Karvellas CJ, Baracos VE, Williams DC and Khadaroo R. Sarcopenia is a Predictor of Outcomes in Very Elderly Patients Undergoing Emergency Surgery. Surgery. 2014 Sep;156(3):521-7.
    Karvellas CJ, Stravitz RT, Battenhouse H, Lee WM, Schilsky ML; for the US Acute Liver Failure Study Group. Therapeutic hypothermia in acute liver failure: A multi-center retrospective cohort analysis. Liver Transpl. 2015 Jan; 21(1):4-12.
    Kupper S, Karvellas CJ, Khadaroo R, Widder SQ. Increased health services use by severely obese patients undergoing emergency surgery: a retrospective cohort study. Can J Surg. 2015 Feb; 58(1):41-7.
    Karvellas CJ, Abraldes JA, Arabi Y, Kumar A. Appropriate and timely antimicrobial therapy in cirrhotic patients with spontaneous bacterial peritonitis-associated septic shock: a retrospective cohort study. Aliment Pharmacol Ther. 2015 Apr;41(8):747-57.
    Speiser, J, Lee, WM, Karvellas CJ. Predicting outcome on admission and post-admission for acetaminophen-induced acute liver failure using classification and regression tree models. PloS One. 2015 Apr 17;10(4):e0122929.
    Cardoso FS, Karvellas CJ, Kneteman NM, Meeberg G, Fidalgo P, Bagshaw SM. Postoperative Resource Utilization and Survival among Liver Transplant Recipients with MELD greater or equal to 40: A Retrospective Cohort Study. Can J Gastroenterol Hepatol. 2015 May;29(4):185-91.
    Cardoso FS, Bagshaw SM, Abraldes JG, Kneteman NM, Meeberg G, Fidalgo P, Bagshaw SM, Karvellas CJ. Comorbidities have a limited impact on post-transplant survival in carefully selected cirrhotic patients: a population-based cohort study. Ann Hepatol. 2015;14(4):505-514.
    Kaur G, Leslie EM, Tillman H, Lee WM, Swanlund DP, Karvellas CJ. Detection of Ophthalmic Acid in Serum from Acetaminophen-induced Acute Liver Failure Patients is More Frequent in Non-survivors. PLoS One. 2015 Sep 25;10(9):e0139299.
    Nadim MK, Durand F, Kellum JA, Levitsky J, O'Leary JG, Karvellas CJ, Bajaj JS, Davenport A, Jalan R, Angeli P, Caldwell SH, Fernández J, Francoz C, Garcia-Tsao G, Ginès P, Ison MG, Kramer DJ, Mehta RL, Moreau R, Mulligan D, Olson JC, Pomfret EA, Senzolo M, Steadman RH, Subramanian RM, Vincent JL, Genyk YS. Management of the Critically Ill Patient with Cirrhosis: A Multidisciplinary Perspective. Journal of Hepatology. J Hepatol. 2016 Mar; 64(3):717-35.
    Karvellas CJ, Tillman H, Leung AA, Lee WM, Schilsky ML, Hameed B, Todd Stravitz R, McGuire BM, Fix OK; United States Acute Liver Failure Study Group. Acute Liver Injury and Acute Liver Failure from Mushroom Poisoning in North America. Liver Int. 2016 Feb 2{Epub ahead of print].
    Reuben A, Tillman H, Fontana R, Davern T, Mcguire B, Stravitz RT, Durkalski V, Larson A, Liou I, Fix OK, Schilsky ML, McCashland T, Hay E, Murray N, Shaikh O, Ganger D, Zaman A, Han SH, Chung R, Smith A, Brown RS, Crippin J, Harrison J, Koch DG, Munoz S, Reddy R, Rossaro L, Satyanarayana R, Hassenein T, Hanje AJ, Olson J, Subramanian R, Karvellas CJ, Hameed B, Sherker A, Robuck P, Lee WM. OUTCOMES IN ADULTS WITH ACUTE LIVER FAILURE (ALF) FROM 1998 TO 2013: AN OBSERVATIONAL COHORT STUDY. Ann Intern Med 2016 (in press).

    Peer-Reviewed: Invited Reviews

    Karvellas CJ, Bagshaw SM. Advances in management and prognostication in critically ill cirrhotic patients. Curr Opin Crit Care. 2014 Apr; 20(2): 210-7.
    Pai R, Karvellas CJ. Is Palliative Care Appropriate in the Liver Transplant Candidate? Clin Liver Dis. 2015 Vol 6(1):24–26.

    Karvellas CJ, Durand F, Nadim MN. Acute kidney injury in Cirrhosis. Crit Care Clin. 2015. 2015 Oct;31(4):737-50.

    Karvellas CJ, Subramanian R.Current Evidence for Extracorporeal Liver Support Systems in Acute and Acute on Chronic Liver Failure. Crit Care Clin 2016. (in press)
  • David Zygun

    Peer-Reviewed: Invited Reviews

    Mauricio Ferri, David A Zygun, Alexandra Harrison and Henry T Stelfox “ Evidence-based design in an intensive care unit: End-user perceptions”. Journal: BMC Anesthesiology MS : 1082726862148637; Peer reviewed. Abstract
    Azevedo LC, de Souza IA, Zygun DA, Stelfox HT, Bagshaw SM. Association Between Nighttime Discharge from the Intensive Care Unit and Hospital Mortality: A Multi-Center Retrospective Cohort Study. BMC Health Serv Res. 2015 Sep 14;15:378. doi: 10.1186/s12913-015-1044-4. PubMed PMID: 26369933; PubMed Central PMCID: PMC4570509. >

    Abstract

    Stelfox T, Niven D, Bagshaw S, McKenzie E, Potestio M, Clement F, Zygun D, on behalf of the Critical Care Strategic Clinical Network (CCSCN), *University of Calgary, University of Alberta, Alberta Health Services “Stakeholder engagement to identify priorities for improving the quality and value of care provided to critically ill patients” presented Abstract at 35th International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium March, 2015.
  • Jim Kutsogiannis
    Heyland DK, Garland A, Bagshaw SM, Cook D, Rockwood K, Stelfox HT, Dodek P, Fowler RA, Turgeon AF, Burns K, Muscedere J, Kutsogiannis J, Albert M, Mehta S, Jiang X, Day AG. Recovery after critical illness in patients aged 80 years or older: a multi-center prospective observational cohort study. Intensive Care Med. 2015 Nov;41(11):1911-20. doi: 10.1007/s00134-015-4028-2. Epub 2015 Aug 26. PubMed PMID: 26306719.
    Heyland D, Cook D, Bagshaw SM, Garland A, Stelfox HT, Mehta S, Dodek P, Kutsogiannis J, Burns K, Muscedere J, Turgeon AF, Fowler R, Jiang X, Day AG; Canadian Critical Care Trials Group; Canadian Researchers at the End of Life Network. The Very Elderly Admitted to ICU: A Quality Finish? Crit Care Med. 2015 Jul;43(7):1352-60. doi: 10.1097/CCM.0000000000001024. PubMed PMID: 25901550.
    Heyland DK, Dodek P, Mehta S, Cook D, Garland A, Stelfox HT, Bagshaw SM, Kutsogiannis DJ, Burns K, Muscedere J, Turgeon AF, Fowler R, Jiang X, Day AG; Canadian Critical Care Trials Group and Canadian Researchers at End of Life Network (CARENET). Admission of the very elderly to the intensive care unit: family members' perspectives on clinical decision-making from a multicenter cohort study. Palliat Med. 2015 Apr;29(4):324-35. doi: 10.1177/0269216314566060. Epub 2015 Feb 2. PubMed PMID: 25645668.

    Peer-Reviewed

    Heyland D, Stelfox H, Garland A, Cook D, Dodek P, Kutsogiannis D, Jiang X, Day A.; Predicting Performances Status One Year After Critical Illness Among Patients Aged 80 Years or older. Crit Care Med. 2015 Dec;43(12 Suppl 1):14.
    Digby GC, Keenan SP, Parker CM, Sinuff T, Burns KE, Mehta S, Ronco JJ, Kutsogiannis DJ, Rose L, Ayas NT, Berthiaume LR, D'Arsigny CL, Stollery DE, Muscedere J.;Noninvasive ventilation practice patterns for acute respiratory failure in Canadian tertiary care centres: A descriptive analysis. Can Respir J. 2015 Oct 15. pii: 17038.
    Heyland D, Cook D, Bagshaw SM, Garland A, Stelfox HT, Mehta S, Dodek P, Kutsogiannis J, Burns K, Muscedere J,Turgeon AF, Fowler R, Jiang X, Day AG; Very Elderly Admitted to Intensive Care Unit: A quality finish? Canadian Critical Care Trials Group and the Canadian Researchers at the End of Life Network. Crit Care Med. 2015 Jul:43(7) 135-60.
    Heyland DK, Garland A, Bagshaw SM, Cook D, Rockwood K, Stelfox HT, Dodek P, Fowler RA, Turgeon AF, Burns K, Muscedere J, Kutsogiannis J, Albert M, Mehta S, Jiang X, Day AG. Recovery after critical illness in patients aged 80 years or older: a multi-center prospective observational cohort study. Intensive Care Med. 2015 Nov;41(11):1911-20. doi: 10.1007/s00134-015-4028-2. Epub 2015 Aug 26.
    Heyland D, Dodek P, Mehta S, Cook D, Garland A, Stelfox H, Bagshaw S, Kutsogiannis DJ, Burns K, Muscedere J, Turgeon A, Fowler R, Jiang X, Day A, on behalf of the Canadian Critical Care Trials Group and the Canadian Researchers at the End of Life Network (CARENET). Admission of the very elderly to the intensive care unit: Family members’ perspectives on clinical decision-making from a multicenter cohort study. Palliative Medicine 2015 Apr; 29(4):324-35.
    Mehta S, Cook D, Devlin JW, Skrobik Y, Meade M, Fergusson D, Herridge M, Steinberg M, Granton J, Ferguson N, Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Mallick R, Reynolds S, Keenan S, Burry L; SLEAP Investigators; Canadian Critical Care Trials Group. Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults. Critical Care Med March 2015; 43(3):557-66.
    Skoufi U., Arvanitis D., Lampri L., Loachim E,Kutsogiannis DJ., Skoufi D.,Tsironis D., Mitselou A. Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma. J Interdiscipl Histopathol 2014; 2(3): 135-14.
    Dhanani S, Hornby L, Ward R, Baker A, Dodek P, Chamber-Evans J, Fowler R, Friedrich JO, Gow RM, Kutsogiannis DJ,Mcintyre L, Momoli F, Morin K, Ramsay T,Scales D,Write H, Yildirim S, Young B, Shemie, S. Vital Signs after Cardiac Arrest Following Withdrawal of Life-Sustaining Therapy: A Multicenter Prospective Observational Study. Critical Care Medicine 2014 Nov:42(11) 2358-69.

    Collaborator

    Heyland DK, Elke G, Cook D, Berger MM, Wischmeyer PE, Albert M, Muscedere J, Jones G, Day AG; Canadian Critical Care Trials Group. Glutamine and antioxidants in the critically ill patient: a post hoc analysis of a large-scale randomized trial. JPEN J Parenter Enteral Nutr. 2015 May;39(4):401-9.
    The CST/CNTRP increased risk donor working group. Guidance on the Use of Increased Infectious Risk
    Donors for Organ Transplantation. Transplant Journal. 2014 Aug:98(4):365-9.
    Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, Elke G, Berger MM, Day AG, Canadian Critical Care Trials Group. A randomized trial of Glutamine and antioxidants in Critically Ill Patients. N Eng J Med 2013 Apr;368(16): 1489-1497.
    Cohen AT, Spiro TE, Büller HR, Haskell L, Hu D, Hull R, Mebazaa A, Merli G, Schellong S, Spyropoulos AC, Tapson V; MAGELLAN Investigators. Rivaroxaban for Thromboprophylaxis in Acutely Ill Medical Patients. N Engl J Med. 2013 Feb 7; 368 (6):513-23. doi: 10.1056/NEJMoa1111096.

    Editorials/Commentaries

    Shemie S, MacDonald S, on behalf of the Canadian Blood Services: Ethics Guide for Donation Physicians, Recommendations developed through a national collaboration among Canadian deceased donation experts and bioethicists, and endorsed by the Canadian Medical Association. November 2015 Ahead of Publication.
    Shemie S, MacDonald S, on behalf of  Canadian Blood Services — Canadian Critical Care Society Expert Consultation Group Improving the process of deceased organ and tissue donation: a role for donation physicians as specialists CMAJ. 2014 Feb 4; 186(2): 95–96.

    Published Abstracts/Poster Presentations

    NOTE: **denotes international meeting | *denotes national meeting

    Doucette K, Worton K, Kutsogiannis DJ and Preiksaitis J. Utilization of Increased Risk Donors in a Canadian Multi-Organ Transplant Program. Joint Conference with American Society of Transplant Surgeons and American Society of Transplantation, Philadelphia (USA), May 2015. **
    Le Roux P, Suarez J. PRINCE: Point Prevalence Study In Neurocritical Care. Point Prevalance Cross Sectional Observational, Non-Interventional Study. Annual Neurocritical Care Conference in Seattle, WA (USA), September 2014. **
    Zytaruk Z, Duffett M, Lauzier F,Ye C, Dodek PM, Paunovic B, Fowler R, Kho ME, Foster D,Stelfox T, Sinuff T, Clarke F, Wood G,Cox M, Kutsiogiannis DJ, Jacka M,Roussos M, Kumar K, Guyatt G and Cook DJ, for the CONECCKT-T. Investigators and the Canadian Critical Care Trials Group. Barriers and Facilitators of Thromboprophylaxis for Medical-Surgical ICU Patients: A Multicenter Survey . Am J Resp Crit Care Med 2014 (Abstract).
    Centofanti J, Zytaruk N, Foster D, Martinka G, Hand L, Karachi T, Mehta S, Granton J, Muscedere J, O’Callaghan N, Dodek P, Ashley BJ, McIntyre LL, Watpool I,Kutsiogiannis DJ, Jacka M, Fowler R, Wood G, Auld F, Cook DJ for the CONECCKTT Investigators and the CCCTG. Pre-printed Orders for Thromboprophylaxis in the ICU: A Cross-Sectional Analysis. American Thoracic Society Meeting, San Diego, California, May 16-21, 2014.**
  • Michael Jacka
    McAlister FA, Jacka M, Graham M, Youngson E, Cembrowski G, Bagshaw SM, Pannu N, Townsend DR, Srinathan S, Alonso-Coello P, Devereaux PJ. The prediction of postoperative stroke or death in patients with preoperative atrial fibrillation undergoing non-cardiac surgery: a VISION sub-study. J Thromb Haemost. 2015 Oct;13(10):1768-75. doi: 10.1111/jth.13110. Epub 2015 Sep 14. PubMed PMID:26270168.
    van Diepen S, Granger CB, Jacka M, Gilchrist IC Morrow DA, Katz JN. The Unmet Need for Addressing Cardiac Issues in Intensive Care Research. Critical Care Medicine 2015; 43(1):128-134.
    Burry L; Cook D; Herridge M; Devlin JW; Fergusson D; Meade M; Steinberg M; Skrobik Y; Olafson K; Burns K; Dodek P; Granton J; Ferguson N; Jacka M; Tanios M; Fowler R; Reynolds S; Keenan S; Mallick R; Mehta S; SLEAP Investigators and the Canadian Critical Care Trials Group. Recall of ICU Stay in Patients Managed With a Sedation Protocol or a Sedation Protocol With Daily Interruption. Critical Care Medicine. 43(10):2180-90, 2015 Oct.
    Jacka, Michael; Nahirniak, Susan. ACP Journal Club. In critically ill adults, transfusion of fresh vs standard-issue red blood cells did not differ for 90-day mortality. Annals of Internal Medicine. 163(2):JC5, 2015 Jul 21.
    Mehta S; Cook D; Devlin JW; Skrobik Y; Meade M; Fergusson D; Herridge M; Steinberg M; Granton J; Ferguson N; Tanios M; Dodek P; Fowler R; Burns K; Jacka M; Olafson K; Mallick R; Reynolds S; Keenan S; Burry L; SLEAP Investigators; Canadian Critical Care Trials Group. Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults. Critical Care Medicine. 43(3):557-66, 2015 Mar. [Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, Non-U.S. Gov't] UI: 25493968.
    van Diepen S; Granger CB; Jacka M; Gilchrist IC; Morrow DA; Katz JN. Critical Care Medicine. 43(1):128-34, 2015 Jan.
    Lim W; Meade M; Lauzier F; Zarychanski R; Mehta S; Lamontagne F; Dodek P; McIntyre L; Hall R; Heels-Ansdell D; Fowler R; Pai M; Guyatt G; Crowther MA; Warkentin TE; Devereaux PJ; Walter SD; Muscedere J; Herridge M; Turgeon AF; Geerts W; Finfer S; Jacka M; Berwanger O; Ostermann M; Qushmaq I; Friedrich JO; Cook DJ; PROphylaxis for ThromboEmbolism in Critical Care Trial Investigators. Failure of anticoagulant thromboprophylaxis: risk factors in medical- surgical critically ill patients*. Critical Care Medicine. 43(2):401-10, 2015 Feb. [Journal Article. Multicenter Study. Randomized Controlled Trial. Research Support, Non-U.S. Gov't] UI: 25474533.
    Canadian Guidelines for the use of targeted temperature management (therapeutic hypothermia) after cardiac arrest: A joint statement from The Canadian Critical Care Society (CCCS), Canadian Neurocritical Care Society (CNCCS), and the Canadian Critical Care Trials Group (CCCTG). Howes D, Gray SH, Brooks SC, Boyd JG, Djogovic D, Golan E, Green RS, Jacka MJ, Sinuff T, Chaplin T, Smith OM, Owen J, Szulewski A, Murphy L, Irvine S, Jichici D, Muscedere J. Resuscitation. 2016 Jan;98:48-63. doi: 10.1016/j.resuscitation.2015.07.052. Epub 2015 Sep 28. PMID: 26417702.
  • Sean Bagshaw
    Bagshaw SM, Darmon M, Ostermann M, Finkelstein FO, Wald R, Tolwani AJ, Goldstein SL, Gattas DJ, Uchino S, Hoste EA, Gaudry S. Current state of the art for renal replacement therapy in critically ill patients with acute kidney injury. Intensive Care Med. 2017 Mar 13. doi: 10.1007/s00134-017-4762-8. [Epub ahead of print]. PMID: 28289816.
    Bagshaw SM, Wald R.Strategies for the optimal timing to start renal replacement therapy in critically ill patients with acute kidney injury. Kidney Int. 2017 May;91(5):1022-1032. doi: 10.1016/j.kint.2016.09.053. PMID: 28222898.
    Wald R, Gallagher M, Bagshaw SM. Shedding New Light on an Old Dilemma: Two Trials Examining the Timing of Renal Replacement Therapy Initiation in Acute Kidney Injury. Am J Kidney Dis. 2017 Jan;69(1):14-17. doi: 10.1053/j.ajkd.2016.09.009. PMID: 27836447.
    MacIntyre E, Asadi L, Mckim DA, Bagshaw SM. Clinical outcomes associated with home mechanical ventilation: A systematic review. Can Respir J. 2015 Sep 30. pii:17132. [Epub ahead of print] PubMed PMID: 26422402.
    Rewa O, Wald R, Adhikari NK, Hladunewich M, Lapinsky S, Muscedere J, Bagshaw SM, Smith OM, Lebovic G, Kuint R, Klein DJ. Whole-blood neutrophil gelatinase-associated lipocalin to predict adverse events in acute kidney injury: A prospective observational cohort study. J Crit Care. 2015 Sep 1. pii:S0883-9441(15)00454-2. doi: 10.1016/j.jcrc.2015.08.019. [Epub ahead of print] PubMed PMID: 26421697.
    Rewa O, Bagshaw SM. Principles of Fluid Management. Crit Care Clin. 2015 Oct;31(4):785-801. doi: 10.1016/j.ccc.2015.06.012. Epub 2015 Aug 8. Review. PubMed PMID: 26410145.
    Azevedo LC, de Souza IA, Zygun DA, Stelfox HT, Bagshaw SM. Association Between Nighttime Discharge from the Intensive Care Unit and Hospital Mortality: A Multi-Center Retrospective Cohort Study. BMC Health Serv Res. 2015 Sep 14;15:378. doi: 10.1186/s12913-015-1044-4. PubMed PMID: 26369933; PubMed Central PMCID: PMC4570509.
    Heyland DK, Garland A, Bagshaw SM, Cook D, Rockwood K, Stelfox HT, Dodek P, Fowler RA, Turgeon AF, Burns K, Muscedere J, Kutsogiannis J, Albert M, Mehta S, Jiang X, Day AG. Recovery after critical illness in patients aged 80 years or older: a multi-center prospective observational cohort study. Intensive Care Med. 2015 Nov;41(11):1911-20. doi: 10.1007/s00134-015-4028-2. Epub 2015 Aug 26. PubMed PMID: 26306719.
    Jacobs R, Honoré PM, Bagshaw SM, Diltoer M, Spapen HD. Citrate Formulation Determines Filter Lifespan during Continuous Veno-Venous Hemofiltration: A Prospective Cohort Study. Blood Purif. 2015;40(3):194-202. doi: 10.1159/000438820. Epub 2015 Aug 22. PubMed PMID: 26302765.
    McAlister FA, Jacka M, Graham M, Youngson E, Cembrowski G, Bagshaw SM, Pannu N, Townsend DR, Srinathan S, Alonso-Coello P, Devereaux PJ. The prediction of postoperative stroke or death in patients with preoperative atrial fibrillation undergoing non-cardiac surgery: a VISION sub-study. J Thromb Haemost. 2015 Oct;13(10):1768-75. doi: 10.1111/jth.13110. Epub 2015 Sep 14. PubMed PMID:26270168.
    Rewa O, Villeneuve PM, Eurich DT, Stelfox HT, Gibney RT, Hartling L, Featherstone R, Bagshaw SM. Quality indicators in continuous renal replacement therapy (CRRT) care in critically ill patients: protocol for a systematic review. Syst Rev. 2015 Jul 30;4:102. doi: 10.1186/s13643-015-0088-1. PubMed PMID: 26224139; PubMed Central PMCID: PMC4520065.
    Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, Edipidis K, Forni LG, Gomersall CD, Govil D, Honoré PM, Joannes-Boyau O, Joannidis M, Korhonen AM, Lavrentieva A, Mehta RL, Palevsky P, Roessler E, Ronco C, Uchino S, Vazquez JA, Vidal Andrade E, Webb S, Kellum JA. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med. 2015 Aug;41(8):1411-23. doi: 10.1007/s00134-015-3934-7. Epub 2015 Jul 11. PubMed PMID: 26162677.
    Buchner DL, Bagshaw SM, Dodek P, Forster AJ, Fowler RA, Lamontagne F, Turgeon AF, Potestio M, Stelfox HT. Prospective cohort study protocol to describe the transfer of patients from intensive care units to hospital wards. BMJ Open. 2015 Jul 8;5(7):e007913. doi: 10.1136/bmjopen-2015-007913. PubMed PMID: 26155820; PubMed Central PMCID: PMC4499701.
    Wald R, Adhikari NK, Smith OM, Weir MA, Pope K, Cohen A, Thorpe K, McIntyre L, Lamontagne F, Soth M, Herridge M, Lapinsky S, Clark E, Garg AX, Hiremath S, Klein D, Mazer CD, Richardson RM, Wilcox ME, Friedrich JO, Burns KE, Bagshaw SM. Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury. Kidney Int. 2015 Oct;88(4):897-904. doi: 10.1038/ki.2015.184. Epub 2015 Jul 8. PubMed PMID: 26154928.
    Stelfox HT, Bagshaw SM, Gao S. A retrospective cohort study of age-based differences in the care of hospitalized patients with sudden clinical deterioration. J Crit Care. 2015 Jun 1. pii: S0883-9441(15)00326-3. doi: 10.1016/j.jcrc.2015.05.018. [Epub ahead of print] PubMed PMID: 26116139.
    James MT, Pannu N, Barry R, Karsanji D, Tonelli M, Hemmelgarn BR, Manns BJ, Bagshaw SM, Stelfox HT, Dixon E. A modified Delphi process to identify process of care indicators for the identification, prevention and management of acute kidney injury after major surgery. Can J Kidney Health Dis. 2015 Apr 9;2:11. doi: 10.1186/s40697-015-0047-8. eCollection 2015. PubMed PMID: 26060575; PubMed Central PMCID: PMC4460967.
    Cardoso FS, Bagshaw SM, Abraldes JG, Kneteman NM, Meeberg G, Fidalgo P,Karvellas CJ. Comorbidities have a limited impact on post-transplant survival in carefully selected cirrhotic patients: a population-based cohort study. Ann Hepatol. 2015 Jul-Aug;14(4):505-14. PubMed PMID: 26019037.
    Darmon M, Bagshaw SM, Forni LG. Balancing the "humors" in severe sepsis: still a role for extracorporeal therapies? Intensive Care Med. 2015 Jun;41(6):1132-4. doi: 10.1007/s00134-015-3801-6. Epub 2015 May 14. PubMed PMID: 25971380.
    Cardoso FS, Karvellas CJ, Kneteman NM, Meeberg G, Fidalgo P, Bagshaw SM. Postoperative resource utilization and survival among liver transplant recipients with Model for End-stage Liver Disease score ≥ 40: A retrospective cohort study. Can J Gastroenterol Hepatol. 2015 May;29(4):185-91. PubMed PMID: 25965438; PubMed Central PMCID: PMC4444027.
    Daneman N, Rishu AH, Xiong W, Bagshaw SM, Cook DJ, Dodek P, Hall R, Kumar A, Lamontagne F, Lauzier F, Marshall JC, Martin CM, McIntyre L, Muscedere J, Reynolds S, Stelfox HT, Fowler RA; Canadian Critical Care Trials Group. Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial. Trials. 2015 Apr 18;16:173. doi: 10.1186/s13063-015-0688-z. PubMed PMID: 25903783; PubMed Central PMCID: PMC4407544.
    Heyland D, Cook D, Bagshaw SM, Garland A, Stelfox HT, Mehta S, Dodek P, Kutsogiannis J, Burns K, Muscedere J, Turgeon AF, Fowler R, Jiang X, Day AG; Canadian Critical Care Trials Group; Canadian Researchers at the End of Life Network. The Very Elderly Admitted to ICU: A Quality Finish? Crit Care Med. 2015 Jul;43(7):1352-60. doi: 10.1097/CCM.0000000000001024. PubMed PMID: 25901550.
    Fowler RA, Abdelmalik P, Wood G, Foster D, Gibney N, Bandrauk N, Turgeon AF, Lamontagne F, Kumar A, Zarychanski R, Green R, Bagshaw SM, Stelfox HT, Foster R, Dodek P, Shaw S, Granton J, Lawless B, Hill A, Rose L, Adhikari NK, Scales DC, Cook DJ, Marshall JC, Martin C, Jouvet P; Canadian Critical Care Trials Group; Canadian ICU Capacity Group. Critical care capacity in Canada: results of a national cross-sectional study. Crit Care. 2015 Apr 1;19:133. doi: 10.1186/s13054-015-0852-6. PubMed PMID: 25888116; PubMed Central PMCID: PMC4426537.
    Elhenawy AM, Meyer SR, Bagshaw SM, MacArthur RG, Carroll LJ. Role of preoperative intravenous iron therapy to correct anemia before major surgery: study protocol for systematic review and meta-analysis. Syst Rev. 2015 Mar 15;4:29. doi: 10.1186/s13643-015-0016-4. PubMed PMID: 25874460; PubMed Central PMCID: PMC4369835.
    Alobaidi R, Basu RK, Goldstein SL, Bagshaw SM. Sepsis-associated acute kidney injury. Semin Nephrol. 2015 Jan;35(1):2-11. doi: 10.1016/j.semnephrol.2015.01.002. Review. PubMed PMID: 25795495; PubMed Central PMCID: PMC4507081.
    Stammers AN, Kehler DS, Afilalo J, Avery LJ,Bagshaw SM, Grocott HP, Légaré JF, Logsetty S, Metge C, Nguyen T, Rockwood K, Sareen J, Sawatzky JA, Tangri N, Giacomantonio N, Hassan A, Duhamel TA, Arora RC. Protocol for the PREHAB study-Pre-operative Rehabilitation for reduction of Hospitalization After coronary Bypass and valvular surgery: a randomised controlled trial. BMJ Open. 2015 Mar 9;5(3):e007250. doi: 10.1136/bmjopen-2014-007250. PubMed PMID: 25753362; PubMed Central PMCID: PMC4360727.
    Bagshaw SM, Stelfox HT, Johnson JA, McDermid RC, Rolfson DB, Tsuyuki RT, Ibrahim Q, Majumdar SR. Long-term association between frailty and health-related quality of life among survivors of critical illness: a prospective multicenter cohort study. Crit Care Med. 2015 May;43(5):973-82. doi: 10.1097/CCM.0000000000000860. PubMed PMID: 25668751.
    Heyland DK, Dodek P, Mehta S, Cook D, Garland A, Stelfox HT, Bagshaw SM, Kutsogiannis DJ, Burns K, Muscedere J, Turgeon AF, Fowler R, Jiang X, Day AG; Canadian Critical Care Trials Group and Canadian Researchers at End of Life Network (CARENET). Admission of the very elderly to the intensive care unit: family members' perspectives on clinical decision-making from a multicenter cohort study. Palliat Med. 2015 Apr;29(4):324-35. doi: 10.1177/0269216314566060. Epub 2015 Feb 2. PubMed PMID: 25645668.
    Prowle JR, Calzavacca P, Licari E, Ligabo EV, Echeverri JE, Bagshaw SM, Haase-Fielitz A, Haase M, Ostland V, Noiri E, Westerman M, Devarajan P, Bellomo R. Combination of biomarkers for diagnosis of acute kidney injury after cardiopulmonary bypass. Ren Fail. 2015 Apr;37(3):408-16. doi: 10.3109/0886022X.2014.1001303. Epub 2015 Jan 14. PubMed PMID: 25585949; PubMed Central PMCID: PMC4544762.
    Wald R, McArthur E, Adhikari NK, Bagshaw SM, Burns KE, Garg AX, Harel Z, Kitchlu A, Mazer CD, Nash DM, Scales DC, Silver SA, Ray JG, Friedrich JO. Changing incidence and outcomes following dialysis-requiring acute kidney injury among critically ill adults: a population-based cohort study. Am J Kidney Dis. 2015 Jun;65(6):870-7. doi: 10.1053/j.ajkd.2014.10.017. Epub 2014 Dec 18. PubMed PMID: 25533599.
    Bailey M, McGuinness S, Haase M, Haase-Fielitz A, Parke R, Hodgson CL, Forbes A, Bagshaw SM, Bellomo R. Sodium bicarbonate and renal function after cardiac surgery: a prospectively planned individual patient meta-analysis. Anesthesiology. 2015 Feb;122(2):294-306. doi: 10.1097/ALN.0000000000000547. PubMed PMID: 25501691.
    Downar J, You JJ, Bagshaw SM, Golan E, Lamontagne F, Burns K, Sridhar SK, Seely A, Meade MO, Fox-Robichaud A, Cook D, Turgeon AF, Dodek P, Xiong W, Fowler R; Canadian Critical Care Trials Group. Nonbeneficial treatment Canada: definitions, causes, and potential solutions from the perspective of healthcare practitioners*. Crit Care Med. 2015 Feb;43(2):270-81. doi: 10.1097/CCM.0000000000000704. PubMed PMID: 25377017.
    Clark EG, Bagshaw SM. Unnecessary renal replacement therapy for acute kidney injury is harmful for renal recovery. Semin Dial. 2015 Jan-Feb;28(1):6-11. doi: 10.1111/sdi.12300. Epub 2014 Oct 30. PubMed PMID: 25359104.
    Romanovsky A, Azevedo LC, Meeberg G, Zibdawi R, Bigam D, Bagshaw SM. Serum sodium shift in hyponatremic patients undergoing liver transplantation: a retrospective cohort study. Ren Fail. 2015 Feb;37(1):37-44. doi: 10.3109/0886022X.2014.975102. Epub 2014 Oct 27. PubMed PMID: 25347235.
    Ethgen O, Schneider AG, Bagshaw SM, Bellomo R, Kellum JA. Economics of dialysis dependence following renal replacement therapy for critically ill acute kidney injury patients. Nephrol Dial Transplant. 2015 Jan;30(1):54-61. doi: 10.1093/ndt/gfu314. Epub 2014 Oct 17. PubMed PMID: 25326472; PubMed Central PMCID: PMC4286762.
    Cardoso FS, Karvellas CJ, Kneteman NM, Meeberg G, Fidalgo P, Bagshaw SM. Postoperative Resource Utilization and Survival among Liver Transplant Recipients with MELD greater or equal to 40: A Retrospective Cohort Study. Can J Gastroenterol Hepatol. 2015 May;29(4):185-91. IF 2.0.
    MacIntyre E, Asadi L, Mckim DA, Bagshaw SM. Clinical outcomes associated with home mechanical ventilation: A systematic review. Can Respir J. 2015 Sep 30. pii: 17132. [Epub ahead of print] No abstract available.
    Rewa O, Mottes T, Bagshaw SM. Quality measures for acute kidney injury and continuous renal replacement therapy. Curr Opin Crit Care. 2015 Dec;21(6):490-9. doi: 10.1097/MCC.0000000000000262. PMID: 26539922
    Villeneuve PM, Clark EG, Sikora L, Sood MM, Bagshaw SMHealth-related quality-of-life among survivors of acute kidney injury in the intensive care unit: a systematic review. Intensive Care Med. 2015 Dec 1 (PMID: 26626062).
    Heyland DK, Garland A, Bagshaw SM, Cook D, Rockwood K, Stelfox HT, Dodek P, Fowler RA, Turgeon AF, Burns K, Muscedere J, Kutsogiannis J, Albert M, Mehta S, Jiang X, Day AG. Recovery after critical illness in patients aged 80 years or older: a multi-center prospective observational cohort study. Intensive Care Med. 2015 Nov;41(11):1911-20 (PMID: 26306719).
     Wald R, Adhikari NK, Smith OM, Weir MA, Pope K, Cohen A, Thorpe K, McIntyre L, Lamontagne F, Soth M, Herridge M, Lapinsky S, Clark E, Garg AX, Hiremath S, Klein D, Mazer CD, Richardson RM, Wilcox ME, Friedrich JO, Burns KE, Bagshaw SM; Canadian Critical Care Trials Group. Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury. Kid Int 2015: ePub July 8, 2015 (PMID: 26154928).
     Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, Edipidis K, Forni LG, Gomersall CD, Govil D, Honoré PM, Joannes-Boyau O, Joannidis M, Korhonen AM, Lavrentieva A, Mehta RL, Palevsky P, Roessler E, Ronco C, Uchino S, Vazquez JA, Vidal Andrade E, Webb S, Kellum JA. Epidemiology of acute kidney injury in critically ill patients: the multi-national AKI-EPI study. Intensive Care Med 2015;41(8):1411-23 (PMID: 26162677).
     Avezedo LC, de Souza IA, Zygun DA, Stelfox HT, Bagshaw SMNighttime Discharge from the Intensive Care Unit is Associated with Increased In-Hospital Mortality: A Multi-Center Retrospective Cohort Study. BMC Health Services Research 2015: BMC Health Serv Res. 2015 Sep 14;15:378. doi: 10.1186/s12913-015-1044-4. (PMID: 26369933).
    Bagshaw SM, Stelfox HT, Johnson JA, McDermid RC, Rolfson DB, Tsuyuki RT, Ibrahim Q, Majumdar SR. Long-term association between frailty and health-related quality-of-life among survivors of critical illness: A prospective multi-centre cohort study. Crit Care Med 2015; 43(5): 973-82. (PMID: 2566751).
    Downar J, You JJ, Bagshaw SM, Golan E, Sridar SK, Burns K, Seely A, Meade MO, Fox-Robichaud A, Cook D, Lamontagne F, Turgeon AF, Dodek P, Xiong W, Fowler R, Canadian Critical Care Trials Group. Non-beneficial Treatment in Canada: Definitions, Causes, and Potential Solutions from the Perspective of Healthcare Practitioners*.Crit Care Med 2015;43(2):270-81. (PMID: 25377017).
    Clark E, Molnar AO, Joannes-Boyau O, Honoré PM, Sikora L, Bagshaw SMHigh-volume hemofiltration for septic acute kidney injury: a systematic review and meta-analysis. Crit Care. 2014;18(1):R7. (PMID: 24398168). Fidalgo P, Ahmed M, Meyer SR, Lien D, Weinkauf J, Kapasi A, Cardoso FS, Jackson K, Bagshaw SM. Association between transient acute kidney injury and morbidity and mortality after lung transplantation: A retrospective cohort study. J Crit Care. 2014: ePub Jul 31. (PMID: 25138690).
    Bagshaw SM, Stelfox HT, McDermid RC, Rolfson D, Tsuyuki RT, Baig N, Artiuch B, Ibrahim Q, Stollery DE, Rokosh E, Majumdar SR. Association Between Frailty and Short and Long-Term Outcomes In Critically Ill Patients: A Multi-Centre Prospective Cohort Study. CMAJ 2014;186(2):E95-102. Epub 2013 Nov 25. (PMID: 24277703).

    Abstract

    Stelfox T, Niven D, Bagshaw S, McKenzie E, Potestio M, Clement F, Zygun D, on behalf of the Critical Care Strategic Clinical Network (CCSCN), *University of Calgary, University of Alberta, Alberta Health Services “Stakeholder engagement to identify priorities for improving the quality and value of care provided to critically ill patients” presented Abstract at 35th International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium March, 2015.
  • Sean van Diepen
    Senaratne J., Norris C., Graham M., Nagendran J., Freed D., Afilalo J., Van Diepen S. (2015) Clinical and angiographic outcomes associated with surgical revascularization of angiographically borderline 50-69% coronary artery stenosis.
    Senaratne J., Van Diepen S. Management of Endocarditis In R. Hyzy (Ed.), Evidence based critical care: A case study approach. Willowick OH: Springer Science. (Accepted. In Press).
    Hill T, Means G, MD, van Diepen S, Paul T, Katz JN. Cardiovascular critical care: a perceived deficiency among US trainees. Critical Care Medicine 2015; 43 (9): 1853-1858.
    Tedjasaputra V, Bryan TL, van Diepen S, Moore LE, Bouwsema MM, Welsh RC, Petersen SR, Stickland MK. Dopamine receptor blockade improves pulmonary gas exchange but decreases exercise performance in healthy humans. The Journal of Physiology 2015; 593.14 (2015) pp 3147–3157.
    Pauley E, Lishmanov A, Schumann S, Gala GJ, van Diepen S, Katz JN. Delirium is a Robust Predictor of Morbidity and Mortality among Critically Ill Patients Treated in the Cardiac Intensive Care Unit. American Heart Journal 2015; 170(1):79- 86.
    van Diepen S, Bakal J, Lin M, Kaul P, McAllister F, Ezekowitz JA. Variation in critical care unit admission rates and outcomes for patients with acute coronary syndromes or heart failure among high and low volume cardiac hospitals. J Am Heart Assoc 2015; 4(3): e001708 doi:10.1161/JAHA.114.001708.
    van Diepen S, Granger CB, Jacka M, Gilchrist IC Morrow DA, Katz JN. The Unmet Need for Addressing Cardiac Issues in Intensive Care Research. Critical Care Medicine 2015; 43(1):128-134.
    van Diepen S. Is Coronary Intensive Care Unit Volume a Quality Metric? J Am Heart Assoc 2015; 4(6).
    van Diepen S, Tricoci P, Podder M, Aylward PE, Held C, van de Werf F, Strony J, Mahaffey KW, Harrington RA, Armstrong PW. Efficacy and safety of vorapaxar in NSTE ACS patients undergoing non-cardiac surgery. Journal of the American Heart Association 2015 (in press).
    Fang ZA, van Diepen S, and the RAH and UAH cardiac arrest teams. Successful Inter-Hospital Transfer for Extracorporeal Membrane Oxygenation after an Amniotic Fluid Embolism Induced Cardiac Arrest. Canadian Journal of Anesthesia. 2015 (in press).
    van Diepen S; Granger CB; Jacka M; Gilchrist IC; Morrow DA; Katz JN. Critical Care Medicine. 43(1):128-34, 2015 Jan.
    Le May M, van Diepen S, Liszkowski M, Schnell G, Tanguay JF, Granger CB, Ainsworth C, Diodati JG, Fam N, Haichin R, Jassal D, MD, Overgaard C, Tymchak CT, Tyrrell B, Osborne C, Wong G. Perspective on Canadian Coronary Care Units: Recommendations for Organizational, Staffing, and Educational Transformation. Canadian Journal of Cardiology 2015 DOI: http://dx.doi.org/10.1016/j.cjca.2015.11.021.
    Vavalle JP, van Diepen S, Lopes RD, Clare RC, Westerhout CW, Hochman JS, Weaver WD, Mehta RH, Pieper KS, Patel MR, Armstrong PW, Granger CB. Renal failure in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention: Predictors, clinical and angiographic features, and outcomes. American Heart Journal 2015 doi: http://dx.doi.org/10.1016/j.ahj.2015.12.001.
    Hill T, Means G, MD, van Diepen S, Paul T, Katz JN. Cardiovascular critical care: a perceived deficiency among US trainees. Critical Care Medicine 2015; 43 (9): 1853-1858.
    Tedjasaputra V, Bryan TL, van Diepen S, Moore LE, Bouwsema MM, Welsh RC, Petersen SR, Stickland MK. Dopamine receptor blockade improves pulmonary gas exchange but decreases exercise performance in healthy humans.The Journal of Physiology 2015; 593.14 (2015) pp 3147–3157.
    Pauley E, Lishmanov A, Schumann S, Gala GJ, van Diepen S, Katz JN. Delirium is a Robust Predictor of Morbidity and Mortality Among Critically Ill Patients Treated in the Cardiac Intensive Care Unit. American Heart Journal 2015; 170(1):79-86.
    van Diepen S, Bakal J, Lin M, Kaul P, McAllister F, Ezekowitz JA. Variation in critical care unit admission rates and outcomes for patients with acute coronary syndromes or heart failure among high and low volume cardiac hospitals. J Am Heart Assoc 2015; 4(3): e001708 doi:10.1161/JAHA.114.001708.
    van Diepen S, Graham MM, Nagendran J, Norris CM. Predicting Cardiovascular Intensive Care Unit Readmission after Cardiac Surgery: Derivation and Validation of the APPROACH CVICU Clinical Prediction Model from 10,799 Surgical Cases. Critical Care 2014, 18; 651 doi:10.1186/s13054-014-0651-5.
    Senaratne JM, Norris C, Graham m, Najendran J, Freed D, Afilalo J, van Diepen S. Routine coronary artery bypass of angiographically borderline coronary artery stenosis is not associated with improved survival. European Journal of Cardio-thoracic Surgery 2016; 1-7: http://doi:10.1093/ejcts/ezw005.
    Fang ZA, van Diepen S, and the RAH and UAH cardiac arrest teams. Successful Inter-Hospital Transfer for Extracorporeal Membrane Oxygenation after an Amniotic Fluid Embolism Induced Cardiac Arrest. Canadian Journal of Anesthesia. 2016; 63:507-508.
    van Diepen S. Is Coronary Intensive Care Unit Volume a Quality Metric? J Am Heart Assoc 2015; 4(6).
    van Diepen S, Lin M, Bakal JA, McAlister FA, Kaul P, Katz JN, Fordyce C, Southern DA, Graham MM, Wilton SB, Newby LK, Granger CB, Ezekowitz JA. Do Patients with Uncomplicated Non-ST Segment Acute Coronary Syndromes Require Admission to Critical Care Units? American Heart Journal 2016 DOI: http://dx.doi.org/10.1016/j.ahj.2015.11.020.
    Le May M, van Diepen S, Liszkowski M, Schnell G, Tanguay JF, Granger CB, Ainsworth C, Diodati JG, Fam N, Haichin R, Jassal D, MD, Overgaard C, Tymchak CT, Tyrrell B, Osborne C, Wong G. Perspective on Canadian Coronary Care Units: Recommendations for Organizational, Staffing, and Educational Transformation. Canadian Journal of Cardiology 2015 DOI: http://dx.doi.org/10.1016/j.cjca.2015.11.021.
    van Diepen S, Tricoci P, Podder M, Aylward PE, Held C, van de Werf F, Strony J, Mahaffey KW, Harrington RA, Armstrong PW. Efficacy and safety of vorapaxar in NSTE ACS patients undergoing non-cardiac surgery. Journal of the American Heart Association 2015; ;4:e002546 doi: 10.1161/JAHA.115.002546.
    Vavalle JP, van Diepen S, Lopes RD, Clare RC, Westerhout CW, Hochman JS, Weaver WD, Mehta RH, Pieper KS, Patel MR, Armstrong PW, Granger CB. Renal failure in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention: Predictors, clinical and angiographic features, and outcomes. American Heart Journal 2015 doi: http://dx.doi.org/10.1016/j.ahj.2015.12.001.
    Hill T, Means G, MD, van Diepen S, Paul T, Katz JN. Cardiovascular critical care: a perceived deficiency among US trainees. Critical Care Medicine 2015; 43 (9): 1853-1858.
    Tedjasaputra V, Bryan TL, van Diepen S, Moore LE, Bouwsema MM, Welsh RC, Petersen SR, Stickland MK. Dopamine receptor blockade improves pulmonary gas exchange but decreases exercise performance in healthy humans. The Journal of Physiology 2015; 593.14 (2015) pp 3147–3157.
    Pauley E, Lishmanov A, Schumann S, Gala GJ, van Diepen S, Katz JN. Delirium is a Robust Predictor of Morbidity and Mortality Among Critically Ill Patients Treated in the Cardiac Intensive Care Unit. American Heart Journal 2015; 170(1):79-86.
    van Diepen S, Bakal J, Lin M, Kaul P, McAllister F, Ezekowitz JA. Variation in critical care unit admission rates and outcomes for patients with acute coronary syndromes or heart failure among high and low volume cardiac hospitals. J Am Heart Assoc 2015; 4(3): e001708 doi:10.1161/JAHA.114.001708.
    van Diepen S, Granger CB, Jacka M, Gilchrist IC Morrow DA, Katz JN. The Unmet Need for Addressing Cardiac Issues in Intensive Care Research. Critical Care Medicine 2015; 43(1):128-134.
    van Diepen S, Graham MM, Nagendran J, Norris CM. Predicting Cardiovascular Intensive Care Unit Readmission after Cardiac Surgery: Derivation and Validation of the APPROACH CVICU Clinical Prediction Model from 10,799 Surgical Cases. Critical Care 2014, 18; 651 doi:10.1186/s13054-014-0651-5.
    van Diepen S, Hernandez AD, Podder M, Westerhout CM, Armstong PW, McMurray JJV, Eapen ZJ, Califf RM, Starling RC, O’Connor CM, Ezekowitz JA. Acute Decompensated Heart Failure Patients Admitted to Critical Care Units: Insights from ASCEND-HF. International Journal of Cardiology 2014; 77: 840-846.
    van Diepen S, Youngson E, Ezekowitz JA, McAlister FA. Which risk score best predicts peri-operative outcomes in non-valvular atrial fibrillation patients undergoing non-cardiac surgery? American Heart Journal 2014; 168(1):60-67.
    van Diepen S, Brennan JM, Hafley GE, Reyes ER, Allen KB, Ferguson TB, Peterson ED, Williams JB, Gibson CM, Mack MJ, Kouchoukos NT, Alexander JH, Lopes RD. Device Specific Outcomes in Patients Undergoing Endoscopic Vein Graft Harvesting for Coronary Artery Bypass Surgery: Results from PREVENT-IV. Annals of Surgery 2014; 260(2): 402-408.
    van Diepen S, Chen AY, Wang T, Alexander K, Ezekowitz JA, Peterson ED, Roe MT. Influence of Heart Failure Symptoms and Ejection Fraction on Short- and Long-term Outcomes for Older Patients with Non-ST-Segment Elevation Myocardial Infarction. American Heart Journal 2014; 167(2): 267-273.
    van Diepen S, Reynolds HR, Stebbins A, Lopes RD, Džavík V, Ruzyllo W, Geppert A, Widimsky P, Ohman EM, Parrillo JE, Dauerman HL, Baran DA, Hochman JS, Alexander JH. Incidence and outcomes associated with early heart failure pharmacotherapy in patients with ongoing cardiogenic shock. Critical Care Medicine 2014; 42(2):281-288.

    Abstract

    Routine coronary artery bypass of angiographically borderline coronary artery stenoses is not associated with improved survival. Senaratne J., Norris C., Graham M., Nagendran J., Freed D., Afilalo J., Van Diepen S. (2015) Journal of the American College of Cardiology. 65(10S):A1587
    Do Patients with Uncomplicated Non-ST Segment Acute Coronary Syndromes Require Admission to Critical Care Units? van Diepen S, Lin M, Bakal JA, McAlister FA, Kaul P, Katz JN, Fordyce C, Southern DA, Graham MM, Wilton SB, Newby LK, Granger CB, Ezekowitz JA. Circulation 2015; 132:A17437.
    Identifying Patients with Acute Heart Failure who Require a Critical Care Admission Raslan IR, Westerhout CM, Ezekowitz JA, Hernandez AF, Starling RC, O’Connor C, Armstrong PW, van Diepen S: ASCEND-HF Insights. Circulation. 2015;132:A18407.
    Regional Variation in Out-Of-Hospital Cardiac Arrest Survival in the United States. Circulation. Girotra S, van Diepen S, Nallamothu BK, Carrel MK, Vellano K, Anderson ML McNally B, Abella B, Sasson C, Chan PS.: Cardiovasc Qual Outcomes 2015; 2015; 8: A10.
    The clinical and angiographic outcomes in coronary artery bypass surgery using grafts with multiple versus single distal targets. Alherbish A, Norris C, Najendran J, Graham M, van Diepen S. J Am Coll Cardiol 2015; 65 (10) Supplement A: 411.
    Raslan IR, Westerhout CM, Ezekowitz JA, Hernandez AF, Starling RC, O’Connor C, Armstrong PW, van Diepen S. Identifying Patients with Acute Heart Failure who Require a Critical Care Admission: ASCEND-HF Insights. Circulation. 2015;132:A18407.

    Book Chapters

    Senaratne JM, van Diepen S. Management of Endocarditis In: Hyzy R, Morrow D, eds. Evidence Based Critical Care: A Case Study Approach. 2015 (in press).
    Senaratne JM, van Diepen S. Management of Endocarditis In: Hyzy R, Morrow D, eds. Evidence Based Critical Care: A Case Study Approach. 2015 (in press).
  • Wendy Sligl
    Sligl WI, Dragan T, Smith SW. Nosocomial gram-negative bacteremia in intensive care: epidemiology, antimicrobial susceptibilities and outcomes. Int J Infect Dis 2015 Jul 6, doi10.1016/j.ijid.2015.06.024 [Epub ahead of print].
    McFarlane A, Sligl W. The Value of Macrolide-Based Regimens for Community-Acquired Pneumonia. Curr Infect Dis Rep. 2015 Dec;17(12):50. doi: 10.1007/s11908-015-0507-4.

Clinical Faculty Publications

  • 2015

    Peer-Reviewed: Invited Reviews

    Senaratne J., Raggi P. (2015) Screening for aortic aneurysms in patients with coronary artery disease: Should it be done? Expert Review of Cardiovascular Therapy. 13:735-737.
    MacIntyre, E. Clinical Outcomes Associated with Home Mechanical Ventilation: A Scoping Review” Canadian Respiratory Journal.
    Macala, K. Preclinical testing of novel treatment strategies for septic shock in a mouse model of advanced age.
    Cheung HJ, Cheung L. Coaching patients during pulmonary function testing: A practical guide. Can J Respir Ther. 2015 Summer;51(3):65-8. Review. PubMed PMID: 26283871; PubMed Central PMCID: PMC4530837. 
    Laratta C, Cheung L. Venous air embolism from blunt chest trauma. Can Respir J. 2015 Jul-Aug;22(4):199-200. PubMed PMID: 26252532; PubMed Central PMCID:PMC4530850. 
    Li P, Cheung L, Chiu B. Early bronchus-associated lymphoid tissue lymphoma diagnosed using immunoglobulin heavy chain molecular testing. Can Respir J. 2015 Jul 27. pii: 16950. [Epub ahead of print] PubMed PMID: 26214007. 
    Douma MJ, Bara G, ODochartiagh D, Brindley PG. Insertion of Two Intraosseous Needles into a Single Humerus: a feasibility and simulation study. Prehosp Disaster Med. Publication pending 2015. 
    Gillman L, Martin D, Brindley PGWidder S, Engels PT, French C. S.T.A.R.T.T. Plus – Addition of Pre-Hospital Personnel to a National Multi-disciplinary Crisis Resource Management Trauma Team Training Course. Can J Surg. Dec 2015;58 (6):010915-10915. PubMed PMID 26574706. 
    Gillmann L, Brindley PGPaton-Gay JD, Engels PT, Park J, Vergis A, Widder S. Standardized Trauma And Resuscitation Team Training (S.T.A.R.T.T.) Course - Evolution Of A Multidisciplinary Trauma Crisis Resource Management Simulation Course. Am J Surg. 2015 Oct; PubMed PMID 26507290 [Epub ahead of print]. 
    Sprague E, Reynolds S, Brindley P.G. Isolation Precautions: Are they worth it? Can J Resp 2015 In press.
    Brindley P.G. Communicating About Difficult Medical Decisions: The Most Dangerous Procedure in the Hospital? ICU management. 2015; 15:2: 80-82. 
    Beed M, Brindley P.G. Code Blues. CHEST 2015;148(4):1121. doi:10.1378/chest.15-0989. 
    Clarke D, O’Kelly C, Beed M, Brindley P.G. Acute Care S.I.N.S: Surgical Insights for the Non Surgeon. Invited series for CJGIM. Part 13: Spinal SINS. Publication pending CJGIM 2015. 
    Clarke D, O’Kelly C, Beed M, Brindley P.G. Acute Care S.I.N.S: Surgical Insights for the Non Surgeon. Invited series for CJGIM. Part 12: Central Nervous System. Publication pending CJGIM 2015. 
    Beed M, Khadaroo RBrindley P.G. Acute Care S.I.N.S: Surgical Insights for the Non Surgeon. Invited series for CJGIM. Part 11: Cardiothoracic. Publication pending 2015.
    Mapiour D, Brindley P.GBrisebois RKhadaroo R. Acute Care S.I.N.S: Surgical Insights for the Non Surgeon. Invited series for CJGIM. Part 10: Trauma. CJGIM 2015;10(1):6-19.
    Douma MJ, ODochartiagh D, Corry A, Brindley PG. How Intravenous Nitroglycerine Transit Time from Bag to bloodstream can be affected by infusion technique: a simulation study. Emerg Med J. 2015;32(6):498-500. 
    Beed M, de Beer T, Brindley PG. Two Decades of British Media Coverage Regarding Do-Not-Resuscitate Orders: lessons for acute care clinicians. Resuscitation 2015;86:31-7. 
    Arabi YM, Aldawood AS, Haddad SH, Al-Dorzi HM, Tamim HM, Jones G, Mehta S, McIntyre L, Solaiman O, Sakkijha MH, Sadat M, Afesh L; PermiT Trial Group. Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults. N Engl J Med. 2015 Jun 18;372(25):2398-408. doi: 10.1056/NEJMoa1502826. Epub 2015 May 20. Erratum in: N Engl J Med. 2015 Sep 24;373(13):1281. PubMed PMID: 25992505. 
    Lacroix J, Hébert PC, Fergusson DA, Tinmouth A, Cook DJ, Marshall JC, Clayton L, McIntyre L, Callum J, Turgeon AF, Blajchman MA, Walsh TS, Stanworth SJ, Campbell H, Capellier G, Tiberghien P, Bardiaux L, van de Watering L, van der Meer NJ, Sabri E, Vo D; ABLE Investigators; Canadian Critical Care Trials Group. Age of transfused blood in critically ill adults. N Engl J Med. 2015 Apr 9;372(15):1410-8. doi: 10.1056/NEJMoa1500704. Epub 2015 Mar 17. PubMed PMID: 25853745.
    Ali TF, Warkentin LM, Gazala S, Wagg, AS, Padwal RS, Khadaroo RG. Self-Reported Outcomes in Individuals Aged 65 and Older Admitted for Treatment to an Acute Care Surgical Service: A 6-Month Prospective Cohort Study. Journal of the American Geriatrics Society 63(11): 2388-94, Nov 2015. 
    Khadaroo RG, Padwal RS, Wagg AS, Clement F, Warkentin LM, Holroyd-Leduc J. Optimizing senior's surgical care - Elder-friendly Approaches to the Surgical Environment (EASE) Study: rationale and objectives. BMC Health Services Research 15(1):338 21 Aug 2015 E-released).
    Beed M, Khadaroo RG, Singh G, Brindley PG. Chapter 11 - Cardiothoracic: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine 10(2): 6-19, 2015.
    Mapiour D, Brindley PGBrisebois RKhadaroo RGBrindley PG. Chapter 10 - Trauma: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine 10(1): 6-17, 2015. 
    Lees M, Merani S, Tauh K, Khadaroo RG. Perioperative Factors Predicting Poor Outcome in Elderly Patients Following Emergency General Surgery: A Multivariate Analysis. Canadian Journal of Surgery 58(5): 312-7, Oct 2015.
    Kinnaird A, Fairey A, Rourke K, Khadaroo RGBrindley PG. Chapter 9 - Urology: Surgical Insights for the Non-Surgeon. Canadian Journal of General Internal Medicine 9(4): 7, 2015.
    Ali TF, Warkentin LM, Gazala S, Wagg AS, Padwal RS, Khadaroo RG, Acute Care and Emergency Surgery (ACES) Group. Self-Reported Outcomes in Individuals Aged 65 and Older Admitted for Treatment to an Acute Care Surgical Service: A 6-Month Prospective Cohort Study. J Am Geriatr Soc. 2015 Nov;63(11):2388-94. 
    Djogovic D, MacDonald S, Wensel A, Green R, Loubani O, Archambault P, Bordeleau S, Messenger D, Szulewski A, Davidow J, Kircher J, Gray S, Smith K, Lee J, Benoit JM, Howes D. Vasopressor and Inotrope Use in Canadian Emergency Departments: Evidence Based Consensus Guidelines. Canadian Journal of Emergency Medicine 2015; 17(S1):1-16 and CJEM 2015; 17(1):1-2.

    Abstract

    Complex Abdominal Wall Reconstruction: Recommendations from the Canadian Abdominal Wall Reconstruction Group. Hameed et al. Presentation TAC Apr 10, 2015 Calgary. 
    Paravertebral block vs Sham in the setting of a multimodal analgesia regimen and total intravenous anesthesia foor mastectomy: a prospective, randomized, controlled trial. D Lam, J Green… M Stephens et al. American Society of Regional Anesthesia. Abstract May 2015. 
    Pre-operative pregnancy testing (POPT) and the undiagnosed pregnancy rate in an elective gynaecology surgery population. Douglas et al. Clinical Obsetetrics, Gynecology and Reproductive Medicine, 2015 1(2): 43-46. 
    Fortis S, Khadaroo RG, Haitsma J, Zhang H. Osteopontin is associated with inflammation and mortality in a mouse model of polymicrobial sepsis. Acta Anaesthesiologica Scandinavica. 59 (2): 170-5, Feb 2015.
    AlMalki N, Salim SY, Emberg M, Churchill TA, Khadaroo RG. OSMR Deficiency Provides Protection in Sepsis-Induced Morbidity & Mortality in both Young and Adult Mice. American College of Surgeons, 221 (4) e8, Oct 2015.
    Alkathiri O, Salim SY, Warkentin L, Churchill TA, Tandon P, Khadaroo RG. Ultrasound Diagnosis of Sarcopenia is Predictive of Post-Operative Complications. American College of Surgeons, 221 (4) e18, Oct 2015.
    AlMalki N, Salim SY, Churchill TA, Khadaroo RG. Deficiency in Oncostatin M Receptor Results in Improved Survival in Older Mice Following Sepsis Through Down-Regulation of IL-10. Surgical Infections, 16 (S1), S-10, Apr 2015.
    Salim SY, AlMalki N, Khadaroo RG, Churchill T. Oncostatin M Receptor Deficiency Results in Attenuated Peritoneal Inflammatory response enhanced survival in a murine sepsis model. Surgical Infections, 16 (S1), S-26, Apr 2015.
    Salim SY, Al-Malki N, Churchill TA, Khadaroo RG. Oncostatin M Receptor Deficiency Protects Against Sepsis in Older Mice. Academic Surgical Congress, #61.16, 72, Feb 2015.
    Warkentin LM, Ali TF, Gazala S, Wagg A, Padwal R, Khadaroo RG. Change in Functional Status and Quality of Life in Elders Admitted to an Acute Care Surgery Service. Academic Surgical Congress, #64.19 75, Feb 2015.

    Book Chapters

    Brindley P.G. Communication. In: Webb, A Ed. The Handbook of Intensive Care Organization and Management (second edition). Publication pending 2015. 
    Brindley P.G. Widder S, Gillman L. Developing Multidisciplinary Simulation Scenarios. In: L Gillman, S Widder, M Blaivas D Karakitosis Eds; Trauma Team Dynamics. Springer Press. Publication pending 2015.
    Widder S, Koltoth D, Brindley PG. Principles of Crisis Resource Management – Leadership theories skills and application. In: L Gillman, S Widder, M Blaivas D Karakitosis Eds; Trauma Team Dynamics. Springer Press. Publication pending 2015.
    Brindley P.G. Teamwork and Communication. In: L Gillman, S Widder, M Blaivas, D Karakitosis Eds; Trauma Team Dynamics. Springer Press. Publication pending 2015. 
    Brindley P.G, Tse A. Human Performance in Trauma; practical insights. In: L Gillman, S Widder, M Blaivas D Karakitosis Eds; Trauma Team Dynamics. Springer Press. Publication pending 2015. 
    Widder S, Kolthoff D, Brindley P (Editors). Trauma Team Dynamics (Textbook). Chapter 3: Leadership Theories. Springer Publishing. 2015.
    Gillman L, Widder S, Blavais M, Karaksitos D (Editors). Trauma Team Dynamics (Textbook). Chapter 5: Leadership in Trauma. Springer Publishing. 2015.
    Gillman L, Widder S, Blavais M, Karaksitos D (Editors). Trauma Team Dynamics (Textbook). Chapter 14: Quality Improvement in Trauma. Springer Publishing. 2015.
    Gillman L, Widder S, (Editors). Trauma Team Dynamics (Textbook). Chapter 39: Multiple Choice Review Questions. Springer Publishing. 2015.

    Letters to the Editor

    Beed M, Brindley PG. Do Not Resuscitate and the Intensive Care Unit: time to talk. Br J Anaesth 2015 114 (4): 706-707. 2. 
    Brindley P.G. Improving teamwork in anaesthesia and critical care: Perhaps there really is no "I" In ICU. B J Anaesth 2015;114:350-1.