The Brain Power Lab

Mission Statement

The principal objective of the BrainPowerLab is to delineate the molecular processes underlying the causes and progression of infectious and inflammatory diseases of the nervous system. By elucidating these fundamental mechanisms, we aim to aid translation to improved patient care, including diagnostic tools and treatments, for people affected by these disorders. The laboratory’s chief diseases of interest include HIV infection of the nervous system and multiple sclerosis.

Areas of Research

  • Retroviral infections of the nervous system
  • Neuroimmunology and Neuroinflammation
  • Neural Cell survival
  • Neuropathogenesis
  • Emerging Neurologic Infections

 


   

Lab Techniques

  • Real -time RT-PCR
  • Molecular cloning
  • Animal models of MS and NeuroAIDS
  • Immunocytochemistry / neuropathology
  • siRNA development
  • DNA microarray
  • Viral vector-mediated gene expression
  • Immunoblotting
  • Electrophysiology (patch clamp)
  • Neurobehavioural analysis (animals and humans)
  • Primary cell culture
  • Cell proliferation assays
  • FACS
  • Reverse transcriptase assays
  • microRNA analysis
  • Deep sequencing
  • Calcium imaging