Brain Power Lab Publications

Our researchers share their work with the medical community through publication in a number of reputable journals. A selection of recent work is listed below.

Peroxisome injury in multiple sclerosis: protective effects of 4-phenylbutyrate in CNS-associated macrophages. 

Roczkowsky A, Doan MAL, Hlavay B, Mamik MK, Branton WG, McKenzie BA, Saito LB, Schmitt L, Eitzen G, Di Cara F, Wuest M, Wuest F, Rachubinski R, Power C*  J Neurosci. 2022 Aug 8;42(37):7152-65. doi: 10.1523/JNEUROSCI.0312-22.2022. Online ahead of print. PMID: 35940876

Microbial molecule ingress promotes neuroinflammation and brain CCR5 expression in persons with HIV-associated neurocognitive disorders. 

Branton WG, Fernandes JP, Mohammadzadeh N, Doan MAL, Laman JD, Gelman BB, Fagrough Z, Kondova I, Mooij P, Koopman G, Power C*. Brain Behavior and Immunity (in press)

Lentiviral infections persist in brain despite effective antiretroviral therapy and neuroimmune activation. 

Mohammadzadeh N, Roda W, Branton WG, Clain J, Rabezanahary H, Zghidi-Abouzid O, Gelman BB, Angel JB, Cohen EA, Gill MJ, Li M, Estaquier J, Power C*. mBio. 2021 Dec 21;12(6):e0278421

Infection of glia by human pegivirus suppresses peroxisomal and antiviral signaling pathways. 

 Doan MAL, Roczkowsky A, Smith M, Blevins G, van Landeghem FKH, Gelman BB, Branton WG, Stapleton JT, Hobman TC, Power C* J Virol. 2021 Sep 15:JVI0107421.

Acute and chronic neurologic disorders in COVID-19: potential mechanisms of disease.

Balcom E, Nath A, Power C*. Brain. 2021 Aug 16 doi: 10.1093/brain/awab302.

Differential disease phenotypes and progression in relapsing-remitting multiple sclerosis: comparative analyses of single Canadian and Saudi Arabian clinics.

Alluqmani M, Roda W, Qqrmli M, Blevins G, Giuliani F, Power C*. BMC Neurology

Predictive variables for peripheral neuropathy in treated HIV-1 infection revealed by machine learning.

Tu W, Johnson E, Fujiwara E, Gill MJ, Kong LL, Power C*. AIDS 2021 May 24. doi: 10.1097.

Progressive multifocal leukoencephalopathy and Creutzfeldt - Jakob disease: Population-wide incidences, co-morbidities, costs of care, and outcomes.

Bakal JA, Charlton CL, Hlavay B, Jansen GH, Svenson LW, Power C*. J NeuroVirol 2021 May 12. doi: 10.1007/s13365-021-00983-z.

Disability progression in multiple sclerosis is associated with plasma neuroactive steroid profile.

Cheng C, Gomez D, McCombe JA, Smyth P, Giuliani F, Blevins G, Baker GB, Power C*.  Neurol Sci. 2021 Apr 8. doi: 10.1007/s10072-021-05203-4

Intranasal anti-caspase-1 therapy preserves myelin and glucose metabolism in a model of progressive multiple sclerosis.

Saito LB, Fernandes JP, Smith MJ, Doan MAL, Branton WG, Schmitt LM, Wuest M, Monaco MC, Major EO, Wuest F, Power C* Glia 2021 Jan;69(1):216-229. PMID: 32882086

Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis.

McKenzie BA, Fernandes JR, Doan MAL, Schmitt L, Branton WG, Power C*, J Neuroinflammation 2020 Aug 29; 17(1):253. PMID: 32861242

Fiery cell death: pyroptosis in the central nervous system

 McKenzie BA, Dixit VM, Power C*. Trends Neurosci 2020 Jan; 43(1):55-73. PMID: 31843293

Machine learning models reveal neurocognitive impairment type and prevalence are associated with distinct variables in HIV/AIDS.

Tu W, Chen PA, Koenig N, Gomez D, Fujiwara E, Gill MJ, Kong L, Power C*. J Neurovirol 2020 Feb;26(1):41-51. PMID: 31520320