Dr. Vaibhav Patel

  1. What does the Translational Research Fellowship Award mean to you?
    • After completing my Ph.D. in Pharmacy (Pharmacology), I wanted to do fellowship in more clinically relevant and translational research. I joined Dr. Gavin Oudit's lab and started working on role of ACE2 in diabetic cardiovascular complications and we published it in Circulation Research, with an accompanying Editorial. The Translational Research Fellowship Award is the recognition of the best translational work published during the preceding year at Department of Medicine and, I am more than happy to get this award. This award motivates me to keep up with my translational research and to continue to be productive.
  2. Tell us a little about your research project (in 100 words or less).
    • Cardiovascular complications are the leading cause of death in patient with diabetes and role of renin-angiotensin system (RAS) has been implicated in the progression of diabetic cardiomyopathy. ACE2, discovered in 2000, is a new member of RAS family which is known to negatively regulate the RAS. We found that the type-1 diabetic mice lacking ACE2 had more diabetic cardiovascular complications and we concluded that recombinant human ACE2 could be a new class of drug which may be used to curtail the progression of diabetic cardiovascular complications.
  3. What are the plans for the duration of your studies?
    • During my training, I am planning to study the role of ACE2 in a mouse model of type-2 diabetes and to study how ACE2 is altered in patients with diabetes. We are also studying other targets playing crucial role in the pathophysiology of heart failure.
  4. What are your career goals?
    • I am very fortunate to receive the mentorship by Dr. Gavin Oudit. After being trained by a mentor like him, my career goal is to be a scientist and mentor at a graduate-degree granting institute and contribute to academic translational research.