MSc in Medicine - Translational Medicine Courses

MED 602–608 are courses offered to graduate students, teaching the principles of Translational Medicine, i.e. the process that brings a molecular discovery to actual patients and populations.

  • MED 602 Principles in Translational Medicine – Chronic Diseases
  • MED 604 Principles in Translational Medicine – Vascular Medicine
  • MED 606 Principles of Translational Medicine – Inflammatory Infectious Diseases; and 
  • MED 608 Principles in Translational Medicine – Metabolism

Overview

Our graduates will be able to:

  • identify and effectively navigate through the regulatory and quality control steps from bench to bedside, including emerging ethics issues in both animal and clinical research.
  • display skills and attitudes required for collaboration within multidisciplinary professional groups.
  • analyze and use modern statistical methods commonly used in both basic and clinical research.
  • determine the relative financial and social cost implications of new therapies from basic science to health policies and succeed in team grant writing as well as several forms of modern fundraising.
  • design basic science experiments with a specific therapy in mind and execute animal experiments in a manner that will optimize their translational potential to early phase human clinical trials.
  • conceive and design early-phase or outcomes clinical trials and studies in a manner that efficiently uses the knowledge obtained from animal studies and facilitates translation into clinical practice and policies.
  • master the general principles of molecular biology and genetics required to better design and execute health policies and select the most promising preclinical findings for advancement into the Personalized Medicine corridor.

Outline of a Typical Session

Pre-session

All students will have access to and will be expected to read one or two provided reviews on the topic that will allow them to understand the basis of the clinical case discussed. In addition, these reviews will often offer some overview (without details) of the research challenges and future directions in the field. The student presenting will be expected to search the literature for support to the points he/she will present. Specific questions and tasks are given to the student for each session, as seen in the "weekly session scheduleattached. The student will also post the papers he/she will find most helpful in the program’s CLOUD, so all students could review or have access to them during the session. Students will interact with each other and with the presenting faculty member before (and after) the session as needed.

Session

Sessions will feature 2 speakers, one presenting faculty member and a student – 15 min each: The faculty member will typically summarize the essentials of the clinical case discussed. This is not done with the intention to teach clinical medicine but only in order to provide the real-life clinical perspective n which the discussion will be based. The, he/she will answer the questions as outlined, according to their expertise and background. Overall the emphasis will be on the description of the basic or clinical research in their field, preparing the grounds for the discussion that would follow, in which solutions will be discussed. The student will follow with a 15 minute presentation in response to the task that he/she has been given. As can be seen in the listed tasks, the emphasis is not on the collection of facts. Rather, the student will be expected to use creativity and apply common logic in order to respond to the tasks, which are based on the learning of skills in applied translational research. Often the tasks are based on hypothetical research platforms and questions and do not require previous knowledge of the field or extensive review of the subject. Broad concepts should be presented emphasizing on research rationale, originality and creativity and not known facts.

Discussion and Post-Session

The main objective of the discussion is to synthesize the information presented and discuss an optimal pathway that is needed in order to optimize translation from preclinical to the clinical stage, focusing on a continuum of the molecule-animal-patient-populations-health services model. For example: “How is preclinical research and clinical trial design need to be modified to promote translation, what kind of teams need to be put in place in order to achieve this”, etc. A student will be assigned for each session and, after the discussion, will be called to draft a 250 word abstract / “executive summary”, post it on the CLOUD, discussed in the discussion forum and finalized a week later. Eventually the program will have these executive summaries for all the diseases discussed with the potential for subsequent publication of the curriculum.

Evaluation

The following table summarizes how students will be evaluated for MED 602 – 608

 Class Participation Presentation   Final Examination
 30%  30% 40% 

*Note: The final examination will be an in-class open book exam. It will focus on research concepts learned during the sessions, rather than on disease-specific details.

Presentation points will be based upon the student’s in-class presentation(s). Students are evaluated on organization of material into a clear and concise presentation, response to questions and articulation of the major issues in the field (see participation criteria below).

Class participation will be based upon demonstration of the student’s insight into the issues facing researchers in the topic areas, including successes and challenges of performing research in that area:

  • "Successes" refer to recent major discoveries which have significantly changed thinking about the disease/field.
  • "Challenges" refer to methodologic, administrative or ethical issues which must be overcome in order to advance translation of findings from animal to human research or to health policies

All grades are reviewed by the Translational Medicine Steering Committee

Course Materials

Graduate students will access all materials (including the recommended reading as shown in the attached weekly sessions schedule) through eClass.

Challenge Evaluation

Graduate students must achieve a grade of at least a C+ (65-69%)

*Note: Evaluation procedures and information for graduate students can be found through the Office of the Registrar at: http://www.registrar.ualberta.ca/calendar/Regulations-and-Information/Academic-Regulation/23.4.html#23.4)

"Policy about course outlines can be found in §23.4(2) of the University Calendar".

"The University of Alberta is committed to the highest standards of academic integrity and honesty. Students are expected to be familiar with these standards regarding academic honesty and to uphold the policies of the University in this respect. Students are particularly urged to familiarize themselves with the provisions of the Code of Student Behaviour (online at www.governance.ualberta.ca) and avoid any behaviour which could potentially result in suspicions of cheating, plagiarism, misrepresentation of facts and/or participation in an offence. Academic dishonesty is a serious offence and can result in suspension or expulsion from the University."