Melanie Lacaria

Assistant Clinical Professor

Research areas: Clinical genetic diagnostics, cytogenetics, mechanisms of genomic rearrangements.


Selected Publications:

A rare case of pediatric lipoma with t(9;12)(p22;q14) and evidence of HMGA2-NFIB gene fusion.
Lacaria M, El Demellawy D, McGowan-Jordan J.
Cancer Genet. 2017 Oct; 216-217.

Expansion of the Clinical Phenotype of the Distal 10q26.3 Deletion Syndrome to Include Ataxia and Hyperemia of the Hands and Feet.
Lacaria M, Srour M, Michaud J, Doja A, Miller E, Schwartzentruber J, Majewski J, FORGE Canada Consortium, Boycott K.
Am J Med Genet A. 2017 Jun;173(6):1611-1619.

Enriched rearing improves behavioral responses of an animal model for CNV-based autistic-like traits.
Lacaria M, Spencer C, Gu W, Paylor R, Lupski JR.
Hum Mol Genet. 2012 May 15. PMID: 22492990.

A duplication CNV that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice and men.
Lacaria M, Saha P, Potocki L, Bi W, Yan J, Girirajan S, Burns B, Elsea S, Walz K, Chan L, Lupski JR, Gu W.
PLoS Genet. 2012 May;8(5):e1002713.

Frequency of nonallelic homologous recombination is correlated with length of homology: evidence that ectopic synapsis precedes ectopic crossing-over.
Liu P, Lacaria M, Zhang F, Withers M, Hastings PJ, Lupski JR.
Am J Hum Genet 2011 Oct 7: 89(4): 580-8.