I teach radiation physics in the Radiation Therapy Program.
Radio-Frequency Encoded Magnetic Resonance Imaging (MRI)
I am co-inventor of a novel MR imaging technology that eliminates the need for conventional imaging gradients. 'Gradient-free' imaging ('TRASE' - Transmit Array Spatial Encoding) is an entirely novel MRI approach which eliminates the traditional gradient coil system, eliminating bulk, cost and much complexity. This technology has the potential to substantially reduce the cost and increase the robustness of MRI. The work was featured in Nature 'Research Highlights' in September 2013.
MRI Techniques, Simulation and Image Formation
I have a long-standing interest in MRI data acquisition techniques ('pulse sequences') including the use of computer simulations. One example is a technique that I invented which retrospectively compensates for magnetic field shimming errors by combining signals from an array of detection coils.
MRI Systems and Technology
I have designed MRI control equipment (MRI consoles), two of which are currently in use running MRI research systems here in the Medical Physics division. Design of our own equipment allows us greater flexibility and scope for technological innovation than does the use of commercial systems.
Foundations of Quantum Mechanics
The topic of quantum foundations concerns efforts to find an 'interpretation' of quantum mechanics. Amongst physicists, there is remarkably little consensus on what quantum mechanics actually means, even though it is a tremendously successful and useful theory. The "Copenhagen Interpretation" of Niels Bohr is the traditional approach, but leaves much unsaid. With the development of quantum technologies, such as quantum computing and encryption, experiments are probing systems which may demand a more specific ontology. A better understanding of the causes of decoherence may be of great practical relevance for these technologies.
Real-time MRI in Radiotherapy
MRI offers superior tissue contrast and image quality than X-ray CT, but has only recently been integrated with radiotherapy treatment systems (see the linac-mr.ca website for more information). My research interest is in the MRI techniques needed for real-time control of external beam radiotherapy treatment to enable higher treatment accuracy in the presence of tumor motion.
Electronics, Magnetic Resonance Imaging, Medical Devices, Medical Imaging, Medical Physics, MRI, NMR, Nuclear Magnetic Resonance, Quantum Mechanics, Radiofrequency Coils, Radiofrequency Technology, Radiotherapy, radiotherapy mri, RF Coils, Software, Space Flight, Special Relativity, TRASE
Hongwei Sun (Ph.D. student)
Pallavi Bohidar (Ph.D. student)
Aaron Purchase (Ph.D. student)
"A cheaper, quieter MRI machine", Research Highlights, Nature 501, p.138-139 (12 Sept 2013)
H, AlZubaidi A, Purchase A, Sharp JC. A Geometrically-Decoupled, Twisted Solenoid Single-Axis Gradient Coil Set for TRASE (Magnetic Resonance in Medicine; MS# MRM-19-20161. Accepted August 2019.)
Bohidar P, Sun H, Sarty GE, Sharp JC. TRASE 1D Sequence Performance in Imperfect B1 Fields. Journal of Magnetic Resonance, 305 (2019) 77-88 https://doi.org/10.1016/j.jmr.2019.06.005
Aaron R. Purchase, Tadeusz Palasz, Hongwei Sun, Jonathan C. Sharp, Boguslaw Tomanek. A high duty-cycle, multi-channel, power amplifier for high-resolution radiofrequency encoded magnetic resonance imaging. Magnetic Resonance Materials in Physics, Biology and Medicine (In Press. First online 20th June 2019) https://doi.org/10.1007/s10334-019-00763-1
Mai K. Vo and Jonathan C. Sharp. Design, Development and Content Creation for an Open Education Physics Website for MRT Education. Journal of Medical Imaging and Radiation Sciences. Vol.50 (2019), pp.212-219. https://doi.org/10.1016/j.jmir.2019.03.180 (available online 17 April 2019, final form 5-June 2019).
Hongwei Sun, Stephanie Yong, Jonathan C. Sharp. The Twisted Solenoid RF Phase Gradient Transmit Coil for TRASE Imaging. Journal of Magnetic Resonance 299 (2019) 135–150. https://doi.org/10.1016/j.jmr.2018.12.015
Eric Der, Vyacheslav Volotovskyy, Hongwei Sun, Boguslaw Tomanek, Jonathan C. Sharp. Design of a high power PIN-diode controlled switchable RF transmit array for TRASE RF imaging. Concepts in Magnetic Resonance B, 48B(1), February 2018 e21365 First published: 07 June 2018. https://doi.org/10.1002/cmr.b.21365
Sharp JC. Symmetry of the Lorentz boost: the relativity of colocality and Lorentz time contraction. European Journal of Physics. 37(5): 055606. https://doi.org/10.1088/0143-0807/37/5/055606
Tomanek, B., Volotovskyy, V., Tyson, R., Yin, D., Sharp, J. and Blasiak, B. (2016), A quadrature volume RF coil for vertical B0 field open MRI systems. Concepts Magn Reson, 46B: 118–122. doi:10.1002/cmr.b.21327
Salajeghe S, Babyn P, Sharp JC, Sarty GE. Least squares reconstruction of non-linear RF phase encoded MR data. Magnetic Resonance Imaging. Sep. 34(7): 951-963. (2016) doi: 10.1016/j.mri.2016.04.010. Epub 2016 Apr 23.
Blasiak B, Volotovskyy V, Tyson R, Sharp JC, Tomanek B. (2016). A RF Breast Coil for 0.2T MRI. Concepts in Magnetic Resonance Part B. 46(1): 3-7. https://doi.org/10.1002/cmr.b.21316
Blasiak B, Landry J, Tyson R, Sharp JC, Iqbal U, Abulrob A, Rushford D, Matyas J, Ponjevic D, Sutherland GR, Wolfsberger S, Tomanek B. Molecular Susceptibility weighted imaging of the glioma rim in a mouse model. (J Neurosci Methods. 2014 Apr 15;226:132-8. doi: 10.1016/j.jneumeth.2014.01.034. Epub 2014 Feb 10)
Sharp JC, King SB, Deng Q, Volotovskyy V, Tomanek B. High-resolution MRI encoding using radiofrequency phase gradients, NMR in Biomedicine 26 (11) p.1602-1607 Nov 2013. First published: 06 September 2013 https://doi.org/10.1002/nbm.3023
Deng Q, King SB, Volotovskyy V, Tomanek B, Sharp JC. B1 Transmit Phase Gradient Coil for Single-Axis TRASE RF Encoding, Magn Reson Imaging (2013), http://dx.doi.org/10.1016/j.mri.2013.03.017
Zhu X, Tomanek B, Sharp JC. A Pixel is an Artifact: On the Necessity of Zero-filling in Fourier Imaging. Concepts in Magnetic Resonance Part A, Vol. 42A(2) 32–44 (2013) https://doi.org/10.1002/cmr.a.21256
Sharp JC & King SB. MRI using Radio-Frequency Magnetic Field Phase Gradients. Magn. Reson. Med. 63:151-161, (2010) doi: https://doi.org/10.1002/mrm.22188.
Sharp JC, Yin D, Bernhardt RH, Deng Q, Procca AE, Tyson RL, Lo K, Tomanek B. The integration of real and virtual magnetic resonance imaging experiments in a single instrument. Rev. Sci. Instrum. 2009 Sep; 80(9):093709 doi: https://doi.org/10.1063/1.3202410