Dr. Laura M. Schmitt MD PhD FRCPC is a Royal College of Physicians and Surgeons of Canada trained Neuropathologist. As a Specialist in Neuropathology, Dr. Schmitt engages with both national and international Neuropathology societies including the Canadian Association of Neuropathologists, American Association of Neuropathologists as well as the Euro-CNS. Locally, she is a member of the Neuroscience and Mental Health Institute at the University of Alberta and a member of the Alberta MS Network.
Dr. Schmitt has always had an interest in Neuroscience and completed her Honours Bachelor's Degree in Neuroscience and Medical Degree at the University of Alberta during which time she was involved with clinical and basic science research in the field of cerebral ischemia and hemorrhagic stroke. Following her medical degree, she started residency training in Neuropathology at the University of Calgary during which time she took a leave of absence to complete her PhD in Neuroimmunology (Multiple sclerosis) at the University of Saarland, Germany. She returned to Calgary to finish her Specialty training in Neuropathology which she finished in 2017. Since coming to the University of Alberta, she has rejuvenated Neuropathology education and been involved with multiple collaborative research projects with her clinical colleagues.
As the Director for Neuropathology Education, I have a strong, vested interest in medical education and seek to instill a love of the Neurosciences and Neuropathology in all of my trainees.
Educational activities include:
1.) Post-Graduate Medical Education: resident rotations for Adult Neurology, Neurosurgery, Pediatric Neurology, Anatomical and General Pathology and elective residents/fellows (by request)
2.) Undergraduate Medical Education: local and visiting medical student electives, Neurology block
3.) University Courses: MLSCI250, LABMP593, LABMP400/500
- Hippocampal sclerosis and in vivo imaging modalities
- Spectrum of epilepsy-related lesions
2.) Multiple Sclerosis
- Inflammatory demyelination prevention/treatment
epilepsy, multiple sclerosis, neuroinflammation, stroke
Neuropathology Specialty Group: Dr. Frank van Landeghem, Dr. Sumit Das, Dr. Atilano Lacson, Dr. Harry Vinters
Steve TA, Gargula J, Misaghi E, Nowacki TA, Schmitt LM, Matt Wheatley B, Gross DW, Hippocampal subfield measurement and ILAE hippocampal sclerosis subtype classification with in vivo 4.7 tesla MRI, Epilepsy Research (2020)
Walter S., Gulbins E., Halmer R., Jahromi N., Becker K., Schottek A., Blatti C., Davies L., Schnoeder L., Bertsch T., Engelhardt B., Fassbender K . Pharmacological Inhibition of Acid Sphingomyelinase Ameliorates Experimental Autoimmune Encephalomyelitis. Neurosignals 2019;27(S1):20-31
Treit, S., Little, G., Steve, T., Nowacki, T., Schmitt, L., Wheatley, B., Beaulieu, C., & Gross, D. (2019). Regional hippocampal diffusion abnormalities associated with subfield‐specific pathology in temporal lobe epilepsy. Epilepsia Open, 4(4), 544–554.
Chan E, Lauzon J, Resch L, Argiropoulos B, Schmitt L, Chadha R. Atypical Prenatal Ultrasound Presentation and Neuropathological Findings in a Neonate with Alpha Thalassemia Major: A Case Report. Pediatric and Developmental Pathology, 22(2), 166–170, 2019.
Chan V, Marro A, Findlay JM, Schmitt LM, Das S. A Systematic Review of Atypical Teratoid Rhabdoid Tumor in Adults. Frontiers in Oncology. 8:567, 2018.
Becker, K., A., Halmer, R., Davies, L., Henry, B., D, Ziobro-Henry, R., Decker, Y., Liu, Y., Gulbins, E., Fassbender, K., Walter, S. Blockade of Experimental Multiple Sclerosis by Inhibition of the Acid Sphingomyelinase/Ceramide System. Neurosignals. 25: 88-97, 2017.
Halmer, R., Davies, L., Liu, Y., Faßbender, K., Walter, S. The Innate Immune Receptor CD14 Mediates Lymphocyte Migration in EAE. Cell Physiol Biochem. 37(1): 269-75, 2015.
Gries, M., Davies, L., Liu, Y., Bachhuber, A., Spiegel, J., Dillmann, U., Hartmann, T., Faßbender, K., Walter, S. Response of Toll-like receptors in experimental Guillain-Barré syndrome: A kinetic analysis. Neuroscience Letters. 518: 154-160, 2012.
Manawadu, D., Davies, L.M., Salam, A., Shuaib, A., Jeerakathil, T.J. A telephone interview to diagnose transient ischemic attack is feasible and sensitive. Abstract. Presented at the American Academy of Neurology in Chicago (2008) and European Stroke Conference in Nice (2008).
MacLellan, C. L., Davies, L., Fingas, M., Colbourne, F. The influence of hypothermia on outcome after intracerebral hemorrhage in rats. Stroke. 37: 1266-1270, 2006.
Davies, L., MacLellan, C., Corbett, D., Colbourne, F. Postischemic diazepam does not reduce hippocampal CA1 injury and does not improve hypothermic neuroprotection. Brain Research. 1013: 223-229, 2004.
Although I practice "General Neuropathology" in that I diagnose the broad-spectrum of Neurological diseases, my special clinical interests include autopsy/forensic Neuropathology, epilepsy, multiple sclerosis, stroke and neuromuscular disease.