Faculty Members

Dr. Rachel Wevrick

Professor
Department of Medical Genetics
    Contact details are for academic matters only.

About Me

TRAINING

PhD: Department of Molecular and Medical Genetics, University of Toronto, 1987-1991

Post-doctoral fellow: Department of Genetics, The Hospital for Sick Children Research Institute, 1992

Post-doctoral fellow: Howard Hughes Medical Institute, Stanford University School of Medicine, 1993-1995

Professor: Department of Medical Genetics, University of Alberta, 1996-present

 

ADVISORY BOARDS

Member: Womens and Chhildren’s Health Research Institute, University of Alberta

Member, Neurosciences and Mental Health Research Institute, University of Alberta

Scientific Advisor to the Board, FPWR-Canada

Member of the Scientific Advisory Board, Prader-Willi Syndrome Association (USA)

Member of the Scientific Board of Directors, Foundation for Prader-Willi Research (USA) 

Member of the Foundation for Prader-Willi Research Preclinical Animal Models Network

Member of the Foundation for Prader-Willi Research Cellular Network Program

 

CURRENT FUNDING

CIHR Operating grant “Genetic and functional analysis of a mouse model of pediatric obesity”

NSERC Discovery grant “Exploration of a melanoma antigen (MAGE)-E3 ubiquitin ligase circuit governing circadian rhythm”

Women and Children’s Health Research Institute “Genetic Analysis of Children with a Dual Diagnosis of Tourette Syndrome and Autism Spectrum Disorder”

Foundation for Prader-Willi Research “Cellular role of MAGEL2 in Prader-Willi and Schaaf-Yang syndromes”

Simons Foundation Pilot Project Grant SFARI Award “Studies of MAGEL2, an autism and Prader-Willi syndrome candidate gene”



Research

Research Areas:

Genes and development, obesity, psychiatric disorders; mouse models for Prader-Willi syndrome; molecular basis of human genetic disorders.

Current research:

Research in the Wevrick laboratory focuses on genetic disorders that affect human development. We have specific interests in pediatric obesity, developmental delay, and also study developmental aspects of gene regulation. We identified genes that are inactivated in Prader-Willi syndrome, a sporadic chromosomal disorder that causes neonatal hypotonia, developmental delay, compulsive overeating leading to obesity, and abnormalities of sleep and respiration. We are currently studying the roles of these genes in the normal development of the nervous, muscular, and endocrine systems. Two genes, necdin and MAGEL2, have specific roles in growth and differentiation. We are using mouse models to evaluate the normal roles of these proteins and the effect of their loss in Prader-Willi syndrome.

If you are interested in a graduate student or postdoctoral position in my laboratory, please contact me at rwevrick@ualberta.ca, and include your cv.

Sources of Funding:

Projects in the Wevrick laboratory are funded by the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council, the Foundation for Prader-Willi Research, the Simons Foundation for Autism Research and the Women and Children's Health Research Institute. We also gratefully acknowledge funding from the Prader-Willi Syndrome Association of Alberta, the  Foundation for Prader-Willi Research (Canada) and One SMALL Step.

Donations in support of Prader-Willi Syndrome research in the Wevrick laboratory can be made by contacting the Office of Advancement at 1-888-799-9899, emailing giving@ualberta.ca, or by visiting "www.giving.ualberta.ca/ContactUs.aspx"


Research Keywords

neurodevelopmental disorders, Prader-WIlli syndrome, Schaaf-Yang syndrome, brain function and development, preclinical research , cellular and animal models of disease