Faculty Members

Dr. Constantine Karvellas

Associate Professor

Department of Medicine

Division of Gastroenterology
    Contact details are for academic matters only.

About Me

Dr. Constantine (Dean) Karvellas is an Associate Professor of Medicine (Critical Care Medicine and Gastroenterology/Hepatology) at the University of Alberta and an Adjunct Professor in the School of Public Health Sciences. He has been an attending intensivist in the E. Garner King General Systems Intensive Care Unit since 2009 and is involved with the Liver Transplant program as a Hepatologist. Dr. Karvellas is the only Canadian co-investigator in the NIH-funded United States Acute Liver Failure study group (US ALFSG). He is also a member of the Society of Critical Care Medicine (SCCM) Liver management task force. Dr. Karvellas’ publications reflect his interests in acute liver failure (ALF), acute on chronic liver failure (ACLF), liver transplantation and extracorporeal liver support.


Peer-Reviewed: Original Research

  • Poonja Z, Brisebois A, Veldhuyzen van Zanten S, Tandon P, Meeberg G, Karvellas C. Patients with Cirrhosis and Denied Liver Transplants Rarely Receive Adequate Palliative Care or Appropriate Management. Clin Gastroenterol Hepatol. 2014 Apr; 12(4): 692-8. 
  • Karvellas CJ, Fix OK, Battenhouse H, Durkalski V, Sanders C, Lee WM; for the U.S. Acute Liver Failure Study Group. Outcomes and Complications of Intracranial Pressure Monitoring in Acute Liver Failure: A Retrospective Cohort Study. Crit Care Med. 2014 May; 42(5): 1157-1167. 
  • Karvellas CJ, Cavazos J, Battenhouse H, Durkalski V, Balko J, Sanders C, Lee WM; US Acute Liver Failure Study Group. Effects of Antimicrobial Prophylaxis and Blood Stream Infections in Patients with Acute Liver Failure: a Retrospective Cohort Study. Clin Gastroenterol Hepatol. 2014 Nov;12(11):1942-9. 
  • Cardoso FS, Karvellas CJ, Kneteman NM, Meeberg G, Fidalgo P, Bagshaw SM. Respiratory rate at ICU discharge after liver transplant is an independent risk factor for ICU readmission within the same hospital stay: a nested case-control study. J Crit Care. 2014 Oct;29(5):791-6. 
  • Du Y, Karvellas CJ, Baracos VE, Williams DC and Khadaroo R. Sarcopenia is a Predictor of Outcomes in Very Elderly Patients Undergoing Emergency Surgery. Surgery. 2014 Sep;156(3):521-7.
  • Karvellas CJ, Stravitz RT, Battenhouse H, Lee WM, Schilsky ML; for the US Acute Liver Failure Study Group. Therapeutic hypothermia in acute liver failure: A multi-center retrospective cohort analysis. Liver Transpl. 2015 Jan; 21(1):4-12.
  • Kupper S, Karvellas CJ, Khadaroo R, Widder SQ. Increased health services use by severely obese patients undergoing emergency surgery: a retrospective cohort study. Can J Surg. 2015 Feb; 58(1):41-7. •Karvellas CJ, Abraldes JA, Arabi Y, Kumar A. Appropriate and timely antimicrobial therapy in cirrhotic patients with spontaneous bacterial peritonitis-associated septic shock: a retrospective cohort study. Aliment Pharmacol Ther. 2015 Apr;41(8):747-57. 
  • Speiser, J, Lee, WM, Karvellas CJ. Predicting outcome on admission and post-admission for acetaminophen-induced acute liver failure using classification and regression tree models. PloS One. 2015 Apr 17;10(4):e0122929. 
  • Cardoso FS, Karvellas CJ, Kneteman NM, Meeberg G, Fidalgo P, Bagshaw SM. Postoperative Resource Utilization and Survival among Liver Transplant Recipients with MELD greater or equal to 40: A Retrospective Cohort Study. Can J Gastroenterol Hepatol. 2015 May;29(4):185-91. 
  • Cardoso FS, Bagshaw SM, Abraldes JG, Kneteman NM, Meeberg G, Fidalgo P, Bagshaw SM, Karvellas CJ. Comorbidities have a limited impact on post-transplant survival in carefully selected cirrhotic patients: a population-based cohort study. Ann Hepatol. 2015;14(4):505-514. 
  • Kaur G, Leslie EM, Tillman H, Lee WM, Swanlund DP, Karvellas CJ. Detection of Ophthalmic Acid in Serum from Acetaminophen-induced Acute Liver Failure Patients is More Frequent in Non-survivors. PLoS One. 2015 Sep 25;10(9):e0139299. 
  • Nadim MK, Durand F, Kellum JA, Levitsky J, O'Leary JG, Karvellas CJ, Bajaj JS, Davenport A, Jalan R, Angeli P, Caldwell SH, Fernández J, Francoz C, Garcia-Tsao G, Ginès P, Ison MG, Kramer DJ, Mehta RL, Moreau R, Mulligan D, Olson JC, Pomfret EA, Senzolo M, Steadman RH, Subramanian RM, Vincent JL, Genyk YS. Management of the Critically Ill Patient with Cirrhosis: A Multidisciplinary Perspective. Journal of Hepatology. J Hepatol. 2016 Mar; 64(3):717-35. 
  • Karvellas CJ, Tillman H, Leung AA, Lee WM, Schilsky ML, Hameed B, Todd Stravitz R, McGuire BM, Fix OK; United States Acute Liver Failure Study Group. Acute Liver Injury and Acute Liver Failure from Mushroom Poisoning in North America. Liver Int. 2016 Feb 2{Epub ahead of print]. 
  • Reuben A, Tillman H, Fontana R, Davern T, Mcguire B, Stravitz RT, Durkalski V, Larson A, Liou I, Fix OK, Schilsky ML, McCashland T, Hay E, Murray N, Shaikh O, Ganger D, Zaman A, Han SH, Chung R, Smith A, Brown RS, Crippin J, Harrison J, Koch DG, Munoz S, Reddy R, Rossaro L, Satyanarayana R, Hassenein T, Hanje AJ, Olson J, Subramanian R, Karvellas CJ, Hameed B, Sherker A, Robuck P, Lee WM. OUTCOMES IN ADULTS WITH ACUTE LIVER FAILURE (ALF) FROM 1998 TO 2013: AN OBSERVATIONAL COHORT STUDY. Ann Intern Med 2016 (in press). 

Peer reviewed: Invited Reviews

  • Karvellas CJ, Bagshaw SM. Advances in management and prognostication in critically ill cirrhotic patients. Curr Opin Crit Care. 2014 Apr; 20(2): 210-7. 
  • Pai R, Karvellas CJ. Is Palliative Care Appropriate in the Liver Transplant Candidate? Clin Liver Dis. 2015 Vol 6(1):24–26. 
  • Karvellas CJ, Durand F, Nadim MN. Acute kidney injury in Cirrhosis. Crit Care Clin. 2015. 2015 Oct;31(4):737-50. 
  • Karvellas CJ, Subramanian R.Current Evidence for Extracorporeal Liver Support Systems in Acute and Acute on Chronic Liver Failure. Crit Care Clin 2016. (in press) 

Research Keywords

acetaminophen toxicity, Acute Liver Failure, Acute on chronic liver failure, Albumin Dialysis, biomarkers, Cirrhosis, Critical Illness, critically ill, fatty acid binding protein, Hepatic Encephalopathy, intracranial hypertension, Intractable Pruritus, liver transplant, mass spectrometry, Molecular Adsorbent Recirculating System, palliative care, rehabilitation, Total Parenteral Nutrition