Faculty

Daniel Graf

Associate Professor

Department of Dentistry

Division of Foundational Sciences

About Me

Daniel Graf was born in Lucerne, Switzerland and graduated in Biology from the Swiss Federal School of Technology Zurich. He did his PhD and post-doctoral studies at the Robert Koch-Institute, Berlin, the MRC Clinical Sciences Centre, London, and Biomedical Sciences Research Centre ‘Al. Fleming’, Athens, Greece. He led research groups at the BSRC ‘Al. Fleming’ Athens and the Institute of Oral Biology, University of Zurich. Trained in molecular and experimental Immunology, Developmental Biology, and Mouse Genetics he has been focusing on the molecular analysis of Bone Morphogenetic Protein (BMP) signaling through functional genomics approaches for the last decade. He made several contributions to our understanding of BMP function in tissues other than bone, including the immune system, the brain, and more recently craniofacial tissues. 

Research

The head is a very complicated structure and home to many important organs. Craniofacial tissues are affected in three out of four human congenital birth defects, but in most cases the underlying genetic variation remains unknown. We seek to understand how orofacial structures develop and what goes wrong in the case of malformations.

Orofacial structures develop through reciprocal interactions of neural crest and epithelial cells. Central to these interactions is the reiterated use of only a few conserved signaling networks, amongst them Bone Morphogenetic Protein signaling. Bone Morphogenetic Proteins (BMPs) are evolutionary highly conserved molecules that regulate the development of most embryonic tissues. These molecules are also involved in the homeostasis and repair of most adult tissues.

By altering BMP signalling in vivo we study their specific involvement during the development of orofacial structures, which helps us to understand how altered BMP signalling results in orofacial malformations. Untangling the molecular and cellular interactions will not only give us a better understanding of the developmental processes in question, but will also facilitate novel approaches for tissue repair

Research Keywords

Amelogenesis Imperfecta, Bmp signaling, bone development, Bone Morphogenetic Proteins, Cleft Palate, comparative gene expression analysis (incl. NGS), craniofacial malformation, Developmental Biology, Differential gene expression, Disease Model, Embryology, ex vivo explant cultures, Extracellular matrix, Eye physiology, Gene expression, Hard tissue histology, Lineage Tracing, morphometrics, Mouse Genetics, Mouse transgenesis, Periodontal disease model, Periodontal tissue, Pierre Robin Sequence, Retina, RNA in situ hybridization, Transplantation under kidney capsule