Welcome to CSAR, the Centre for the Studies of Asphyxia and Resuscitation, a world-leading program that is unique in Canada.
CSAR’s research focus is to 1) understand basic respiratory, cardiovascular, neurological and metabolic changes during fetal to neonatal transition and 2) improve diagnoses, mitigate risk and improve survival and quality of life for newborns. CSAR is a leading training and innovation centre in neonatal asphyxia and resuscitation research, and a leader in research translation to policy. CSAR is developing new research directions, influences guideline development and policy statements for national and international health communities.
CSAR integrates an excellent research team with a focus on asphyxia and resuscitation, and on follow-up for outcomes (e.g. chronic lung disease and neurodevelopmental delays). CSAR studies asphyxia and resuscitation ranging from basic to clinical research. In the delivery rooms CSAR uses a unique recording system, which continuously measures respiratory, cardiovascular, neurological and metabolic changes during fetal to neonatal transition.
In 2014 Dr. Georg Schmölzer (Director of CSAR) received the inaugural Heart and Stroke Foundation Professorship in Neonatal Resuscitation to improve the care for newborn infants in Canada.
1) RETAIN: A Board Game That Improves Neonatal Resuscitation Knowledge Retention. Maria Cutumisu, Siddhi D. Patel, Matthew R. G. Brown, Caroline Fray, Patrick von Hauff, Thomas Jeffery and Georg M. Schmölzer. Front. Pediatr., 31 January 2019 | https://doi.org/10.3389/fped.2019.00013
2) The RETAIN educational platform (https://www.playretain.com)
Globally, 15 million newborns are born prematurely and 20% of them require support at birth; annually, ~1 million of these will die due to birth asphyxia. A significant proportion of these critically ill newborns survive with chronic lung disease or neurodevelopmental disabilities. This puts a heavy burden on health resources, as these infants require frequent hospital re-admission. Refining resuscitation techniques to decrease long-term complications has potential to improve quality of life for newborns and their families.
CSAR's focus is to 1) understand basic respiratory, cardiovascular and neurological changes during the fetal to neonatal transition and 2) improve diagnoses, mitigate risk and improve survival and quality of life for newborns. Improving neonatal outcomes requires specialized, interdisciplinary centres such as CSAR, which combine basic, clinical and translational research.
Current Reserach Focus include:
1) RETAIN to teach neonatal Resuscitation
2) Pulseless electrical activity in newborns
3) Neonatal Chest Compression combining high airway pressures and chest compression
4) Pediatric Chest Compression combining high airway pressures and chest compression
5) Clinical trials
CSAR - Research
Asphyxia, Chest Compression, Chronic Lung Disease, Cognitive Task Analysis, Delivery Room, Eye-tracking, Human Factors; Patient Safety, Infants, Neonatal Hypoxic Ischemic Encephalopathy, Neonatal Resuscitation, Newborns, Respiratory Distress Syndrome, Resuscitation, Serious Games, Surfactant
CSAR integrates an excellent research team with a wide range of interests including Basic Science, Simulation Research, Global Health, Delivery Room Research, and Translational Research (CSAR - Staff).
CSAR is proud to train the next generation of researchers. CSAR is a training centre for students from around the world. Recent students have been visiting CSAR from Canada, Japan, India, Norway, Germany, Italy, Ireland, and Austria (CSAR - Students)
1) Schmölzer GM, O'Reilly M, LaBossiere J, Lee TF, Cowan S, Qin S, Bigam DL, Cheung PY.Cardiopulmonary resuscitation with chest compressions during sustained inflations: A new technique of Neonatal Resuscitation that improves recovery and survival in a neonatal porcine model.Circulation 2013;128:2495-50.
2) Schmölzer GM, Kumar M, Pichler G, Aziz K, O’Reilly M, Cheung PY. Non-invasive versus Invasive respiratory support in preterm infants in the delivery room: A systematic review and meta-analysis. BMJ 2013;347:f5980.
3) Kirpalani H, Ratcliffe SJ, Keszler M, Davis PG, Foglia EE, Te Pas A, Fernando M, Chaudhary A, Localio R, van Kaam AH, Onland W, Owen LS, Schmölzer GM, Katheria A, Hummler H, Lista G, Abbasi S, Klotz D, Simma B, Nadkarni V, Poulain FR, Donn SM, Kim HS, Park WS, Cadet C, Kong JY, Smith A, Guillen U, Liley HG, Hopper AO, Tamura M; SAIL Site Investigators. Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants: The SAIL Randomized Clinical Trial. JAMA. 2019 Mar 26;321(12):1165-1175. doi: 10.1001/jama.2019.1660.
4) Using exhaled CO2 to guide initial respiratory support at birth – a randomized controlled trial. Ngan AY, Cheung PY, Hudson-Mason A, Megan O’Reilly M, van Os S, Kumar K, Khalid Aziz K, Schmölzer GM. Arch Dis Child Fetal Neonatal Ed February 2017 Jun 8. pii: fetalneonatal-2016-312286
5) Cerebral Oxygen Saturation to Guide Oxygen Delivery in Preterm Neonates for the Immediate Transition after Birth: A 2-Center Randomized Controlled Pilot Feasibility Trial. Pichler G, Urlesberger B, Baik N, Schwaberger B, Binder-Heschl C, Avian A, Pansy J, Cheung PY, Schmölzer GM.J Pediatr. 2016;170:73-8.e1-4.
Publication of 2019:
1. An Opportunity for Cognitive Task Analysis in Neonatal Resuscitation. Zehnder EC, Law BHY, Schmölzer GM. Front Pediatr. 2019 Aug 27;7:356. doi: 10.3389/fped.2019.00356. eCollection 2019. Review.
2. Enhanced monitoring during neonatal resuscitation. Schmölzer GM, Morley CJ, Kamlin OCOF. Semin Perinatol. 2019 Aug 17:151177. doi: 10.1053/j.semperi.2019.08.006.
3. Novel technologies for heart rate assessment during neonatal resuscitation at birth - A systematic review. Johnson PA, Cheung PY, Lee TF, O'Reilly M, Schmölzer GM. Resuscitation. 2019 Jul 19. pii: S0300-9572(19)30539-8. doi: 10.1016/j.resuscitation.2019.07.018.
4. Serious games, a game changer in teaching neonatal resuscitation? A review. Ghoman SK, Patel SD, Cutumisu M, von Hauff P, Jeffery T, Brown MRG, Schmölzer GM. Arch Dis Child Fetal Neonatal Ed. 2019 Jun 29. pii: fetalneonatal-2019-317011. doi: 10.1136/archdischild-2019-317011
5. Review of Biomedical Applications of Contactless Imaging of Neonates Using Infrared Thermography and Beyond. AlZubaidi AK, Ethawi Y, Schmölzer GM, Sherif S, Narvey M, Seshia M. Methods Protoc. 2018 Oct 29;1(4). pii: E39. doi: 10.3390/mps1040039.
6. Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia. Solevåg AL, Schmölzer GM, Cheung PY. Free Radic Biol Med. 2019 Apr 27. pii: S0891-5849(18)32359-1. doi: 10.1016/j.freeradbiomed.2019.04.028.
7. Chest Compressions During Sustained Inflation During Cardiopulmonary Resuscitation in Newborn Infants Translating Evidence From Animal Studies to the Bedside. Schmölzer GM. JACC Basic Transl Sci. 2019 Feb 25;4(1):116-121. doi: 10.1016/j.jacbts.2018.12.004.
8. Pharmacological and non-pharmacological treatments for the Neonatal Abstinence Syndrome (NAS). Mangat AK, Schmölzer GM, Kraft WK. Semin Fetal Neonatal Med. 2019 Apr;24(2):133-141. doi: 10.1016/j.siny.2019.01.009.
9. Chest Compressions in the Delivery Room. Garcia-Hidalgo C, Schmölzer GM. Children (Basel). 2019 Jan 3;6(1). pii: E4. doi: 10.3390/children6010004. 10. Evidence for vasopressors during cardiopulmonary resuscitation in newborn infants. O'reilly M, Schmölzer GM. Minerva Pediatr. 2019 Apr;71(2):159-173. doi: 10.23736/S0026-4946.18.05452-X.
11. Reducing Brain Injury of Preterm Infants in the Delivery Room. Viaroli F, Cheung PY, O'Reilly M, Polglase GR, Pichler G, Schmölzer GM. Front Pediatr. 2018 Oct 16;6:290. doi: 10.3389/fped.2018.00290. eCollection 2018.
12. A Review of Non-Pharmacological Treatments for Pain Management in Newborn Infants. Mangat AK, Oei JL, Chen K, Quah-Smith I, Schmölzer GM. Children (Basel). 2018 Sep 20;5(10). pii: E130. doi: 10.3390/children5100130.
13. Monitoring heart rate in the delivery room. Dawson JA, Schmölzer GM, Wyllie J. Semin Fetal Neonatal Med. 2018 Oct;23(5):327-332. doi: 10.1016/j.siny.2018.07.001.
14. Ventilation Strategies during Neonatal Cardiopulmonary Resuscitation. Baik N, O'Reilly M, Fray C, van Os S, Cheung PY, Schmölzer GM. Front Pediatr. 2018 Feb 12;6:18. doi: 10.3389/fped.2018.00018. eCollection 2018.
15. Review of Routes to Administer Medication During Prolonged Neonatal Resuscitation. Wagner M, Olischar M, O'Reilly M, Goeral K, Berger A, Cheung PY, Schmölzer GM. Pediatr Crit Care Med. 2018 Apr;19(4):332-338. doi: 10.1097/PCC.0000000000001493.