About MeDr. Götte obtained his PhD degree in 1997 at the Max-Planck-Institute for Biochemistry in Martinsried, Germany. In 2000, following his postdoctoral training at the Lady Davis Institute for Medical Research - Jewish General Hospital in Montreal, he joined the faculty at McGill University in the Department of Microbiology & Immunology. In 2014, he accepted the position as Chair of the Medical Microbiology & Immunology Department at the University of Alberta in Edmonton.
!!! Currently Hiring Graduate Students !!!
Research in Dr. Götte's laboratory is focused on the study of viral replication, its inhibition and mechanisms associated with antimicrobial resistance (AMR). His interests cover a broad range of important human pathogens including RNA viruses with a high epidemic potential.
Ebola, Nipah, Lassa, RSV, Influenza, viral RNA polymerase, nuclease, antiviral drugs, mechanism of action, drug discovery, drug development, antimicrobial resistance
Currently hiring graduate students interested in biochemical virology and drug discovery:
1. Inhibition of RNA polymerases of viruses with high epidemic potential, e.g. Ebola.
2. Mechanisms associated with Antimicrobial Resistance (AMR).
Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus.
Tchesnokov EP, Raeisimakiani P, Ngure M, Marchant D, Götte M.
Sci Rep. 2018 Mar 5;8(1):3970. doi: 10.1038/s41598-018-22328-3.
Press release: https://www.sciencedaily.com/releases/2018/03/180307121834.htm
Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir.
Tchesnokov EP, Feng JY, Porter DP, Götte M.
Viruses. 2019 Apr 4;11(4). pii: E326. doi: 10.3390/v11040326.
Mechanism of action of GS-5734 against Ebola virus RNA-dependent RNA polymerase.
- Funding Source: Gilead Sciences Inc. Foster City, USA
- Year Granted: 2018
- Research Role: Principal Investigator