Academic Faculty

Zaugg

Michael Zaugg, MD, MBA, FRCPC

Professor (UAH)

Medicine & Dentistry

Anesthesiology and Pain Medicine

Dr Zaugg obtained his medical degree in 1989 at the Faculty of Medicine of the University of Zurich (Zurich, Switzerland) and completed his residency training first in Internal Medicine and subsequently in Anesthesiology at the University Hospital Zurich. In 1997, Dr Zaugg was clinical fellow in Anesthesiology at the Mount Sinai Medical Center (New York, USA). Afterwards, he completed a basic science fellowship in Cell Biology and Cardiovascular Physiology, at the State University of New York (New York, USA). In 1999, Dr Zaugg returned to Zurich, Switzerland where he conducted seminal research in his own laboratory at the University of Zurich, while working as senior clinician at the University Hospital Zurich. In 2008, he became Fellow of the Royal College of Physicians and Surgeons of Canada, Ottawa (Canada) and was appointed Full Professor of Anesthesiology & Pain Medicine at the University of Alberta, Edmonton (Canada). In 2011, he completed his Master of Business Administration (eMBA) at the Alberta School of Business in Edmonton (Financial Times Ranking: 48) where he specialized in health care management and hospital finance.

As an internationally recognized clinician scientist, Dr Zaugg leads his successful research group which specialized in proteomics, transcriptomics, genetics, and more recently in metabolomics. His projects also investigate mechanisms of organ protection including stem cell research. Dr Zaugg’s research has been consistently funded by the Swiss National Science Foundation, and he is currently supported by the Heart and Stroke Foundation of Canada and the Canadian Anesthesia Research Foundation (CARF). He was the recipient of the 2005 Frontiers in Anesthesia Research Award from the Anesthesia Research Society. In 2011, Dr Zaugg was honored with the Canadian Research Award in Pain and Regional Anesthesia.

Beside his research, Dr Zaugg is strongly engaged in teaching and education with a special interest in simulations in Anesthesiology. He is the PAC director and involved in Healthcare Management. Dr Zaugg has published extensively in peer-reviewed medical journals and he regularly delivers invited lectures at international meetings such as the American Society of Anesthesiologists Annual Meeting, the Canadian Anesthesiologists’ Meeting, the Euroanesthesia Meeting, and the International Anesthesia Research Society Annual Meeting.


Special Interests and Keywords

Research: Perioperative medicine, organ protection, anesthetic pharmacology, heart disease/metabolism, diabetes/metabolism, genomics, proteomics, metabolomics

Education: Patient simulation in anesthesiology education and training

Management in Healthcare: Human resources, quality management, case and project management, managed care, health care delivery, diagnosis-related groups

Publications

Editorial Views

  1. Zaugg M, Lucchinetti E. Remote Ischemic Preconditioning in Cardiac Surgery--Ineffective and Risky? N Engl J Med. 2015;373(15):1470-2. PMID: 26436209

Management and Healthcare

  1. Effective Leadership in Hospital Management: How a CEO Can Lead a Hospital Towards More "Competitiveness". The GZO Case in Switzerland.  OJICA Vol 3. No. 1 (2012).

Clinical Investigations

  1. Aguirre JA, Lucchinetti E, Clanachan AS, Plane F, Zaugg M. Unraveling Interactions Between Anesthetics and the Endothelium: Update and Novel Insights. Anesth Analg. 2016 Feb;122(2):330-48. PMID: 26797549
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  3. Zaugg M, Lucchinetti E, Behmanesh S, Clanachan AS. Anesthetic cardioprotection in clinical practice. From proof-of-concept to clinical applications. Curr Pharm Des 2014;20(36):5706-26. PMID: 24502570
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  5. Lucchinetti E, Bestmann L, Feng J, Freidank H, Clanachan AS, Finegan BA, Zaugg M. Remote Ischemic Preconditioning Applied during Isoflurane Inhalation Provides No Benefit to the Myocardium of Patients Undergoing On-pump Coronary Artery Bypass Graft Surgery: Lack of Synergy or Evidence of Antagonism in Cardioprotection? Anesthesiology 2012;116(2):296-310. PMID: 22222469
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  7. Zaugg M, Bestmann L, Wacker J, Lucchinetti E, Boltres A, Schulz C, Hersberger M, Kälin G, Furrer L, Hofer C, Blumenthal S, Müller A, Zollinger A, Spahn DR, Borgeat A. Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-controlled, multicenter trial with 1-year follow-up. Anesthesiology. 2007; 107(1):33-44. PMID: 17585213
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  9. Lucchinetti E, Hofer C, Bestmann L, Hersberger M, Feng J, Zhu M, Furrer L, Schaub MC, Tavakoli R, Genoni M, Zollinger A, Zaugg M. Gene regulatory control of myocardial energy metabolism predicts postoperative cardiac function in patients undergoing off-pump coronary artery bypass graft surgery: inhalational versus intravenous anesthetics. Anesthesiology. 2007;106(3):444-57. PMID: 17325502
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  11. Julier K, da Silva R, Garcia C, Bestmann L, Frascarolo P, Zollinger A, Chassot PG, Schmid ER, Turina MI, von Segesser LK, Pasch T, Spahn DR, Zaugg M. Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study. Anesthesiology. 2003 Jun;98(6):1315-27. PMID: 12766638
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Translational Investigations

  1. Lou PH, Lucchinetti E, Zhang L, Affolter A, Gandhi M, Zhakupova A, Hersberger M, Hornemann T, Clanachan AS, Zaugg M. Propofol (Diprivanâ) and Intralipidâ exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking. Anesth Analg 2015;120(2):329-40. PMID: 25437926

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  3. Lou PH, Lucchinetti E, Zhang L, Affolter A, Gandhi M, Hersberger M, Warren BE, Lemieux H, Sobhi HF, Clanachan AS, Zaugg M. Loss of Intralipidâ- but not sevoflurane-mediated cardioprotection in early type-2 diabetic hearts of fructose-fed rats: importance of ROS signaling. PLoS One 2014 Aug 15;9(8):e104971. PMID: 25127027
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  5. Lou PH, Lucchinetti E, Zhang L, Affolter A, Schaub MC, Gandhi M, Hersberger M, Warren BE, Lemieux H, Sobhi HF, Clanachan AS, Zaugg M. The mechanism of Intralipidâ-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases. PLoS One. 2014 Jan 30;9(1):e87205. PMID 24498043
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  7. Lucchinetti E, Awad AE, Rahman M, Feng J, Lou PH, Zhang L, Ionescu L, Lemieux H, Thébaud B, Zaugg M. Antiproliferative Effects of Local Anesthetics on Mesenchymal Stem Cells: Potential Implications for Tumor Spreading and Wound Healing. Anesthesiology. 2012; 116(4):841-56. PMID: 22343474
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  9. Zaugg M, Wang L, Zhang L, Lou PH, Lucchinetti E, Clanachan AS. Choice of Anesthetic Combination Determines Ca2+ Leak after Ischemia-Reperfusion Injury in the Working Rat Heart: Favorable versus Adverse Combinations. Anesthesiology. 2012; 116(3):648-57. PMID: 22293718
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  11. Wacker J, Lucchinetti E, Jamnicki M, Aguirre J, Härter L, Keel M, Zaugg M. Delayed inhibition of agonist-induced granulocyte-platelet aggregation after low-dose sevoflurane inhalation in humans. Anesth Analg. 2008;106(6):1749-58. PMID: 18499605
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  13. Lucchinetti E, Aguirre J, Feng J, Zhu M, Suter M, Spahn DR, Härter L, Zaugg M. Molecular evidence of late preconditioning after sevoflurane inhalation in healthy volunteers. Anesth Analg. 2007;105(3):629-40. PMID: 17717216
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  15. Lucchinetti E, Ambrosio S, Aguirre J, Herrmann P, Härter L, Keel M, Meier T, Zaugg M. Sevoflurane inhalation at sedative concentrations provides endothelial protection against ischemia-reperfusion injury in humans. Anesthesiology. 2007;106(2):262-8. PMID: 17264719
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Basic Science

  1. Raturi A, Gutiérrez T, Ortiz-Sandoval C, Ruangkittisakul A, Herrera-Cruz MS, Rockley JP, Gesson K, Ourdev D, Lou PH, Lucchinetti E, Tahbaz N, Zaugg M, Baksh S, Ballanyi K, Simmen T. TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux. J Cell Biol. 2016; 214(4):433-44. PMID: 27502484

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  3. Warren BE, Lou PH, Lucchinetti E, Zhang L, Clanachan AS, Affolter A, Hersberger M, Zaugg M, Lemieux H. Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat. Am J Physiol Endocrinol Metab 2014 Mar;306(6):E658-67. PMID: 24425766
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  5. Lou PH, Zhang L, Lucchinetti E, Heck M, Affolter A, Gandhi M, Kienesberger PC, Hersberger M, Clanachan AS, Zaugg M. Infarct-remodelled hearts with limited oxidative capacity boost fatty acid oxidation after conditioning against ischaemia/reperfusion injury. Cardiovasc Res. 2013;97(2):251-61. PMID: 23097573
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  7. Feng J, Zhu M, Schaub MC, Gehrig P, Roschitzki B, Lucchinetti E, Zaugg M. Phosphoproteome analysis of isoflurane-protected heart mitochondria: phosphorylation of adenine nucleotide translocator-1 on Tyr194 regulates mitochondrial function. Cardiovasc Res. 2008;80(1):20-9. PMID: 18558627
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  9. Feng J, Lucchinetti E, Fischer G, Zhu M, Zaugg K, Schaub MC, Zaugg M. Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1alpha and CREB. Cardiovasc Res. 2008 Apr 1;78(1):98-107. PMID: 18218685
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  11. Zhu M, Feng J, Lucchinetti E, Fischer G, Xu L, Pedrazzini T, Schaub MC, Zaugg M. Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway. Cardiovasc Res. 2006;72(1):152-62. PMID: 16901477
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  13. da Silva R, Lucchinetti E, Pasch T, Schaub MC, Zaugg M. Ischemic but not pharmacological preconditioning elicits a gene expression profile similar to unprotected myocardium. Physiol Genomics. 2004 Dec 15;20(1):117-30. PMID: 15494475
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  15. Zaugg M, Lucchinetti E, Spahn DR, Pasch T, Schaub MC. Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial K(ATP) channels via multiple signaling pathways. Anesthesiology. 2002;97(1):4-14. PMID: 12131097
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For a full list of publications, please click here