Member, Women's and Children's Health Research Institute
Academic Editor, PLOS One
My teaching responsibilities include contributions to the following team-taught courses:
PHYSL 210: Human Physiology
PHYSL214: Human Physiology II
PHYSL 407: Molecular and Cellular Physiology
BIOCH 455: Biochemistry of Lipids and Lipoproteins
NUTR 302: Fundamentals of Nutritional Biochemistry and Metabolism II
Vitamin A (retinoid) homeostasis in health and diseaseVitamin A is an essential dietary micronutrient that has important functions in maintaining a healthy body. One of the active metabolites of dietary vitamin A is retinoic acid, which signals through nuclear receptors to control the expression level of more than 500 genes. The large number of retinoic acid-target genes confers on it important roles in many cellular processes, including cell proliferation, differentiation and apoptosis. The overall goal of the Clugston laboratory is to better understand the importance of altered retinoic acid signaling in human health and disease.
The Clugston lab currently has three major research tracks, all centered around understanding different aspects of vitamin A’s metabolism and action. These tracks are: 1) basic vitamin A metabolism, 2) the role of altered vitamin A homeostasis in liver disease, and 3) the role of altered vitamin A signaling in the development of the mammalian diaphragm and its importance in the birth defect, congenital diaphragmatic hernia.
alcohol, biochemistry, developmental biology, diaphragm, lipids, liver, nutrition, physiology, vitamin A
Altered hepatic retinoid homeostasis in the initiation and progression of alcoholic liver disease
- Funding Source: Canadian Institutes of Health Research
- Year Granted: 2018
- Research Role: Principal Investigator