Faculty Members

Prof. Sambasivarao Damaraju

Professor
Department of Laboratory Medicine & Pathology
    Contact details are for academic matters only.

About Me

Education:

1979 MSc (Biochemistry, University of Hyderabad, India)

1985 PhD (Biochemistry, National Institute of Nutrition/Osmania University, India)

1986 Post Doctoral Research Associate, Department of Pharmacology, University of Tennessee, Memphis, TN, USA

1987-90 Post doctoral Fellow, Alberta Heritage Foundation for Medical Research, Department of Biochemistry, University of Alberta, Edmonton.

Research

1. Breast cancer genomics: Identification of germline polymorphisms (SNPs and CNVs) of diagnostic, prognostic and predictive value using genome wide association study paradigm

- Genome wide association studies (GWAS) for phenotypes of breast cancer susceptibility

- GWAS for chemotherapy induced adverse drug reactions

- GWAS for bone metastasis

- Next Generation Sequencing profiling of breast tumors for small non-coding RNAs (miRNAs, piRNAs, snoRNAs, snRNAs, tRNAs)

- Small non-coding RNAs as prognostic factors

- Investigations of germline DNA CNVs and expressions of genes embedded within CNVs in breast tissues for protein and non-protein coding genes

2. Cancer Cachexia Genomics 

- Genome wide association studies (GWAS) for cancer cachexia predisposition

- Genome wide transcriptomic studies (Next Generation Sequencing) from human skeletal muscle biopsies for mRNAs, small non-coding RNAs and long non-coding RNAs

- Association of SNPs associated with opioid metabolism and phenotypes of cancer pain


Research Keywords

biobank, biospecimen science, service, open source, breast cancer, association, genetic susceptibility, breast cancer, genomics, pharmacogenomics, Breast cancer, Outcomes, miRNA, Breast cancer, Pharmacogenetics and Genomics, SNP, cardiotoxicity, chemotherapy, database, genetic determinants, adverse drug reactions, Genomics,Cachexia,Polymorphisms,prognostic markers, miRNA profiling; breast cancer; prognostic markers, Muscle loss/Cachexia, Cancer, Biomarkers, Pharmacogenetics, dosing based on genotype