Rheumatological diseases span many disorders and are among the most prevalent in society, affecting people of all ages. While my practice includes all types of rheumatic disease, one area that I am particularly interested in is lupus, because it affects the whole person—physical, cognitive, emotional and social—and is so variable in how it affects people. My research aims to discover ways to diagnose lupus early in its development and to ensure all lupus patients receive consistent high-quality care so that the disease is optimally managed. In parallel, I continue to evaluate patients with inflammatory arthritis (including rheumatoid arthritis, psoriatic arthritis and spondyloarthritis), both for optimizing the best treatments and managing associated co-morbidities including cardiovascular disease and osteoporosis. The ONTRAAC program is a state-of-the-art clinical research program which aims to provide the best care of these patients while studying factors which impact how they do. My past close collaborations with dermatology have led to the ongoing treatment of patients with dermatomyositis, which has led to new collaborations with rheumatologists and neurologists across the country to study how to best personalize treatment for these complex patients with varying disease presentations. I have recently collaborated with VIGOUR (Drs. Padma Kaul and Anamaria Savu) to study the impact of rheumatic diseases on the pregnancy outcomes of women in Alberta.
Dr. Stephanie Keeling completed her master’s degree in experimental medicine studying inflammatory back pain in spondyloarthritis.
Leadership and Collaborations:
Dr. Keeling established the Lupus Clinical of Northern Alberta (LUNA) with conjoint clinics in Dermatology. She has also collaborated with Cardiology at the Mazankowski Heart Institute and conducted a Cardiovascular Risk Reduction Clinic for Inflammatory Rheumatic Diseases which has now evolved into the new ON-Traac (On Treating Rheumatoid Arthritis, Access to Care) program with co-director Steven Katz. This treat-to-target clinic for inflammatory arthritis includes co-morbidity management for osteoporosis and cardiovascular risk utilizing a shared care model with allied health professionals.
Dr. Keeling is a member of the Canadian Network of Improved Outcomes in SLE (CaNIOS), a Canada-wide group of rheumatologists collaborating to study Canadian SLE patients and the Lupus Clinical Investigation Network (LUCIN), a North American network of rheumatologists who are working to improve the lives of patients with lupus.
She is the principal investigator of GRADE-based recommendations for the diagnosis and management of lupus in Canada. She is a board member of the Canadian Rheumatology Association and the Canadian Network for Improved Outcomes in Systemic Lupus Erythematosus, and is a medical advisory and board member of the Alberta Arthritis Society.
Dr. Keeling teaches and supervises medical students, residents and fellows. She is part of a team that is developing a mobile app called the Dermatology Rheumatology Educational Tool for Autoimmune Manifestations (DREAM) Tool, which was a finalist in the Excellence in Education category at the 2018 SKINPACT awards.
Dr. Keeling is a clinical researcher who is the local principal investigator for several clinical trials for lupus. The Arthritis Society of Canada named the evidence-based, clinical practice guidelines for lupus care across Canada, developed by Canadian SLE (Systemic Lupus Erythematosus) working group led by Dr. Keeling, as one of the top ten research advances in 2018. She has published her research findings in such journals as The Journal of Rheumatology. She has also written articles about lupus for the public in on-line publications such as Personal Health News.
co-morbidities, dermatomyositis, guidelines, pregnancy, psoriatic arthritis, rheumatoid arthritis, systemic lupus erythematosus
Keeling SO, Mallon C, Russell A, Maksymowych W. Low-dose Infliximab in Ankylosing Spondylitis: Efficacy and Safety During a 4-year Follow-up of a Prospective Observational Inception Cohort. J Rheumatol 33(3): 558-61, 2006
Keeling SO, Landewe R, van der Heijde D, Bathon J et al. Testing of the preliminary OMERACT validation criteria for a biomarker to be regarded as reflecting structural damage endpoints in rheumatoig arthritis clinical trials: the example of C-reactive protein. J Rheumatol 2007 (Mar); 34(3): 623-633.
Keeling SO, Wolbink GJ. Measuring multiple etancercept levels in the breast milk of a nursing mother with RA. J Rheumatol 2010 (July); 37(7): 1551.Impact Factor: 3.85
Keeling SO, Teo M, Fung D. Lack of cardiovascular risk assessment of inflammatory arthritis and systemic lupus erythematosus patients at a tertiary care center. Clin Rheumatology, Oct 2011;30(10):1311-7.
Ye C, Sholter D, Martin L, Keeling SO. The successful switch of patients with rheumatoid arthritis developing anti-tumor necrosis factor (anti-TNF)-induced lupus to another TNFagent. J Rheumatol 2011;38(6): 1216.
Keeling SO, Majumdar SR, Conner-Spady B, Battie MC, Carroll LJ, Maksymowych WP. Preliminary validation of a self-reported screening questionnaire for inflammatory back pain. J Rheumatol 2012 Feb 15 [E pub].
Keeling SO, Bissonauth A, Bernatsky S, Vandermeer B, Fortin PR, Gladman DD, Peschken C, Urowitz MB. Practice variations in the diagnosis, monitoring and treatment of systemic lupus erythematosus in Canada. J Rheumatol. 2018 Oct;45(10):1440-1447.
Keeling SO, Vandermeer B, Medina J, Chatterley T, Nevskaya T, Pope J, Alaburubalnabi Z, Bissonauth A, Touma Z. Measuring disease activity and damage with validated metrics: A systematic review on mortality and damage in systemic lupus erythematosus. J Rheumatol. 2018 Oct; 45(10):1448-1461.
Keeling SO, Alabdurubalnabi Z, Avina-Zubieta A, Barr S, Bergeron L, Bernatsky S, BourreTessier J, Clarke A, Baril-Dionne A, Dutz J, Ensworth S, Fifi-Mah A, Fortin PR, Gladman DD, Haaland D, Hanly JG, Hiraki LT, Hussein S, Legault K, Levy D, Lim L, Matsos M, McDonald EG, Medina-Rosas J, Pardo Pardi J, Peschken C, Pineau C, Pope J, Rader T, Reynolds J, Silverman E, Tselios K, Suitner M, Urowitz M, Touma Z, Vinet E, Santesso N. Canadian rheumatology association recommendations for the assessment and monitoring of systemic lupus erythematosus. J Rheumatol. 2018 Oct;45(10):1426-1439.
Dr. Keeling cares for patients as part of the Alberta Rheumatology unit at the Kaye Edmonton Clinic. In addition to the LUNA and ONTRAAC clinics, her rheumatology practice includes a large population of patients with dermatomyositis and spondyloarthritis and newer medications for these complex diseases.