The objective of the Fu laboratory is to better understand the molecular mechanisms underlying ovarian tumorigenesis, with a particular interest in the role of Notch signaling
pathway in ovarian cancer development and progression.
Ovarian cancer is the fifth leading cause of cancer deaths in women and the leading cause of gynecologic cancer-related death. The high mortality is due to the lack of effective methods for early detection of ovarian cancer. Despite advances in surgical techniques and chemotherapy regimens, relapse will occur in patients with advanced ovarian cancer. Patients become less responsive to chemotherapy with each subsequent relapse due to the development of drug resistance. Thus there is an urgent need to understand the molecular pathogenesis for
this heterogeneous disease and to identify potential signaling
pathways as therapeutic targets.
determines cell fate by regulating multiple processes such as differentiation, proliferation and apoptosis. Notch signaling
pathway has been associated with human cancers and proposed as potential
therapeutic target for several types of cancer. We will utilize tissue culture, molecular and cell biology approaches as well as mouse models to investigate whether activation of Notch signaling
plays a role in ovarian cancer development and progression,
and to identify the underlying molecular mechanisms.
The undergoing projects include 1) determining the role of Notch activation in ovarian cancer using in vitro and in vivo models, 2) identifying downstream effectors of Notch signaling
in ovarian cancer cells, and 3) studying how Notch interacts with other signaling
pathways in ovarian cancer. We hope that our research can lead to a better treatment for ovarian cancer in the future.
Cancer stem cells, Chemoresistance, Gene regulation, GUCY1B3, Nitric oxide, Notch pathway, Ovarian cancer, Signaling pathway, Soluble guanylyl cyclase