Faculty Members

Dr. Yangxin Fu

Associate Professor

Department of Oncology

Division of Experimental Oncology
    Contact details are for academic matters only.

About Me

Dr. YangXin Fu is currently appointed as Associate Professor in the Division of Experimental Oncology in the Faculty of Medicine and Dentistry.


Teaching

Oncology 320, Oncology 425, and Discovery Learning

Research

Our group has two main areas of interest: (1) Molecular mechanisms governing the tumorigenic phenotypes in ovarian cancer (signaling pathways and gene regulation) and (2) the impact of rRNA methylations on mRNA translation and the tumorigenic phenotypes in glioblastoma.

Project 1: To determine the molecular mechanisms governing the tumorigenic phenotypes in ovarian cancer. Current therapeutic regimens against advanced ovarian cancer are ineffective due to recurrent therapy resistant disease, driven at least in part by tumor heterogeneity. There is an urgent need to determine the molecular mechanisms by which the tumorigenic phenotypes are regulated, which will help identify potential novel therapeutic targets to treat ovarian cancer. This project is to study transcriptional regulation of the genes that are critical for cancer stem cells, proliferation, and metastasis in ovarian cancer. High throughput approaches (RNA-sequencing and ChIP-sequencing), as well as, in vitro and in vivo models are used to tackle this question.

Project 2: To determine the functional impact of rRNA methylations on mRNA translation and the tumorigenic phenotypes in glioblastoma. Glioblastoma is the most common and aggressive malignant primary brain tumor. The median survival of adults with glioblastoma is about 14.6 months even with aggressive surgical resection, radiation and chemotherapy. We need to better understand the molecular mechanisms underlying the initiation and progression of glioblastoma to develop novel therapeutics. Cancer cells have unique (specialized) and heterogeneous ribosomes that favors translation of subsets of mRNA associated with tumor initiation and/or progression. The objective of this project is to determine how rRNA methylations alter ribosome biogenesis and structure, thereby affecting mRNA translation and the tumorigenic phenotypes in glioblastoma.

Research Keywords

Cancer stem cells, Chemoresistance, Glioblastoma, Notch pathway, Ovarian cancer, RNA methylation, RNA methyltransferase, Signaling pathway