An experimental combination drug therapy attacking the DNA integrity of cancer cells is showing promise for a possible new cancer therapy in the future.
Scientists at the University of Alberta used two drugs together to enhance DNA damage to human breast cancer cells in mice and reduce their capacity to repair themselves. By doing so, the researchers were able to dramatically shrink tumours and prevent metastasis in the mice.
"Most cancers don't kill patients because of the primary tumour. It's nearly always the metastasis that kills," said Armin Gamper, an assistant professor of oncology at the U of A.
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