Publications

Alexander R.T.

 

Trepiccione F, Gerber SD, Grahammer F, López-Cayuqueo KI, Baudrie V, Paunescu TG, Picard N, Alexander RT, Huber TB, Chambrey R, Brown D, Houillier P, Eladari D and Simons  M. Renal (Pro)renin receptor/Atp6ap2 is required for normal V-ATPase function but not for the renin-angiotensin systemJ Am Soc Nephrol, 2016 Nov;27(11):3320-3330.

Almomani E, Lashhab R, Alexander RT, and Cordat E. The carboxyl-terminally truncated kidney anion exchanger 1 R901X dRTA mutant is unstable at the plasma membrane. Am J Physiol Cell Physiol, 2016 May 1;310(9):C764-72.

Sinning A, Radionov N, Trepiccione F, López-Cayuqueo KI, Jayat M, Baron S, Cornière N, Alexander RT, Hadchouel J, Eladari D, Hübner CA, Chambrey R.  Double knock-out of Na+-driven Cl-/HCO3- exchanger (NDCBE) and Na-Cl cotransporter (NCC) induces hypokalemia and volume depletion. J Am Soc Nephrol, 2017 Jan;28(1):130-139.

Pais R, Rievaj R, Meek C, De Costa G, Jayamaha S, Alexander RT, Reimann F, and Gribble F. Role of enteroendocrine L-cells in Arginine Vasopressin - mediated inhibition of colonic anion secretion. J Phys 2016 Sep 1;594(17):4865-78.

Ramesh A, Peleh V, Martinez-Caballero S, Wollweber F, Sommer F, van der Laan M, Schroda M, Alexander RT, Campo ML, Herrmann JM. A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import. J Cell Biol. 2016 Aug 15;214(4):417-31.

Kondapalli KC, Alexander RT, Pluznick JL, Rao R. NHA2 is expressed in distal nephron and regulated by dietary sodium. J Physiol Biochem. 2017 May;73(2):199-205.

Ure MEHeydari EPan WRamesh ARehman S, Morgan C, Pinsk M, Erickson R, Hermann JM, Dimke H, Cordat E, Lemaire M, Walter M, Alexander RT. A variant in a cis-regulatory element enhances claudin-14 expression and is associated with pediatric-onset hypercalciuria and kidney stones. Human Mutation. 2017 Jun;38(6):649-657.

Beggs MR, Appel I, Svenningsen P, Skjødt KAlexander RT, Dimke HExpression of Trans- and Paracellular Calcium and Magnesium Transport Proteins in Renal and Intestinal Epithelia During Lactation. Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F629-F640.

Krishnan D, Pan, W, Beggs MR, Trepiccione F, Chambrey R, Eladari D, Cordat E, Dimke H, Alexander RT. Deficiency of carbonic anhydrase II results in a urinary concentrating defect. Front. Physiol. 2017 (In Press)

King AJ, Siegel M, He Y, Nie B, Wang J, Koo-McCoy S, Minassian N, Jafri Q, Pan D, Kohler J, Kumaraswamy P, Kozuka K, Lewis J, Dragoli D, Rosenbaum DP, O’Neil DPlain A, Greasley PJ, Jonsson-Rylander A, Karlsson D, Behrendt M, Stromstedt M, Ryden-Bergsten T, Marks J, Arroyo EMP, Hernando N, Donowitz M, Wagner CA, Alexander RT#, Caldwell JS#. Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability” Science Translational Medicine 2018, # - shared senior authorship (Accepted).

Saban JA, Zappitelli M, Samuel SM, Sood MM, Alexander RT, Arora S, Erickson RL, Kroeker K, Manns BJ, Dart AB. Perceptions of pediatric nephrologists regarding timing of dialysis initiation in children in Canada. Can J Kidney Health Dis 2016, Jul 1;3:31

Bolduc FV, Lau A, Rosenfelt CS, Langer S, Wang N, Smithson L, Lefebvre D, Alexander RT, Dickson CT, Li L, Becker AB, Subbarao P, Turvey SE, Pei J, Sears MR, Mandhane PJ.Cognitive Enhancement in Infants Associated with Increased Maternal Fruit Intake During Pregnancy: Results from a Birth Cohort Study with Validation in an Animal Model. EBioMedicine 2016 Jun;8:331-40.

Dart AB, Zappitelli M, Sood MM, Alexander RT, Arora S, Erickson RL, Kroeker K, Soo A, Manns BJ, Samuel SM. Variation in estimated glomerular filtration rate at dialysis initiation in children.2017 Peadiatr Nephrol Feb;32(2):331-340.

Alexander, RT, McArthur E, Jandoc R, Welk B, Hayward JS, Jain AK, Braam B, Flockerzi V, Garg AX, Quinn RR. Antihypertensive Medications and the Risk of Kidney Stones in Older Adults: A Retrospective Cohort Study. Hypertension Research2017 Sep;40(9):837-842.

Alexander, RT, McArthur E, Jandoc R, Welk B, Fuster D, Garg AX, Quinn RR. Thiazide Diuretic Dose and the Risk of Kidney Stones in Older Adults: A Retrospective Cohort Study. Can J Kidney Health & Disease, 2018 (Accepted).

(Review Papers)

Alexander RT & Bockenhaur D. Chapter 35: Renal Tubular Acidosis. In Pediatric Kidney Disease, 2nd Edition. Editors; Geary D & Schaefer F. Springer. 2017

Alexander RT, Cordat E, Chambrey R, Dimke H, Eladari D. Acidosis and Urinary Calcium Excretion: Insights from Genetic Disorders. J Am Soc Nephrol. 2016 Dec;27(12):3511-3520.

Alexander RT. Urinary Sodium Excretion and calcium excretion: via Endothelin-1 do they part? J Physiol 2017 Apr 15;595(8):2415-2416.

Beggs MRAlexander RT. Intestinal Absorption and Renal Reabsorption of Calcium Throughout Postnatal Development. Experimental Biology and Medicine. 2017 Apr;242(8):840-849.

Alexander, R. T. and Dimke, H. Effect of Diuretics on Renal Tubular Transport of Calcium and Magnesium. Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F998-F1015.

Lee JJ, Plain A, Beggs MR, Dimke H, Alexander RTEffects of phospho- and calciotropic hormones on electrolyte transport in the proximal tubule. F1000Res. 2017 Oct 3;6:1797.

King AJ1, Siegel M, He Y, Nie B, Wang J, Koo-McCoy S, Minassian NA, Jafri Q, Pan D, Kohler J, Kumaraswamy P, Kozuka K, Lewis JG, Dragoli D, Rosenbaum DP, O’Neill D, Plain A, Greasley PJ, Jönsson-Rylander AC, Karlsson D, Behrendt M, Strömstedt M, Ryden-Bergsten T, Knöpfel T, Pastor Arroyo EM, Hernando N, Marks J, Donowitz M, Wagner CA, Alexander RT, Caldwell JS. – Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.

Alexander R.T., Cordat E., Chambrey R., Dimke H., Eladari D. (2016) – “Acidosis and urinary calcium excretion, insights from genetic disorders”. In press for Journal of the American Society of Nephrology.

Krishnan D, Liu L, Wiebe SA, Casey JR, Cordat E, Alexander RT. (2015) Carbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3. Am J Physiol Renal Physiol. 309(4):F383-92.

Vilas G, Krishnan D, Loganathan SK, Malhotra D, Liu L, Beggs MR, Gena P, Calamita G, Jung M, Zimmermann R, Tamma G, Casey JR, Alexander RT. (2015) Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction.. Mol Biol Cell. Mar 15;26(6):1106-18.

 

Alexander RT, Beggs MR, Zamani R, Marcussen N, Frische S, Dimke H. (2015) Ultrastructural and Immunohistochemical Localization of the Plasma Membrane Ca2+-ATPase 4 (PMCA4) in Ca2+-Transporting Epithelia. Am J Physiol Renal Physiol. Jul 15:ajprenal.00651.2014. doi: 10.1152/ajprenal.00651.2014. 

Krishnan D, Liu L, Wiebe SA, Casey JR, Cordat E, Alexander RT. (2015) Carbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3. Am J Physiol Renal Physiol. 309(4):F383-92.

Vilas G, Krishnan D, Loganathan SK, Malhotra D, Liu L, Beggs MR, Gena P, Calamita G, Jung M, Zimmermann R, Tamma G, Casey JR, Alexander RT. (2015) Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction. Mol Biol Cell. Mar 15;26(6):1106-18.

Alexander RT, Hemmelgarn BR, Wiebe N, Bello A, Samuel S, Klarenbach SW, Curhan GC, Tonelli M. (2014) for the Alberta Kidney Disease Network.  Kidney stones and cardiovascular events:  a cohort study.  Clin J Am Soc NephrolMar;9(3):506-12.

Fuster DG and Alexander RT. (2014) Traditional and Emerging Roles of the SLC9 Na+/H+ exchangers.  Pflugers Arch Jan;466(1):61-76.

Dimke H, Desai P, Borovac J, Lau A, Pan W, Alexander RT. (2013) Activation of the Ca2+-Sensing Receptor Increases Renal Claudin-14 Expression and Urinary Ca2+ Excretion.  Am J Physiol Renal Physiol Mar 15;304(6):F761-9.

Alexander RT, Dimke H, Cordat E. (2013) Proximal Tubular NHEs:  Sodium, Protons and Calcium?  Am J Physiol Renal Physiol Aug;305(3):F229-36.

Rievag J, Pan W, Cordat E, Alexander RT. (2013) The Na+/H+ Exchanger Isoform 3 is required for active paracellular and transcellular Ca2+ transport across murine caecum. Am J Physiol Gastrointest Liver Physiol Aug;305(4):G303-13.

 

 

Pan W, Borovac J, Spicer Z, Hoenderop JG, Bindels RJ, Shull GE, Doschak MR, Cordat E, Alexander RT. (2012) The Epithelial Sodium Proton Exchanger, NHE3, is necessary for renal and intestinal calcium (re)absorption. Am J Physiol Renal Physiol, 2(8):F943-56. (I am senior and corresponding Author).

Samuel SM, Foster BJ, Tonelli MA, Nettel-Aguirre A, Soo A, Alexander RT, Hemmelgarn BR; (2012) Association between distance from renal care center and death in pediatric end-stage renal disease patients. Pediatr Transplant  Nov;16(7):735-41.

Alexander RT, Foster BJ, Tonelli MA, Soo A, Nettel-Aguirre A, Hemmelgarn BR and Samuel SM; (2012) the Pediatric Renal Outcomes Canada Group. Outcomes of Children Less than 2 years of Age initiating dialysis. Pediatr Nephrol. Oct;27(10):1975-83.

Almomani EY, King JC, Netsawang J, Yenchitsomanus PT, Malasit P, Limjindaporn T, Alexander RT, Cordat E. (2012) Adaptor protein 1 complexes regulate intracellular trafficking of the kidney anion exchanger 1 in epithelial cells. Am J Physiol Cell Physiol. Sep;303(5):C554-66.

Samuel SM, Foster BJ, Hemmelgarn BR, Nettel-Aguirre A, Crowshoe L, Alexander RT, Soo A, Tonelli MA. (2012) Incidence and causes of end-stage renal disease among Aboriginal children and young adults. CMAJ.  Oct 2;184(14):E758-64.

Borovac J, Barker RS, Rasmussen A, Pan W, Wevrick R and Alexander RT. (2012) Claudin-4 forms a paracellular barrier, revealing the interdependence of claudin expression in the loose epithelial cell culture model opossum kidney cells. Am J Physiol Renal Physiol,  Dec;303(12):C1278-91. (I am Corresponding Author).

Alexander RT, Jaumouillé V, Yeung T, Furuya W, Peltekova I, Boucher A, Zasloff M, Orlowski J, Grinstein S.EMBO J. (2011) Membrane surface charge dictates the structure and function of the epithelial Na+/H+ exchanger. 30(4):679-91.

 

Casey, J.R.

 


 

Yang, Y., Seo-Meyer, P., Lezon-Geyda, K., Badior, K.E., Casey, J.R., Li, J., Reithmeier, R.A.F. and Gallagher, P.G. (2018) A Homozygous Ser725Arg Mutation in the Anion-binding Site of Band 3 (SLC4A1) Abolishes Transport Function Causing Transfusion Dependent Anemia and Distal Renal Tubular Acidosis Blood131, 1759-1763.

Alka, K. and Casey, J.R. (2018) Molecular Phenotype of SLC4A11 Missense Mutants: Setting the Stage for Personalized Medicine in Corneal Dystrophies, Human Mutation39, 676-690. Featured as cover for this issue of the journal.

Badior, K., Alka, K., and Casey, J.R. (2017) SLC4A11 Three-Dimensional Homology Model Rationalizes Corneal Dystrophy-causing Mutations, Human Mutation38, 279-288.

Loganathan, S.K., Schneider, H.P., Morgan, P.E., Deitmer, J.W., and Casey, J.R. (2016) Functional Assessment of SLC4A11, an Integral Membrane Protein Mutated in Corneal Dystrophies, Am. J. Physiol., In Press.

Loganathan, S.K., Lukowski, C.M. and Casey, J.R. (2016) The cytoplasmic domain is essential for transport function of the integral membrane transport protein SLC4A11, Am. J. Physiol., 310, C161‐174.

 

Chiu, A.M., Mandziuk, J.J., Alka, K., Loganathan, S.K., and Casey, J.R. (2015) High Throughput Assay Identifies Glafenine as a Chemical Corrector for the Folding Defect in Corneal Dystrophy‐Causing Mutants of SLC4A11, Invest. Opthal. and Vis. Sci., 56, 7739‐53.

Krishnan D, Liu L, Wiebe SA, Casey JR, Cordat E, Alexander RT. (2015) Carbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3. Am J Physiol Renal Physiol. 309(4):F383-92.

Vilas G, Krishnan D, Loganathan SK, Malhotra D, Liu L, Beggs MR, Gena P, Calamita G, Jung M, Zimmermann R, Tamma G, Casey JR, Alexander RT. (2015) Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction. Mol Biol Cell. Mar 15;26(6):1106-18.

Okawa, Y., Li, J., Basu, A., Casey, J.R. and Reinhart A.F. Reithmeier (2014) Differential Roles of Tryptophan Residues in the Functional Expression of Human Anion Exchanger 1 (AE1, Band 3, SLC4A1) Molecular Membrane Biology26:1-17.

Vilas, G.L., Krishnan, D., Loganathan, S.K., Malhotra, D., Liu, L., Beggs, M., Gena, P., Calamita, G., Jung, M., Zimmermann, R., Tamma, G., Casey, J.R. and Alexander, R.T. (2015), Increased Water Flux Induced by an Aquaporin-1/Carbonic Anhydrase II interaction, Mol. Biol. of Cell., 26, 1106-18

Malhotra, D. and Casey, J. R. (2015) Intracellular pH Measurement. In: eLS. John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0002643.pub3

Alka, K. and Casey J.R. (2014) Bicarbonate Transport in health and disease, IUBMB Life66:596-615.

Zoccola, D., Ganot, P., Bertucci, A., Caminiti-Segonds, N., Techer, N., Voolstra, C., Aranda, M., Tambutté, E., Allemand, D., Casey, J.R. and Sylvie Tambutté (2015) Bicarbonate Family Transporters In A Scleractinian Coral, Scientific Reports. In Press.

Bonar, P.T., Schneider, H.P., Becker, H.M., Deitmer, J.W., and Casey, J.R. (2013) Three-Dimensional Model for the Huma Cl-/HCO3- Exchange, AE1, by Homology to the E. coli CIC Protein, J. Mol. Biol. 425, 2591-2608.

Vilas, G.L., Loganathan, S., Liu, J., Riau, A.K., Young, J.D., Mehta, J.S., Vithana, E.N. and Casey, J.R. (2013) Transmembrane water flux through SLC4A11:  a route defective in corneal diseases, Human Mol. Genet. 22, 4579-90.

Shnitsar, V., Li, J., Li, X., Calmettes, C., Basu, A., Casey, J.R., Moraes, T.F. and Reithmeier, R.A.F. (2013) Structural and Functional Analysis of a Putative Substrate Access Tunnel in the Cytosolic Domain of Human Anion Exchanger 1 (AE1, Band 3, SLC4A1), J. Biol. Chem., 28833848-60.

Alvarez, B.V., Quon, Mullen, J. and Casey, J.R. (2013) Quantification of Carbonic Anhydrase Gene Expression  in Ventricle of Hypertrophic and Failing Human Heart, BMC- Cardiovascular Disorders 13:2.

Vilas, G.L., Loganathan, S., Quon, A., Sundaresan, P., Vithana, E.N and Casey, J.R. (2012) Oligomerization of SLC4A11 protein and the severity of FECD and CHED2 corneal dystrophies caused by SLC4A11 mutations,Human Mutation33, 419-428.

Brown, B., Quon, A., Dyck, J. and Casey, J.R. (2012) Carbonic Anhydrase II Promotes Cardiomyocyte Hypertrophy, Can. J. Physiol. Pharmacol. 90, 1599-610.

Vilas, G.L., Morgan, P.E., Loganathan, S., Quon, A., and Casey, J.R. (2011) Biochemical Framework for SLC4A11, the Plasma Membrane Protein Defective in Corneal Dystrophies Biochemistry, 50, 2157-69.

Johnson, D.E. and Casey, J.R. (2011) Cytosolic H+ Microdomain Developed Around AE1 During AE1-Mediated Cl-/HCO3- Exchange, J. Physiol.589, 1551-69.

De Guisti, V., Orlowski, A., Villa-Abrille, M., Chiappe de Cingolani, G., Casey, J.R., Alvarez, B.V., Aeillo, E. (2011) Antibodies Against the Cardiac Sodium/Bicarbonate Cotransporter (NBCe1) as a Pharmacological Tool, British Journal of Pharmacology164, 1976-89.

Sowah, D. and Casey, J.R. (2011) An Intramolecular Transport Metabolon:  Fusion of Carbonic Anhydrase II to the C-terminus of the Cl-/HCO3- Exchanger, Am J Physiol 301, C336-46.


Chen, X.-Z.       

 

 

Zheng, W., Yang, X., Hu, R., Cai, R., Hofmann, L., Wang, Z., Hu, Q., Liu, X., Tang, J.,  Tsiokas, L., Yu, Y., Flockerzi, V., Cao, Y., Cao, E., and Chen, X.-Z.* PKD2 and PKD2L1 polycystin channels: characterization of hydrophobic pore gates and channel gating. Nature Commun. In press.

Benedikt Frei, Cornelia Eisenach, Enrico Martinoia, Shaimaa Hussein, Xing-Zhen Chen, Stephanie Arrivault, and H. Ekkehard Neuhaus. Functional characterization of the vacuolar malate trans-porter tDT from Arabidopsis. J Biol Chem. In press, 2018.

Zheng, W., Cai, R., Hofmann, L., Nesin, V., Hu, Q., Liu, X., Hussein, S., Kong, T., Li, J., Tang, J., Flockerzi, V., Tsiokas, L., and Chen, X.-Z.* Direct preS1-TRP domain binding mediates gating and functional regulation of TRP channels by PIP2. Cell Rep. 22, 1560-1573, 2018.

Zheng, W., Hu, R., Cai, R., Hofmann, L., Hu, Q., Fatehi, M., Long, W., Kong, T., Light., P., Tang, J., Flockerzi, V., Cao., Y., and Chen, X.-Z.* Identification and characterization of hydrophobic gates in TRP channels. FASEB J. 2, 639-653, 2018. 

Tang, Y., Wang, Z., Yang, J., Zheng, W., Chen, D., Sandford, R., Tang, J., and Chen, X.-Z.* Polycystin-1 inhibits eIF2 phosphorylation and cell apoptosis through a PKR-eIF2 pathway. Sci. Rep. 7, 11493, 2017.

Hofmann, L., Wang, H., Zheng, W., Philipp. S.E., Cavalié, A., Chen, X.-Z., Beck., A., and Flockerzi, V. The S4-S5-linker - gearbox of TRP channel gating. Cell Calcium. S0143-4160 (17) 30045-3, 2017.

Zhou, C., Cheng, H., Qin, W., Zhang, Y., Xiong, H., Yang, J., Huang, H., Wang, Y., Chen, X.-Z., and Tang, T. Pygopus2 inhibits the efficacy of paclitaxel-induced apoptosis and induces multidrug resistance in human glioma cells. Oncotarget. 8, 27915-27928, 2017.

Long, W., Panigrahi, R., Panwar, P., Wong, K., O'Neill, D., Chen, X.-Z., Lemieux, J., and Cheeseman, C.I. Identification of key residues for urate specific transport in human glucose transporter (hSLC2A9). Sci. Rep. 7, 41167, 2017. 

Zheng, W., Shen, F., Hu, R., Roy, B., Yang, J., Wang, Q., Zhang, F., King, J.C., Sergi, C., Liu, S.‐M., Cordat, E., Tang, J., Cao, Y., Ali, D.W., and Chen, X.‐Z.* Far upstream element‐binding protein 1 binds the untranslated region of PKD2 and suppresses its translation. J. Am. Soc. Nephrol. Epub ahead of print, 2016. doi:10.1681/ASN.2015070836.

Hussein, S., Zheng, W., Dyte, C., Wang, Q., Yang, J., Zhang, F., Tang, J., Cao, Y., and Chen, X.‐Z.* Acidinduced off‐response of PKD2L1 channel in Xenopus oocytes and roles of Ca2+. Sci. Rep. 5, 15752, 2015. DOI: 10.1038/srep15752.

Wentong Long,  Pankaj Panwar, Kate Witkowska, Kenneth Wong, Debbie O'Neill, Xing-Zheng Chen, M Joanne Lemieux, Chris I. Cheeseman. (2015) Critical Roles for Two Hydrophobic Residues within Human Glucose Transporter 9 (hSLC2A9) Affecting Substrate Selectivity and the Energetics of Urate Transport J Biol Chem. pii: jbc.M114.611178.

Wang, Q., Dai., X.-Q., Li, Q., Tuli, J., Liang, G., Li, S. and Chen, X.-Z.* (2013) Filamin interacts with ENaC and inhibits its channel function. J. Biol. Chem., 288, 264-273.

Yang, J., Zheng, W., Wang, Q., Lara, C., Hussein, S., and Chen, X.-Z.* (2013)  Translational up-regulation of polycystic kidney disease protein PKD2 by endoplasmic reticulum stress. FASEB J. 27, 4998-5009.

Wang, Q., Dai, X.-Q., Wang, Z., Li, Q., Cantero, M.R., Li, S., Shen, J., Tu, J.-C., Cantiello, H.F. and Chen, X.-Z.* (2012) Structural interaction and functional regulation of polycystin-2 by filamin PLoS ONE. 7, e40448.
        
Yang, J., Wang, Q., Zheng, W., Tuli, J., Li, Q., Wu, Y., Hussein, S., Dai, X.-Q., Shafiei, S., Li, X.-G., Shen, P.Y., Tu, J.-C., and Chen, X.-Z.* (2012) Receptor for activated C kinase 1 (RACK1) inhibits the function of TRP-type channel Pkd2L1 through physical interaction. J. Biol. Chem. 287, 6551-6561.

 

 


Cordat, E.

 

 

 

Almomani E.Y., Touret N., Cordat E*. (2018) – “Adaptor protein 1 B mu subunit does not contribute to the recycling of kAE1 protein in polarized renal epithelial cells “. In press in Molecular membrane Biology, doi.org/10.1080/09687688.2018.1451662

Krishnan D, Pan W, Beggs M, Trepiccione F, Chambrey R, Eladari D, Cordat E, Dimke H, Alexander RT. (2018) – “Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect”. Frontiers in Physiology, Renal and Epithelia Physiology, 8:1108. doi: 10.3389/fphys.2017.01108.

Ure ME, Heydari E, Pan W, Ramesh A, Rehman S, Morgan C, Pinsk M, Erickson R, Herrmann JM, Dimke H, Cordat E, Lemaire M, Walter M, Alexander RT (2017) – “A variant in a cis-regulatory element enhances claudin-14 expression and is associated with pediatric-onset hypercalciuria and kidney stones.” Human Mutation. 2017 Jun;38(6):649-657. doi: 10.1002/humu.23202. 

Mumtaz R., Trepiccione F., Hennings J.C., Huebner A.K., Serbin B., Ullah S.A., Paunescu T., Capen D., Lashhab R.M., Mouro-Chanteloup I., ALper S.L., Wagner C.A., Cordat E., Brown D., Eladari D., Hubner C.A. (2017) – “Type A intercalated cell depletion and V-ATPase mistargeting in AE1 R607H knock-in mice modeling human dominant distal renal tubular acidosis”. Journal of the American Society of Nephrology, 28(5):1507-1520. doi: 10.1681/ASN.2016020169

Chang H.F., Bzeih H., Schirra C., Halamani M., Cordat E., Krause E., Pattu V., Rettig J. (2016) – “Endocytosis of cytotoxic granules is essential for multiple killing of target cells by T lymphocytes Journal of Immunology, 197(6):2473-84. doi: 10.4049/jimmunol.1600828. 

Peleh, V., Cordat E., Herrmann JM. (2016) – “Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding”, in press at eLife, doi: 10.7554/eLife.16177.

 

Almomani E, Lashhab R, Alexander RT, Cordat E. The carboxyl-terminally truncated kidney anion exchanger 1 R901X dRTA mutant is unstable at the plasma membrane. Am J Physiol Cell Physiol. 2016 May 1;310(9):C764-72. doi: 10.1152/ajpcell.00305.2015. Epub 2016 Mar 16

 

Zheng, W., Shen, F., Hu, R., Roy, B., Yang, J., Wang, Q., Zhang, F., King, J.C., Sergi, C., Liu, S.‐M., Cordat, E., Tang, J., Cao, Y., Ali, D.W., and Chen, X.‐Z.* Far upstream element‐binding protein 1 binds the untranslated region of PKD2 and suppresses its translation. J. Am. Soc. Nephrol. Epub ahead of print, 2016. doi:10.1681/ASN.2015070836.


Cordat E.* (2015)‐ “Setting up an academic research laboratory in Canada in 2015”. Canadian Journal of Kidney health and Disease. 2:51, doi: 10.1186/s40697‐015‐0086‐1.

Krishnan D, Liu L, Wiebe SA, Casey JR, Cordat E, Alexander RT. (2015) Carbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3. Am J Physiol Renal Physiol. 309(4):F383-92.

Cordat, E.  and Reithmeier, R.A. (2014) Structure, function, and trafficking of SLC4 and SLC26 anion transporters.  Curr. Top Membr. 78:1-67.

Chu, C.Y., King, J.C., Berrini, M., Alexander, R.T., and Cordat, E. (2013) Functional rescue of a kidney anion exchanger 1 trafficking mutant in renal epithelial cells.  PLoS One, 8(2):e57062.

Almomani, E.Y., King, J., Netsawang, J., Yenchitsomanus, P.T., Malasit, P., Limjindapron, T., Alexander, R.T., and Cordat, E. (2012) Adaptor protein 1 complexes regulate intracellular trafficking of the kidney anion exchanger 1 in epithelial cells. American Journal of Physiology, Cell Physiology 303(5):C554-66.

Pan, W., Borovac, J., Spicer, Z., Hoenderop, J.G., Bindels, R.J., Schull, G.E., Doschak, M.R., Cordat, E. and RT. Alexander, R.T.  (2011) The epithelial sodium-hydrogen exchanger, NHE3, is necessary for renal and intestinal calcium (re)absorption. Am J Physiol Renal Physiol, 2(8):F943-56.

Almomani E., Chu C. and Cordat E. (2011) Mis-trafficking of bicarbonate transporters: implications to human diseases. Biochemistry and Cell Biology, 89(2):157-77.

 

 

Fliegel, L.

 

 

X. Li,A. Augustine, S.Chen, L. Fliegel. Stop Codon Polymorphisms in the Human SLC9A1 Gene Disrupt or Compromise Na+/H+ Exchanger Function. (2016) PLoS ONE 11(9): e0162902. doi:10.1371/ journal.pone.0162902

SR Amith, Krista Marie Vincent, Jodi Marie Wilkinson, Lynne Marie Postovit, and Larry Fliegel. (2017) Defining the Na+/H+ Exchanger NHE1 interactome in triple-negative breast cancer cells. Cellular Signalling 29:69-77. DOI 10.1016/j.cellsig.2016.10.005

Larry Fliegel. (2017) β-Raf Activation of the Myocardial Na+/H+Exchanger. Channels 11:3181-182. Invited Review.DOI: 10.1080/19336950.2016.1270150

SRAmith, L. Fliegel (2017) Na+/H+ exchanger-mediated hydrogen ion extrusion as a carcinogenic signal in triple-negative breast cancer etiopathogenesis and prospects for its inhibition in therapeutics. Seminars in Cancer Biology 43:35-41 DOI 
10.1016/j.semcancer.2017.01.004    authors.elsevier.com/a/1V2WQ,Nm413VrC

Ayo Odunewu-Aderibigbe and L. Fliegel  Protein Mediated Regulation of the NHE1 Isoform of the Na+/H+ Exchanger in Renal Cells. Cellular Signaling 2017 Aug;36:145-153. doi: 10.1016/j.cellsig.2017.05.003

Ayo Odunewu-Aderibigbe and L. Fliegel  Heat Shock Proteins and the Na+/H+ Exchanger. Channels, 2017 :1-3. doi: 10.1080/19336950.2017.1347001

 

Amith SR, Wilkinson JM and Fliegel L. Characterization of the role of phosphorylation sites in regulation of the Na+/H+ exchanger (NHE1) in triple-negative MDA-MB-231 breast cancer cells. In Press in Oncotarget.

Ullah A, Dutta D, Fliegel L. Expression and characterization of the SOS1 Arabidopsis salt tolerance protein. Mol Cell Biochem. 2016 Apr;415(1-2):133-43. doi: 10.1007/s11010-016-2685-2. Epub 2016 Mar 18.PMID: 26992907

Claire Guissart, Xiuju Li, Bruno Leheup, Nathalie Drouot, Philippe Jonveaux, Larry Fliegel, Michel Koenig. (2015) Mutation of SLC9A1, encoding the major Na+/H+ exchanger, causes ataxia-deafness Lichtenstein Knorr syndrome. Human Molecular Genetics 24(2):463-70.  DOI 10.1093/hmg/ddu461

Schammim Ray Amith, Jodi Marie Wilkinson, S. Baksh and Larry Fliegel (2015) The Na+/H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells. Oncotarget 6(2):1262-75. Accession # 25514463 ISSN 1949-2553

Li, X. and Fliegel, L. (2015) A Novel Human Mutation in the SLC9A1 Gene Results in Abolition of Na+/H+ Exchanger Activity. Plos One 10(3) e0119453

Iman A. Mohamed, Alain-Pierre Gadeau, Gary Lopaschuk, Larry Fliegel, Mohamed Mlih, Nabeel Abdulrahman, Natasha Fillmore, Fatima Mraiche. Na+/H+ Exchanger Isoform 1-Induced Osteopontin Expression Facilitates Cardiomyocyte Hypertrophy Through p90 Ribosomal S6 Kinase. (2015) PLOS One 10(4) e0123318.

Amith, R.S, S. Fong, S. Baksh and L. Fliegel.  Na+/H+ Exchange in the Tumour Microenvironment: Does NHE1 Drive Breast Cancer Carcinogenesis?  International Journal of Developmental Biology.  In Press March 23, 2015. 

S.C. Guffey, L. Fliegel, G.G. Goss. (2015) Cloning and characterization of shark gill Na+/H+ Exchanger isoforms NHE2 and NHE3 from the Pacific dogfish Squalus suckleyi  In Press in Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology

Y. Liu, A. Basu, Xiuju Li and L. Fliegel.  Topological Analysis of the Na+/H+ Exchanger.  In Press BBA Biomembranes (July 22/2015)

Kemp, G., Fliegel, L., and Young, H.S.  (2014)  Membrane transport piece by piece:  production of transmembrane peptides for structural and functional studies.  Curr. Protoc. Protein Sci. 75:Unit 29 28.

Ullah, A., El-Magd, R.A., and Fliegel, L. (2014)  Functional role and analysis of cysteine residues of the salt tolerance protein Sod2.  Mol. Cell Biochem. 386:85-98.

Li, X., Prins, D., Michalak, M., and Fliegel, L. (2013)  Calmodulin-dependent binding to the NHE1 cytosolic tail mediates activation of the Na+/H+ exchanger by Ca2+ and endothelin.  Am. J. Physiol. Cell Physiol.  305:C1161-1169.

Ullah, A., Kemp, G., Lee, B.L., Alves, C., Young, H., Sykes, B.D. and Fliegel, L. (2013)  Structural and functional analysis of transmembrane segment IV of the salt tolerance protein Sod2.  J. Biol.Chem. 288:24609-24624.

Odunewu, A. and Fliegel, L. (2013)  Acidosis-mediated regulation of the NHE1 isoform of the Na(+)/H(+) exchanger in renal cells.  Am. J. Physiol. Renal Physiol. 305:F370-381.

Li, X., Khan, M.F., Schriemer, D.C., and Fliegel, L. (2013)  Structural changes in the C-terminal regulatory region of the Na(+)/H(+) exchanger mediate phosphorylation induced regulation.  J. Mol. Cell Cardiol. 61:153-163.

Amith, S.R. and Fliegel, L. (2013)  Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis.  Cancer Res.  73:1259-1264.

Lee, B.L., Sykes, B.D., and Fliegel, L. (2013)  Structural and functional insights into the cardiac Na(+)/H(+) exchanger.  J. Mol. Cell Cardiol. 61:60-67.

Blough, M.D., Al-Najjar, M., Chesnelong, C., Binding, C.E., Rogers,  A.D., Luchman, H.A., Kelly, J.J., Fliegel, L., Morozova, O., Yip, S., Marra, M., Weiss, S., Chan, J.A. and Cairncross, J.G.  (2012) DNA Hypermethylation and 1p Loss Silence NHE-1 in Oligodendroglioma.  Annals of Neurology 71(6):845-849.

Fliegel, L. Na+/H+ Exchangers, Structure, and Function: Role in Human Health and Disease. (2012) Encyclopedia of Metalloproteins. Springer Science.

Vanier, H.V., Mraiche, F., Li, X. and Fliegel, L. (2012) Gender specific effects of exercise on cardiac pathology in Na(+)/H(+) exchanger overexpressing mice. Mol Cell Biochem368:103-110.

Lee, B.L., Liu, Yonsheng, Li, X., Sykes, B.D. and Fliegel, L. (2012) Structural and functional analysis of extracellular loop 4 of the NHE1 isoform of the Na+/H+ exchanger. Biochim. Biophys. Acta 1818:2783-2790.

Mraiche, F. and Fliegel, L.  (2011)  Elevated expression in activatred Na(+)/H(+) exchanger protein induces hypertrophy in isolated rate neonatal ventricular cardiomyocytes. Mol. Cell. Biochem. 358:179-187.

Tzeng, J., Lee, B.L., Sykes, B.D. and Fliegel, L. (2011)  Structural and functional analysis of critical amino acids in TMV1 of the NHE1 isoform of the Na+/H+ exchanger.  Biochim. Biophys. Acta 1808:2327-2335.

Lee, B.L., Sykes, B.D. and Fliegel, L.  (2011) Structural analysis of the Na+/H+ exchanger isoform 1 (NHE1) using  the divide and conquer approach.  Biochem. Cell Biol. 89:189-199.

Alexander, R.T. and Fliegel, L.  (2011)  Report on the Na+/H+ Exchanger Satellite Meeting at the 53rd Annual Meeting of the Canadian Society of Biochemistry, Molecular and Cellular Biology.  Biochem. Cell Biol 89:85-86.

Mraiche, F., Oka, T., Gan, X.T., Karmazyn, M. and Fliegel, L.  (2011) Activated NHE1 is required to induce early cardiac hypertrophy in mice. Basic Research Cardiology 106:603-616.  

Karki, P., Li, X., Schrama, D. and Fliegel, L.  (2011) B-Raf associates with and activates the NHE1 isoform of the Na+/H+ exchanger.  J. Biol. Chem. 286(15):13096-13105.

Mraiche, F., Wagg, C.S., Lopaschuk, G.D. and Fliegel, L.  (2011) Elevated levels of activated NHE1 protect the myocardium and improve myocardial metabolism following ischemia/reperfusion injury. J. Mol. Cell. Cardiol. 50:157-164.   

 

 

Kurata, H.T.

 


Kim R.Y.,and †H.T. Kurata. 2018. Site-Directed Unnatural Amino Acid Mutagenesis to Investigate Potassium Channel Pharmacology in Xenopus laevis Oocytes. Methods Mol. Biol.1684: 253-263. PMID: 29058197

Macdonald, L.C., Kim, R.Y., Kurata, H.T., Fedida, D. 2018. Probing the molecular basis of hERG drug block with unnatural amino acids. Sci. Rep. 8(1): 289. PMID: 29321549

Baronas, V.A., Yang, R.Y., and †H.T. Kurata. 2017. Extracellular redox sensitivity of Kv1.2 potassium channels. Sci. Rep. 7(1):9142. PMID: 28831076

Kim, R.Y., Pless, S.A., and †H.T. Kurata. 2017. PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels. PNAS. 114(45):E9702- E9711. PMID: 29078287

Wang, A.W., Yang, R., and †H.T. Kurata. 2016. Sequence determinants of subtype-specific actions of KCNQ channel openers. J. Physiol. Epub August 9, 2016. PMID: 27506413.
†H.T. Kurata. 2016. Emerging complexities of lipid regulation of potassium channels. J. Gen. Physiol. 148(3):201-5. PMID: 27574290.

Wrobel, E., Rothenberg, I., Krisp, C., Hundt, F., Fraenzel, B., Eckey, K., Linders, J.T., Gallacher, D.J., Towart, R., Pott, L., Pusch, M., Yang, T., Roden, D.M., Kurata, H.T., Schulze-Bahr, E., Strutz-Seebohm N., Wolters, D., and Seebohm, G. 2016. KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmalogical targeting. Nature Communications. 7:12795. PMID: 27731317.
Kim, R.Y., Yau, M., Galpin, J.D., Ahern, C.A., Pless, S.A., and H.T. Kurata. 2015. Atomic basis for therapeutic activation of neuronal potassium channels. Nature Communications. 6:8116. PMID: 26333338.

Baronas, V., McGuinness, B.R., Brigidi, G.S., Gomm Kolisko, R.H., Vilin, Y.Y., Kim, R.Y., Lynn, F.C., Bamji, S.X., Yang, R.Y. and H.T. Kurata. 2015. Use-dependent activation of neuronal Kv1.2 channel complexes. J. Neurosci. 35(8):3515:3524. PMID: 25716850.

Pless, S.A., Kim, R.Y., Ahern, C.A., and H.T. Kurata. 2015. Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology. J. Physiol. 593(12):2627-2634. PMID: 25640301.

Zhang, R.S., Wright, J., Pless, S.A., Nunez, J.J., Kim, R.Y., Li, J.B.W., Yang, R., Ahern, C.A., and  H.T. Kurata. 2015. A conserved residue that governs kinetics of ATP-dependent gating of Kir6.2 potassium channels. J. Biol. Chem. 290(25):15450-61. PMID: 25934393.

Pless, S.A., Galpin, J.D., Niciforovic, A.P., Kurata, H.T., and C.A. Ahern. 2013. Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels. ELife, 2(0):e01289. PMID: 24327560.
Li, B.W., Huang, X., Zhang, R.S., Kim, R.Y., Yang, R., and H.T. Kurata. 2013. Decomposition of slide helix contributions to ATP-dependent inhibition of Kir6.2 channels. J. Biol. Chem.,288(32):23038-49. PMID: 23798684.

Pless, S.A., Niciforovic, A.P., Galpin, J.D., Nunez, J.J., Kurata, H.T., and C.A. Ahern. 2013. A novel mechanism for regulating open state stability in a voltage-gated potassium channel. Nature Communications, 4:1784).epub April 30, 2013.  PMID: 23653196

 

 

Lemieux, M.J.

 

Caldo KMP, Shen W, Xu Y, Hanley-Bowdoin L, Chen G, Weselake RJ, Lemieux MJ. -Diacylglycerol acyltransferase 1 is activated by phosphatidate and inhibited by SnRK1-catalyzed phosphorylation.

Arutyunova E, Jiang Z, Yang J, Kulepa AN, Young HS, Verhelst S, O’Donoghue AJ, Lemieux MJ. – An internally quenched peptide as a new model substrate for rhomboid intramembrane proteases.

Lemieux, MJ. Taking a position on intramembrane proteolysis. (2018) J Biol Chem

Bahitham W, Lian J, Panigrahi R,   Nelson R, Li L, Thiesen A, Lemieux MJ, Lehner R. Genetic Variation in Human Carboxylesterase 1D/Triacylglycerol Hydrolase (CES1D/TGH) Confers Protection Against Nonalcoholic Fatty Liver Disease. (2018) BBA Molecular and Cell Biology of lipids

 

Arutyunova, E., Panigrahi, R., Strisovsky, K., and Lemieux, M. J. (2017) Production of Recombinant Rhomboid Proteases. Methods in enzymology 584, 255-278

Arutyunova, E., Strisovsky, K., and Lemieux, M. J. (2017) Activity Assays for Rhomboid Proteases. Methods in enzymology 584, 395-437

Long, W., Panigrahi, R., Panwar, P., Wong, K., D, O. N., Chen, X. Z., Lemieux, M. J., and Cheeseman, C. I. (2017) Identification of Key Residues for Urate Specific Transport in Human Glucose Transporter 9 (hSLC2A9). Scientific reports 7, 41167

Soueidan, O. M., Scully, T. W., Kaur, J., Panigrahi, R., Belovodskiy, A., Do, V., Matier, C. D., Lemieux, M. J., Wuest, F., Cheeseman, C., and West, F. G. (2017) Fluorescent Hexose Conjugates Establish Stringent Stereochemical Requirement by GLUT5 for Recognition and Transport of Monosaccharides. ACS Chem Biol  Feb 16. doi: 10.1021/acschembio.6b01101. PMID: 28205432

Caldo KMP, Acedo JZ, Panigrahi R, Vederas JC, Weselake RJ, Lemieux MJ  (2017) Brassica napus diacylglycerol acyltransferase 1 is regulated by its hydrophilic N-terminal domain in response to allosteric effectors. Plant Physiology. 2017. vol. 175 pp 667-680. PMID:28827454

Xu X, Chen G, Greer M, Caldo KMP, Ramakrishnan G, Shah S, Wu L, Lemieux MJ, Ozga J, Weselake RJ. Different factors contribute to increased neutral lipid content in yeast producing plant DGAT1 variants (2017). J Biol Chem. 2017 Oct 27;292(43):17819-17831. doi: 10.1074/jbc.M117.811489.

Smeazzetto S, Armanious GP, Moncelli MR, Bak JJ, Lemieux MJ, Young HS, Tadini-Buoninsegni F. Conformational memory in the association of the transmembrane protein phospholamban with the sarcoplasmic reticulum calcium pump SERCA. (2017) J Biol Chem. Oct 29. pii: jbc.M117.794453. doi: 10.1074/jbc.M117.794453. [Epub ahead of print]. PMID: 29081402

Lemieux, MJ. Taking a position on intramembrane proteolysis. (2018) J Biol Chem

Bahitham W, Lian J, Panigrahi R,   Nelson R, Li L, Thiesen A, Lemieux MJ, Lehner R. Genetic Variation in Human Carboxylesterase 1D/Triacylglycerol Hydrolase (CES1D/TGH) Confers Protection Against Nonalcoholic Fatty Liver Disease. (2018) BBA Molecular and Cell Biology of lipids

Wentong Long,  Pankaj Panwar, Kate Witkowska, Kenneth Wong, Debbie O'Neill, Xing-Zheng Chen, M Joanne Lemieux, Chris I. Cheeseman. (2015) Critical Roles for Two Hydrophobic Residues within Human Glucose Transporter 9 (hSLC2A9) Affecting Substrate Selectivity and the Energetics of Urate Transport J Biol Chem. pii: jbc.M114.611178. 

Kristian Mark P. Caldo, Michael S. Greer, Guanqun Chen, M. Joanne Lemieux, Randall J. Weselake  (2015) Solubilization and Purification of Recombinant Brassica napus Diacylglycerol Acyltransferase 1. FEBS Lett.;589(6):773-8.34.    
Zoe Cournia, Tobby Allen, Ioan Andricioaei, Bruno Antonny, Daniel Baum, Grace Brannigan, Nicolae-Viorel Buchete, Jason T. Deckman, Lucie Delemotte, Coral del Val, Ran Friedman, Paraskevi Gkeka, Hans-Christian Hege, Jérôme Hénin, Marina Kasimova, Antonis Kolocouris, Michael L. Klein, Syma Khalid, M Joanne Lemieux, Norbert Lindow, Mahua Roy, Jana Selent, Mounir Tarek, Florentina Tofoleanu, Stefano Vanni, Sinisa Urban, David J. Wales, Jeremy C. Smith, Ana-Nicoleta Bondar (2015) Membrane Proteins: Environmental Effects on Structure, Function and Dynamics. J Mol. 8(4):611-40.

Christopher Girke, Elena A Arutyunova, Maria Syed, Michaela Traub, Torsten Mohlmann, M Joanne Lemieux. (2015) High yield purification and characterization of Equilibrative Nucleoside Transporter 7 (ENT7) from Arabidopsis thaliana. Biochim Biophys Acta 1850(9):1921-9.

Arutyunova, Panwar, P., Skiba, P.M., Gale, N., Mak,M.W., and Lemieux, M. Joanne  Allosteric regulation of rhomboid intramembrane proteolysis.  EMBOJ - in press.

Witz, S., Panwar, P., Schober, M., Deppe, J., Pasha, F.A., Lemieux, M. Joanne and Mohlmann, T.  (2014)  Structure-Function Relationship of a Plant NCS1 Member - Homology Modeling and Mutagenesis Identified Residues Critical for Substrate Specificity of PLUTO, a Nucleobase Transporter from Arabidopsis.  PLoS One, Mar 12;9(3):e91343.  doi: 10.1371/journal.pone.0091343.  eCollection 2014.

Brooks, C.L., Morrison, M., and Lemieux, M. Joanne (2013)  Novel plate screening technique for over-expression assessment of eukaryotic targets expressed in Pichia. Protein Science, 21 FEB 2013, DOI: 10.1002/pro.2223.

Lazareno-Saez, C., Arutyunova, E., Coquelle, N., and Lemieux, M. Joanne (2013)  Domain swapping in the cytoplasmic domain of E.coli rhomboid protease.  J. Mol. Biol. April 12;425(7):1127-1142.  doi: 10.1016/j.jmb.2013.01.019.

Padmapriya Sampathkumar, Michelle W. Mak, Sarah Withold, Emmanuel Guigard, Cyril M. Kay, M. Joanne Lemieux. (2012) Quaternary structure analysis of rhomboid intramembrane peptidases reveals a homodimer. BBA Biomembranes.(12):3090-3097.

Brooks, C.L., Lazareno-Saez, C., Lamoureux, J.S., Mak, M.W., and Lemieux, M.J. (2011)  Insights into substrate gating in H. influenzae rhomboid.  J. Mol. Biol. 407:687-697.      

 

 

Leslie, EM

 

 

Geib, T., LeBlanc, A., Shiao, T.C., Roy, R., Leslie, E.M., Karvellas, C.J., and Sleno, L. Absolute quantitation of acetaminophen-modified human serum albumin in acute liver failure patients
by LC-MS/MS. Rapid Commun Mass Spectrom. 32, 1573–1582 (2018).

 

Banerjee, M., Kaur, G., Whitlock, B.D., Carew, M.W., Le, X.C., and Leslie E.M. Multidrug Resistance Protein 1 (MRP1/ABCC1)-mediated cellular protection and transport of methylated arsenic metabolites differs between human cell lines.  Drug Metab. Dispos.  2018 May 11. pii: dmd.117.079640. doi: 10.1124/dmd.117.079640.

Liu, Q., Leslie, E.M., Moe, B., Zhang, H., Douglas, D.N., Kneteman, N.M., and Le, X.C.  Metabolism of a phenylarsenical in human hepatic cells and identification of a new arsenic metabolite. Environ. Sci. Technol. 52, 1386-1392. (2018).

Li, J., Burer, M., Moe, B., Leslie, E.M*., and  Li, XF*Multi-drug resistance protein 4 (MRP4/ABCC4) protects cells from the toxic effects of halobenzoquinones.  Chem. Res. Toxicol.  30, 1815−1822 (2017). *Joint senior authors

Liu, Q., Leslie, E.M., and Le, X.C. Characterization of roxarsone accumulation and transport using human immortalized Caco-2 cell line.  J. Agric. Food Chem. 64: 8902-08 (2016).

 

Roggenbeck, B.A., Banerjee, M. and Leslie, E.M.  Cellular arsenic transport pathways in mammals.  J. Environ. Sci.49:38-58. (2016) (invited review-Special Arsenic Issue for Dr. Bill Cullen).
 
Banerjee, M., Marensi, V., Conseil, G., Le, X.C., and Cole, S.P. and Leslie, E.M. Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions.  Biochem. Pharmacol. 120:72-82 (2016).

 

Shukalek, C.B., Swanlund, D.P., Rousseau, R.K., Weigl, K.E., Marensi, V., Cole, S.P. and Leslie, E.M.  Arsenic triglutathione [As(GS)3] transport by multidrug resistance protein 1 (MRP1/ABCC1) is selectively modified by phosphorylation of Tyr920/Ser921 and glycosylation of Asn19/Asn23.  Mol. Pharmacol.  90: 127-139 (2016). 
 
Kaur G., Leslie E.M., Battenhouse H., Lee W.M., Swanlund D.P. and Karvellas, C.J. Detection of Ophthalmic Acid in Serum from Acetaminophen-induced Acute Liver Failure Patients is More Frequent in Non-survivors.  PLoS One. 2015 Sep 25;10(9):e0139299. doi: 10.1371/journal.pone.0139299. eCollection 2015
 
Roggenbeck, B.A., Carew, M.W., Charrois, G., Douglas, D., Kneteman, N., Lu, X., Le, X.C., and Leslie, E.M. Characterization of Arsenic Hepatobiliary Transport Using Sandwich Cultured Human Hepatocytes.  Toxicol. Sci.  145:  307-20 (2015).   Editor’s Highlight

Banerjee, M.,* Carew, M.W.,* Roggenbeck, B.A., Whitlock, B.D., Naranmandura, H., Le, X.C., and Leslie, E.M.  A Novel Pathway for Arsenic Elimination:  Human Multidrug Resistance Protein 4 (MRP4/ABCC4) Mediates Cellular Export of Dimethylarsinic Acid (DMAV) and the Diglutathione Conjugate of Monomethylarsonous acid (MMAIII).  Mol. Pharmacol. 86:  168-79 (2014).  *Equally contributed to the work.

 

Possamai, L.A., McPhail, M.J., Quaglia, A., Zingarela, V., Abeles, R.D., Tidswell, R., Puthucheary, Z., Rawal, J., Karvellas, C.J., Leslie, E.M., Hughes, R.D., Ma, Y., Yassem, W., Shawcross, D.L. Bernal, W., Dharwan, A., Heaton, N.D., Thursz, M., Wendon, J.A., Mitry, R.R., and Antoniades, C.G.  (2013)  Character and Temporal Evolution of Apoptosis in Acetaminophen-induced Acute Liver Failure.  Crit. Care Med.  41:2543-2550.

Leslie, E.M.   (2012)  Arsenic Glutathione Conjugate Transport by the Human Multidrug Resistance Proteins (MRPs/ABCCs).  J. Inorg. Biochem. 108:141-149 (invited review).


Naranmandura, H., Carew, M.W., Lee, J., Leslie, E.M., Weinfeld, M., and Le, X.C.  (2011)  Comparative Toxicity of Arsenic Metabolites in Human Bladder Cancer EJ-1 Cells.  Chem. Res. Toxicol. 24:1586-2596.

Qazi, S.S., Osoria Pérez, A., Sam, M. and Leslie, E.M.  (2011)  Glutathione Transferase P1 (GSTP1) Interacts Strongly with the Inner Leaflet of the Plasma Membrane.  Drug. Metab. Dispos. 39:1122-1126. 

   

Carew, M.W., Naranmandura, H., Shukalek, C.B., Le, X.C., and Leslie, E.M.  (2011)  Monomethylarsenic Diglutathione [MMAIII(GS)2] Transport by the Human Multidrug Resistance Protein 1 (MRP1/ABCC1). Drug Metab. Dispos.  39:2298-2304.

 


Overduin, M.

 

 

Salim M, Knowles TJ, Hart R, Mohammed F, Woodward MJ, Willcox CR, Overduin M, Hayday AC, Willcox BE. (2016) Characterisation of a putative receptor binding surface on Skint‐1, a critical determinant of dendritic epidermal T cell selection, J. Biol. Chem. in press. PMID: 26917727.

Fogl C,  Mohammed F,  Al‐Jassar C,  Jeeves M, White C, Overduin M and Chidgey M, Molecular mechanism for intermediate filament recognition by plakin proteins, Nature Communications, 7:10827. PMID: 26935805

Browning DF, Bavro VN, Mason J, Sevastsyanovich YR, Rossiter AE, Jeeves M, Wells TJ, Knowles T, Cunningham AF, Donald J, Palmer T, Overduin M, Henderson IR (2015) Cross-species chimeras reveal BamA POTRA and β-barrel domains must be fine-tuned for efficient OMP insertion, Mol Micro, 97(4):646-59

Lenoir M, M Grzybek, M Majkowski, S Rajesh, J Kaur, Ü Coskun and M Overduin (2015) Structural basis of dynamic membrane recognition by trans-Golgi network specific FAPP proteins, J Mol Biol. 427(4):966-81.

Jeeves M, L Quill, M Overduin, Structure-based Drug Design using NMR (2015) eMagRes 4, 231–240.

Kufareva I, M Lenoir, F Dancea, P Sridhar, E Rausch, C Bissig, J Gruenberg, R Abagyan, M Overduin (2014) Discovery of novel membrane binding structures and functions, Biochem Cell Biol, 92(6):555-563.

RK Koppisetti, YG Fulcher, A Jurkevic, SH Prior, J Xu, M Lenoir, M Overduin, and SR Van Doren (2014) Ambidextrous Binding of Membrane Bilayers by a Soluble Metalloproteinase, Nature Comms. 5:5552.

Lenoir, M, M Sugawara, J Kaur, LJ Ball, M Overduin (2014) Structural Insights into the Activation of the RhoA GTPase by the Lbc Oncoprotein, J Biol Chem, 289(34):23992-4004.

Butterworth S, Overduin M and Barr AJ (2014) Targeting Protein Tyrosine Phosphatase SHP2 for therapeutic intervention in cancer Future Med Chem 6(12):1423-37. PMID: 25329198.

Al-Jassar C, Bikker H, Overduin M, Chidgey M (2013) Mechanistic basis of desmosome-targeted diseases, J Mol Biol, 425(21):4006-22.

Al-Jassar C, Bernado, P, Chidgey M, Overduin M (2013) Hinged plakin domains provide specialized degrees of articulation in envoplakin, periplakin and desmoplakin, PLoS ONE 8(7): e69767. PMID: 23922795

Bissig C, M Lenoir, MC Velluz, I Kufarena,  R Abagyan, M Overduin, J Gruenberg* (2013) Viral infection controlled by calcium dependent recognition of late endosome-specific lipid by the Alix Bro1 domain, Dev Cell 25:364-73.
Lenoir, M and M Overduin (2013) PtdIns(4)P signalling and recognition sytems, Adv Exp Med Biol 991:59-83.

Rajesh S, P Sridhar, BA Tews, L Fénéant, L Cocquerel, D Ward, F Berditchevski, M Overduin (2012) Structural basis of ligand interactions of the large extracellular domain of tetraspanin CD81, J Virol 86(18):9606-16.

Rajesh S, Knowles TJ, Overduin M (2011)Production of membrane proteins without cells or detergents, New Biotechnology, 28(3):250-4.

Knowles, TJ, DF Browning, M Jeeves, R Maderbocus, S Rajesh, P Sridhar, E Manoli, D Emery, U Sommer, A Spencer, DL Leyton, D Squire, RR Chaudhuri, MR Viant, AF Cunningham, IR Henderson, M Overduin (2011) Structure and function of BamE within the outer membrane and the β-barrel assembly machine, EMBO Reports 12(2):123-8.

Rajesh S, Bago R, Odintsova E, Muratov G, Sridhar P, Rajesh S, Overduin M, Berditchevski F (2011) Binding to syntenin-1 defines a new mode of ubiquitin-based interactions regulated by phosphorylation, J Biol Chem. 286(45):39606-14.

Al-Jassar C, Knowles T, Jeeves M, Kami K, Bikker H, Overduin M, Chidgey M (2011) The nonlinear structure of the desmoplakin plakin domain and the effects of cardiomyopathy-linked mutations, J Mol Biol, 411(5):1049-61.

 

 

Touret, N.



Lipinski, T.*, Fitieh, A.*, St. Pierre, J., Ostergaard, H.L., Bundle, D.R. and Touret, N. (2013) Enhanced Immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to DCs via Dectin-1 by incorporating b-glucan.  J Immunol. [Epub ahead of print]

Goodridge, H. S., Underhill, D. M., & Touret, N. (2012). Mechanisms of fc receptor and dectin-1 activation for phagocytosis. Traffic, 13(8), 1062–1071.

Haile Y., Simmen K.C., Pasichnyk D., Touret N., Simmen T., Lu J.Q., Bleackley R.C., Giuliani F .  (2011)  Granule-Derived Granzyme B Mediates the Vulnerability of Human Neurons to T Cell-Induced Neurotoxicity.  J Immunol. 9(187):(4861-72). Impact Factor: 5.75

Prins D., Groenendyk J., Touret N, Michalak M.   (2011)  Modulation of STIM1 and capacitative Ca(2+) entry by the endoplasmic reticulum luminal oxidoreductase ERp57. EMBO Rep. 11(12):(1182-8). Impact Factor: 7.82 

Jaqaman K., Kuwata H., Touret N, Collins R., Trimble W.S., Danuser G., Grinstein S.  (2011)  Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function. Cell. 146(4):(593-606). Impact Factor: 32.4

 

 

Weiner, J.H.

 



Prehna, G., Zhang, G., Gong, X., Dusyk, M., Okon, M. McIntosh, L.P., Weiner, J.H. and Strynadka, N.C.J. (2012)  Protein Export via the Escherichia coli Porin Channel. Structure 20:1154-1166.

         
Tran, Q.M., Fong, C., Rothery, R.A., Maklashina, E., Cecchini, G. and Weiner, J.H. (2012)  Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenase PLOS One 7:e32641.

         
Rothery, R.A., Stein, B., Solomonson, M.W., Kirk, M.L. and Weiner, J.H. (2012)  Pyranopterin conformation defines the function of molybdenum and tungsten enzymes Proc. Natl. Acad. Sci (USA) 109:14773-14778.

Cherney, M.M., Zhang, Y., James, M.N.G., and Weiner, J.H. (2012)  Structure-activity characterization of sulfide:quinone oxidoreductase variants J. Struct. Biol. 178:319-328.

Tang, H., Rothery, R.A., Voss, J. E. and Weiner, J.H.  (2011)  Correct Assembly of FS0 into the Escherichia coli DMSO Reductase (DmsABC) is a Pre-requisite for Molybdenum Cofactor Insertion. J. Biol. Chem. ß:15147-15154.

 

 

Young, H.S.

 

 

 

 

Gorski, P.A., Ceholski, D.K., Young, H.S. (2018) Structure-function relationship of the SERCA pump and its regulation by phospholamban and sarcolipin. Advances in Experimental Medicine and Biology (in press)

 

Robia, S., Young, H.S. (2018) Skins cells prefer a slower calcium pump. Journal of Biological Chemistry (in press).

 

Primeau, J.O., Armanious, G.P., Fisher, M.E., Young, H.S. (2018) The SarcoEndoplasmic Reticulum Calcium ATPase. Subcellular Biochemistry 87:229-59.

 

Smeazzetto, S.*, Armanious, G.A.*, Moncelli, M.R., Bak, J.J., Lemieux, M.J., Young, H.S.#, Tadini-Buonunsegni, F.# (2017) Conformational memory in the association of the transmembrane protein phospholamban with the sarcoplasmic reticulum calcium pump SERCA. Journal of Biological Chemistry 292:21330-9. *Co-first authors; #Co-corresponding authors.

 

Vázquez-Fernández, E.Young, H.S., Requena, J.R., Wille, H. (2017) The structure of mammalian prions and their aggregates. Int Rev Cell Mol Biol 329:277-301.

 

Gorski, P.A., Trieber, C.A., Ashrafi, G., Young, H.S. (2015) Regulation of the sarcoplasmic reticulum calcium pump by divergent phospholamban isoforms in zebrafish. Journal of Biological Chemistry 290:6777-88.

Young, H.S., Ceholski, D.K., Trieber, C.A. (2015) Deception in simplicity: Hereditary phospholamban mutations in dilated cardiomyopathy. Biochemistry and Cell Biology 93:1-7.

Abrol, N., Smolin, N., Armanious, G., Ceholski, D.K., Trieber, C.A., Young, H.S., Robia, S.L. Phospholamban C-terminal residues are critical determinants of the structure and function of the calcium ATPase regulatory complex. Journal of Biological Chemistry 289:25855-66.

Muller, M., Kunz, H.H., Schroeder, J., Kemp, G., Young, H.S., and Neuhaus, E.  (2014)  Decreased capacity of sodium import into Arabidopsis chloroplasts impairs salt tolerance, photosynthesis and plant performance.  The Plant Journal (in press).

Kemp, G., Fliegel, L., and Young, H.S. (2014)  Membrane Transport Piece by Piece: Production of Transmembrane Peptides for Structural and Functional Studies.  Current Protocol in Protein Science Curr Protoc Protein Sci. 2014 Feb 3;75:Unit 29.8.

Ullah, A., Kemp, G., Lee, G., Alves, C., Young, H.S., Sykes, B.D., and Fliegel, L.  (2013)  Structural and functional analysis of transmembrane segment IV of the salt tolerance protein sod2.  Journal of Biological Chemistry  288:24609-24624.

Gorski, P.A., Glaves, J.P., Vangheluwe, P., and Young, H.S. (2013)  Sarco/endoplasmic reticulum calcium ATPase (SERCA) inhibition is encoded in its luminal tail.  Journal of Biological Chemistry 288:8456-8467.

Smeazzetto, S., Saponaro, A., Young, H.S., Monicelli, M.R., and Thiel, G.  (2013)  Structure-function relation in phospholamban:  Modulation of channel activity as a potential regulator of SERCA activity.  PLoS One 8:(1):e52744.

Cortez, M., Kumar, J., Renault, L., Young, H.S., and Sim,  V.L.  (2013)  Mouse prion protein polymorphism 108F/189V affects the kinetics of fibril formation and the response to seeding; evidence for a two-step nucleation polymerization mechanism.  Journal of Biological Chemistry 288:4772-4781.

Glaves, J.P., Gorski, P.A., Alier, K., Ma, L., Primeau, J.O., Jhamandas, J.H., and Young, H.S.  (2013)  Distinct morphological and electrophysiological properties of an elk prion peptide.  Peptides  40:49-56.

Ceholski, D.K., Trieber, C.A., and Young, H.S.  (2012)  Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy.  Journal of Biological Chemistry  287:16521-16529.

Ceholski, D.K., Trieber, C.A., Holmes, C.F., and Young, H.S.  (2012)  Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A.  Journal of Biological Chemistry  287:26596-26605.

Gorski, P.A., Trieber, C.A., Lariviere, E., Schuermans, M., Wuytack, F., Young, H.S. and Vangheluwe, P.  (2012)  Transmembrane helix 11 is a genuine regulator of the endoplasmic reticulum Ca2+ pump and acts as a functional parallel of b-subunit on a-Na+, K+-ATPase.  Journal of Biological Chemistry  287:19876-19885.

Chaulk, S., Thede, G.L., Kent, O.A., Xu, Z., Gesner, E., Veldhoen, R.A., Khanna, S.K., Goping, I.S., MacMillan, A.M., Mendell, J.T., Young, H.S., Fahlman, R.P., Glover, J.N.M. (2011)  Role of pri-miRNA structure in miR-17~92 biogenesis. RNA Biology  8:1105-14.

 

Misono, K., Philo, J., Arakawa, T., Ogata, C., Qiu, Y., Ogawa, H., Young, H.S. (2011) Structure, signaling mechanism and regulation of natriuretic peptide receptor-guanylate cyclase. FEBS Journal 278:1818-29.3.   

Glaves, J.P., Trieber, C.A., Ceholski, D.K., Stokes, D.L., Young, H.S. (2011) Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump. Journal of Molecular Biology 405:707-23.

 

 

Young, J.D.

 

Damaraju, V, Surapaneni, S, Kumar, G, Ng, AM, Yao, SYM, Young, JD, Cass, CE and Tong, Z. (2012). Role of human nucleoside transporters in the uptake and cytotoxicity of azacitidine and decitabine.  Nucleosides, Nucleotides & Nucleic Acids 31:236-255.

Huysmans, GH, Chan, N, Baldwin JM, Postis, VL, Tzokov, SB, Deacon, SE, Yao, SYM, Young, JD, McPherson, MJ, Bullough, PA, Baldwin, SA. (2012). A urea channel from Bacillus cereus reveals a novel hexameric structure.  Biochem. J. 445:157-166.

Witkowska K, Smith, KM, Yao, SYM, Ng, AML, O.Neill, D, Karpinski, E, Young, JD, Cheeseman, CI.  (2012). Human SLC2A9a and SLC2A9b isoforms mediate electrogenic transport of urate with different characteristics in the presence of hexoses. Am. J. Physiol. Renal Physiol. 303:F527-539.

Vaziri, H, Baldwin, SA, Baldwin JM, Adams DG, Young, JD, Postis, VL. (2012). Use of molecular modelling to probe the mechanism of the nucleoside transporter NupG. Mol. Membr. Biol. [Epub ahead of print, Dec. 21] .

Damaraju, V.L., Smith, K.M., Mowles, D., Nowak, I., Karpinski, E., Young, J.D., Robins, M. and Cass C.E.  Interaction of fused-pyrimidine nucleoside analogs with human concentrative nucleoside transporter 1.  Mol. Pharmacol. 81:82-90 (2011). PubMed Accession Number: 20854794.  [Journal Impact factor 4.53]

Graham, K., Yao, S.Y.M., Johnson, L., Mowles, D., Ng, A.M.L., Wilkinson, J., Young, J.D. and Cass, C.E.  Nucleoside transporter gene expression in wild-type and mENT1 knockout mice.  Biochem. Cell Biol. 89:236-2145 (2011).  PubMed Accession Number: 21455274. [Journal Impact factor 2.61]

Kost, S., Sun, C., Graham, K., Cass, C.E., Young, J.D., Albensi, B.C. and Parkinson, F.E.  Behavioral effects of elevated expression of human equilibrative nucleoside transporter 1 in mice.  Behav. Brain Res. 224:44-49 (2011).  PubMed Accession Number: 21645551.  [Journal Impact factor 3.22]

Yao, S.Y.M., Ng, A.M.L., Cass, C.E., Baldwin, S.A. and Young, J.D.  Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1).  J. Biol. Chem.  286:32552-32562 (2011).  PubMed Accession Number: 21795683.  [Journal Impact factor 5.52]

Damaraju, V.J., Mowles, D., Smith, K.M., Yao, S.Y.M., Young, J.D., Marquez, V.E. and Cass, C.E.  Influence of sugar ring conformation on transportability of nucleosides by human nucleoside transporters.  Chem. Bio. Chem. [Epub ahead of print, Nov. 4, 2011].  PubMed Accession Number: 22052809.  [Journal Impact factor 3.82]