Postdoctoral Fellow with Dr. Anastassia Voronova: Exploring cytokines as novel re-myelination therapy in multiple sclerosis

Postdoctoral fellow or Ph.D. student with Dr. Anastassia Voronova: Exploring cytokines as novel re-myelination therapy in multiple sclerosis

Neural precursor cells in adult mammalian brain, such as subventricular zone (SVZ) neural stem cells and oligodendrocyte precursors in brain parenchyma, form oligodendrocytes throughout life. The purpose of oligodendrocytes is to produce myelin, an insulating material that performs vital functions in efficient neural information transmission and constitutes the brain white matter. How oligodendrocyte populations are formed and maintained by neural precursors is currently unclear. Postdoctoral fellow or Ph.D. candidate will investigate the effect of developmentally important brain cytokines on neural precursors in normal and injured adult murine brain. The production of oligodendrocyte lineage cells and/or new myelin will be investigated using transgenic animals under normal or demyelinating conditions. Other techniques will include intracerebroventricular injections (live animal surgery), primary cell culture, qPCR, RNA-sequencing, western blots, immunohistochemistry and confocal microscopy. The resulting information may lead to development of novel remyelination therapies for demyelinating disorders such as multiple sclerosis, pediatric leukodystrophy and lysosomal storage disease.

An ideal candidate will be highly motivated and can work as a team player and a leader. Preference will be given to applicants with previous rodent experience and/or extensive cell or developmental biology expertise. Highly motivated Ph.D. students ready to learn live animal surgeries and work collaboratively and responsibly are also encouraged to apply. Salary for potential postdoctoral fellow with commensurate with experience. Position will be open until filled.

Candidates should submit a cover letter including research interests, complete CV including a brief summary of previous graduate thesis and/or post-doctoral research (if applicable), transcripts (unofficial is suitable), and the names and contact information of at least two academic referees.

E-mail applications to voronova@ualberta.ca. Only applicants selected for an interview will be contacted.