Graduate Students and Postdoctoral Fellow with Dr. Glen Jickling: Immune response in stroke and Stroke Transcriptomics

Dr. Glen Jickling
4-065 Katz Building
glenj@ualberta.ca

Dr Jickling's group is studying the genomics and genetics of stroke. It is a translational research group studying the molecular biology of patients with stroke and neurological disease, and applying these findings to stroke models in-vivo and in-vitro.

The lab has two major focuses

1. Immune response in stroke. Novel methods to treat and prevent stroke including microRNA regulation of inflammation; relationship of immune activation to thrombosis and endothelial dysfunction.

2. Stroke Transcriptomics: RNA biomarkers to identify and phenotype patients with stroke, TIA; to predict complications that worsen outcome; to predict response to treatment. Relationship of RNA expression to genetic and clinical phenotype in stroke.

Methods employed include

  • RNA Sequencing
  • microarray
  • Digital PCR and RT-PCR
  • SNP analysis
  • High dimensional genomic data analysis
  • Prediction modelling
  • Cell culture
  • microRNA transfection and targeting
  • Blood brain barrier modelling
  • Stroke models
  • Single cell sequencing
  • FACS