Davidge Lab Publications

Kaul P, Savu A, Davidge ST, Cooke C-L. Association between offspring birth weight, preterm birth, and the risk of cardiovascular disease and mortality in the mother: a population-level analysis, in review

Jahandideh F, Bourque SL, Armstrong EA, Cherak S, Panahi A, Macala KM, Davidge ST, Yager JY. Prenatal uteroplacental ischemia increases susceptibility to postnatal high-fat high-sucrose diet-induced fat accumulation in female but not male adult offspring, in review 

Do V, Eckersley L, Lin L, Davidge ST, Stickland MK, Ojala T, Hornberger LK. Persistent aortic stiffness and left ventricular hypertrophy in 3-8 year old children of diabetic mothers, in review 

Spaans F, Quon A, Morton JS, Kirschenman R, Sawamura T, Tannetta DS, Sargent IL, Davidge ST. The Role of Lectin-like Oxidized LDL Receptor-1 and Syncytiotrophoblast Extracellular Vesicles in the Vascular Reactivity of Uterine Arteries during Late Pregnancy in Mice, in review

Kumar P, Morton JS, Shah A, Do V, Sergi C, Serrano-Lomelin J, Davidge ST, Beker D, Levasseur J, Hornberger L. Intrauterine exposure to chronic hypoxia in the rat leads to progressive diastolic function and increased aortic stiffness from early postnatal developmental stages. Physiological Reports, In press, November, 2019

Reyes LM, Farooq SM, Skow RJ, Busch SA, Pyke KE, Khurana R, Chari RS, Stickland MK, Devolin M, Davidge ST, Sobierajski F, Lugg A, Steinback CD, Davenport MH. Physical activity in pregnancy is associated with increased flow-mediated dilation. Med Sci Sports Exerc. 2019 Nov 1. doi: 10.1249/MSS.0000000000002201. [Epub ahead of print]

Napso T, Hung Y-P, Davidge ST, Care AS,  Sferruzzi-Perri AN. Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats. Sci Rep. 2019 Nov 28;9(1):16916. doi: 10.1038/s41598-019-53199-x

Morton JS, Levasseur J, Ganguly E, Quon A, Kirschenman R, Dyck JRB, Fraser GM, Davidge STCharacterisation of the Selective Reduced Uteroplacental Perfusion (sRUPP) Model of Preeclampsia. Sci Rep. 2019 Jul 2;9(1):9565. doi: 10.1038/s41598-019-45959-6.

Cooke C-LM and Davidge ST. Advanced maternal age and the impact on maternal and offspring cardiovascular health. Invited Review, Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H387-H394. doi: 10.1152/ajpheart.00045.2019. Epub 2019 Jun 14.

Steinback CD, Fraser GM, Usselman CW, Reyes LM, Julian C, Stickland MK, Chari R, Khurana R, Davidge ST, Davenport M. Blunted Sympathetic Neurovascular Transduction during Normotensive Pregnancy. J Physiol. 2019 Jul;597(14):3687-3696. doi: 10.1113/JP277714. Epub 2019 Jun 13.

Ganguly E, Aljunaidy MM, Kirschenman R, Spaans F, Morton JS, Phillips T, Case CP, Cooke CLM, Davidge STSex-specific Effects of Nanoparticle-Encapsulated MitoQ (nMitoQ) Delivery to the Placenta in a Rat Model of Fetal Hypoxia. Front Physiol. 2019 May 24;10:562. doi: 10.3389/fphys.2019.00562. eCollection 2019.

Shahid A, Patel V, Morton J, Davidge ST, Stenson T, Oudit G, McMurtry MS.  Low altitude simulation without hypoxia improves left ventricular function after myocardial infarction by reducing ventricular afterload. PLOS One, 14(5):e0215814, May, 2019

Loria AN, Goulopoulou S, Bourque SL, Davidge ST. Sex differences in the developmental programming of cardiovascular dysfunction. Chapter 18 in: Sex Differences in Cardiovascular Physiology and Pathophysiology (LaMarca B, Alexander B, eds.) Elsevier, April 22, 2019

Jahandideh F, de Campos S, Davidge ST, Chan CB, Proctor S, Wu J. Egg white hydrolysate enhances insulin sensitivity in high fat diet induced insulin resistant rats via AKT Activation. Br J Nutr. 2019 Jul 14;122(1):14-24. doi: 10.1017/S0007114519000837. Epub 2019 Jun 18.

Liao W, Fan H, Davidge ST, Wu J. Egg white-derived antihypertensive peptide IRW (Ile-Arg-Trp) reduces blood pressure in spontaneously hypertensive rats via the ACE2/Ang (1-7)/Mas receptor axis. Mol Nutr Food Res. 2019 May;63(9):e1900063. doi: 10.1002/mnfr.201900063. Epub 2019 Apr 10.

Do V, Al-Hashmi H, Ojala T, Jain V, Colen T, Goncalvez-Alvarez S, Davidge ST, Al-Rajaa Nm Serrano-Lomelin J, Stickland M, Hornberger LK. Cardiovascular health of offspring of diabetic mothers from the fetal through late infancy stages. Journal of the American College of Cardiology (JACC): Cardiovascular Imaging, 12(5):932-934, May, 2019

Spaans F, Quon A, Morton JS, Rowe SR, Kirschenman R, Sawamura T, Tannetta DS, Sargent IL, Davidge ST. Alterations in vascular function by syncytiotrophoblast extracellular vesicles via LOX-1 in mouse uterine arteries. Clin Sci (Lond). 2018 Nov 13;132(21):2369-2381. doi: 10.1042/CS20180639. Print 2018 Nov 15.

Liao W, Bhullar KS, Chakrabarti S, Davidge ST, Wu J. Egg white-derived tripeptide IRW (Ile-Arg-Trp) enhances activity and expression of angiotensin converting enzyme 2.  J Agric Food Chem, 66:11330-11336, Oct, 2018

Shah A, Cooke C-LM Kirschenman R, Quon AL, Morton JS, Care AS, Davidge ST. Sex-specific effects of advanced maternal age on cardiovascular function in aged adult rat offspring. Am J Physiol Heart Circ Physiol, 2018 Dec 1;315(6):H1724-H1734. doi: 10.1152/ajpheart.00375.2018. Epub 2018 Oct 5

Chakrabarti S, Jahandideh F, Davidge ST, Wu J. Milk-derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Pre-Adipocyte Cells. J Agric Food Chem 66(39):10179-1018, Sept, 2018

Wen SW, White RR, Rybak N, Gaudet L, Robson S, Hague W, Simms-Stewart D,  Carroli G, Smith G, Fraser W, Wells G, Davidge ST, Kingdom J, Coyle D, Fergusson D, Corsi DJ, Champagne J, Sabri E, Ramsay T, Mol BWJ, Oudijk M, Walker MC on behalf of the FACT collaborating group. Effect of folic acid supplementation in pregnancy on preeclampsia – FACT. BMJ. 2018 Sep 12;362:k3478. doi: 10.1136/bmj.k3478.

Cooke C-LM, Shah A, Kirschenman R, Quon A, Morton JS, Care AS, Davidge ST. Increased susceptibility to cardiovascular disease in offspring born from dams of advanced maternal age. J Physiol, 2018 Dec;596(23):5807-5821. doi: 10.1113/JP275472. Epub 2018 Jun 21.

Aljunaidy MM, Morton JS, Kirschenman R, Phillips T, Case CP, Cooke C-LM, Davidge ST. Maternal treatment with a placental-targeted antioxidant (MitoQ) impacts offspring cardiovascular function in a rat model of prenatal hypoxia. Pharmacological Research, 134:332-342, May, 2018

Care AS, Bourque SL, Morton JS, Hjartarson EP, Robertson SA, Davidge ST. Reduction of regulatory T cells during pregnancy causes uterine artery dysfunction in the mouse.  Hypertension. 2018 Jul;72(1):177-187. doi: 10.1161/HYPERTENSIONAHA.118.10858. Epub 2018 May 21.

Sobierajski F, Purdy G, Usselman C, Skow R, James M, Chari R, Khurana R, Sticklan M, Davidge ST, Devoli M, Steinback C, Davenport M. Maternal physical activity is associated with improved blood pressure control during late pregnancy. Can J Cardiol. 2018 Apr;34(4):485-491. doi: 10.1016/j.cjca.2018.01.021. Epub 2018 Jan 31.

Wang KCY, Larcombe AN, Berry LJ, Morton JS, Davidge ST, James AL, Noble PB. Fetal growth restriction in mice modifies postnatal airway responsiveness in an age and sex-dependent manner. Clin Sci (Lond). 2018 Jan 25;132(2):273-284. doi: 10.1042/CS20171554. Print 2018 Jan 31.

Reyes LM, Shah A, Quon A, Morton JS, Davidge ST. The role of the TNF-related weak inducer of apoptosis (TWEAK) in hypoxia-induced intrauterine growth restricted offspring. J Dev Orig Health Dis. 2018 Dec;9(6):661-669. doi: 10.1017/S2040174417001003. Epub 2017 Dec 18.

Schmidt S, Ussleman CW, Martinek E, Stickland MK, Julian C, Chari R, Khurana R, Davidge ST, Davenport M, Steinback CD. Activity of muscle sympathetic neurons during normotensive pregnancy. Am J Physiol Regul Integr Comp Physiol. 2018 Feb 1;314(2):R153-R160. doi: 10.1152/ajpregu.00121.2016. Epub 2017 Oct 18;   “APSselect” Award Winner

Jahandideh F, Chakrabarti S, Davidge ST, Wu J. Egg white hydrolysate shows insulin-mimetic and sensitizing effects in 3T3-F442A pre-adipocytes, PLoS One. 2017 Oct 3;12(10):e0185653. doi: 10.1371/journal.pone.0185653. eCollection 2017.

Aljunaidy MM, Morton JS, Cooke CL, Davidge ST. Prenatal Hypoxia and Placental Oxidative Stress: Linkages to Developmental Origins of Cardiovascular Disease, Invited Review, Am J Physiol, Regul Integr Comp Physiol, 313:R395-R399, Oct 1, 2017


Shah A, Matsumura N, Quon A, Morton JS, Dyck JRB, Davidge ST. Cardiovascular susceptibility to in vivo ischemic myocardial injury in male and female rat offspring exposed to prenatal hypoxia. Clin Sci (Lond). 2017 Aug 10;131(17):2303-2317. doi: 10.1042/CS20171122. Print 2017 Sep 1.; Editorial Commentary on this paper is the same issue 131, 2791-2794, 2017

Charkoudian N, Usselman CW, Skow RJ, Staab J, Julian CG, Stickland MK, Chari RS, Khurana R, Davidge ST, Davenport MH, Steinback CD.  Muscle sympathetic nerve activity and volume regulating factors in healthy pregnant and non-pregnant women. Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H782-H787. doi: 10.1152/ajpheart.00312.2017. Epub 2017 Jul 21.

Spaans F, Kao CK, Morton JS, Quon AL, Sawamura T, Tannetta DS, Sargent IL, Davidge ST. Syncytiotrophoblast extracellular vesicles impair rat uterine vascular function via the lectin-like oxidized LDL receptor-1. PLoS One. 2017 Jul 3;12(7):e0180364. doi: 10.1371/journal.pone.0180364. eCollection 2017.

Phillips TJ, Scott H, Menassa DA, Bignell AL, Sood A, Morton JS, Akagi T, Azuma K, Rogers MF, Gilmore CE, Inman GJ, Grant S, Chung Y, Aljunaidy MA, Cooke CL, Steinkraus BR, Pocklington A, Logan A, Collett GP, Kemp H, Holmans PA, Murphy MP, Fulga TA, Coney AM, Akashi M, Davidge ST. Case CP. Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development. Sci Rep. 2017 Aug 22;7(1):9079. doi: 10.1038/s41598-017-06300-1.

Morton JS, Care AS, Kirschenmann R, Cooke C-L, Davidge ST. Advanced maternal age worsens postpartum vascular function. Frontiers in Physiology, 8:465, June, 2017

Morton JS, Care AS, Davidge ST. Mechanisms for uterine artery dysfunction in pregnancy complications, Invited Review for Journal of Cardiovascular Pharmacology, 69:343-359, June 30, 2017

Wen SW, Tan H, Retnakaran R, Shen M, Zhou S, Xie RH, Smith GN, Davidge ST, Trasler J, Walker MC. Pre-gravid predictors of new onset hypertension in pregnancy - Results from a pre-conception cohort study in China. Eur J Obstet Gynecol Reprod Biol. 2017 Jul;214:140-144. doi: 10.1016/j.ejogrb.2017.05.008. Epub 2017 May 12.

Wang KCY, Morton JS, Davidge ST, Larcombe AN, James AL, DonovaN GM, Noble PB. Increased heterogeneity of airway calibre in adult rats after hypoxia-induced intrauterine growth restriction, Respirology. 2017 Oct;22(7):1329-1335. doi: 10.1111/resp.13071. Epub 2017 May 17

Chakrabarti S, Davidge ST, Wu J. Milk-derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) differentially modulate angiotensin II effects on vascular smooth muscle cells. Journal of Functional Foods 2017, March 30:151-158.

Plows JF, Budin F, andersson RAM, Mills VJ, Davidge ST, Vickers MH, Baker PN, Zolezzi IS, Stanley JS. The effects of Myo-inositol and B and D vitamins supplementation in the db/+ mouse model of gestational diabetes mellitus. Nutrients. 2017 Feb 15;9(2). pii: E141. doi: 10.3390/nu9020141.

Shah A, Quon A, Morton JS, Davidge ST. Postnatal resveratrol supplementation improves cardiovascular function in male and female intrauterine growth restricted offspring. Physiol Rep. 2017 Jan;5(2). pii: e13109. doi: 10.14814/phy2.13109.