Obstetrics & Gynecology

Maternal-Fetal Medicine Research

Research in the MFM  division includes participation in clinical trials, both locally initiated and Multicentre National Trials. The Division has been successful in obtaining funding from CIHR, Canadian Foundation for Women's Health, and WCHRI. The MFM group also actively leads population based studies, through collaboration with the Alberta Perinatal Health Program (APHP) and the Alberta  Congenital anomalies Surveillance System (ACASS).

The MFM division also collaborates with Pediatrics and its subspecialties, Diagnosistc Imaging and the reproductive sciences division in the Department of ObGyn.

Areas of Research Focus

  • Preclampsia /Preclampsia Prevention
  • Perinatal outcomes and interpregnancy intervals
  • Maternal Serum Biochemisrty and adverse Perinatal Outcomes
  • PPROM and Preterm Birth
  • Fetal Ultrasound
  • Exercise in Pregnancy
  • Predicting Lung Hypoplasisa
  • Fetal Echo and Fetal MRI
  • Medical Education
  • Basic and translational research in maternal aging
  • Basic and translational research in pregnancy outcomes

Clinical Research Collaborations

  • Synergy in Microbiota Research (SyMBIOTA)

    Principal Investigators: Anita L. Kozyrsky (University of Alberta), Allan B. Becker (University of Manitoba), David Guttman (University of Toronto), Kent T. Hayglass (University of Manitoba), Piush Mandhane (CHILD Study), James A. Scott (University of Toronto)
    Co-Investigators: Dean A. Befus (University of Alberta), Radha Chari (University of Alberta), Catherine J. Field (University of Alberta), Terry P. Klassen (Manitoba Institute of Child Health), Stuart E. Turvey (Child & Family Research Institute)
  • Data Mining and Newborn Outcomes (DOMiNO)

    Team: Dr. Osornio-Vargas, Dr. Irena Buka, Dr. Khalid Aziz, Dr. Manoj Kumar, Dr. Sue Chandra, Osnat Wine, Emily Chan , Dr. Osmar Zaiane, Dr. Sajib Barua, Dr. Yan Yuan, Dr. Yutaka Yasu, Jesus Serrano, Charlene Nielsen, Dr. Paul Villeneuve, Dr. Perry Hystad, Dr. Anne-Marie Nicols, Dr. Laura Arbour, Anders Erickson,  Dr. Eleanor Setton , Dr. Paul Demers, Dr. Prakeshkumar Shah, Dr. David Stieb, Dr. Phil Blagden, Nancy Aelicks, and Erica Phipps.

Representative Publications

  1. Relationship between interpregnancy interval and congenital anomalies.
    Chen I, Jhangri GS, Chandra S. Am J Obstet Gynecol. 2014 Jun;210(6):564.e1-8. doi: 10.1016/j.ajog.2014.02.002. Epub 2014 Feb 6.
    PMID: 24508646

  2. Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy.
    Woudstra DM, Chandra S, Hofmeyr GJ, Dowswell T. Cochrane Database Syst Rev. 2010 Sep 8;(9):CD008148. doi: 10.1002/14651858.CD008148.pub2. Review.
    PMID: 20824872   Free PMC Article

  3. Instruments for chorionic villus sampling for prenatal diagnosis.
    Young C, von Dadelszen P, Alfirevic Z. Cochrane Database Syst Rev. 2013 Jan 31;1:CD000114. doi: 10.1002/14651858.CD000114.pub2. Review.
    PMID: 23440775

  4. Maternal morbidity associated with early-onset and late-onset preeclampsia.
    Lisonkova S, Sabr Y, Mayer C, Young C, Skoll A, Joseph KS. Obstet Gynecol. 2014 Oct;124(4):771-81. doi: 10.1097/AOG.0000000000000472.
    PMID: 25198279

  5. Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.
    Azad MB, Konya T, Persaud RR, Guttman DS, Chari RS, Field CJ, Sears MR, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL; CHILD Study Investigators. BJOG. 2015 Sep 28. doi: 10.1111/1471-0528.13601. [Epub ahead of print]
    PMID: 26412384

  6. Regulation of Sympathetic Nerve Activity During the Cold Pressor Test in Normotensive Pregnant and Nonpregnant Women.
    Usselman CW, Wakefield PK, Skow RJ, Stickland MK, Chari RS, Julian CG, Steinback CD, Davenport MH. Hypertension. 2015 Oct;66(4):858-64. doi: 10.1161/HYPERTENSIONAHA.115.05964. Epub 2015 Aug 10.
    PMID: 26259593

  7. The effect of supervised prenatal exercise on fetal growth: a meta-analysis.
    Wiebe HW, Boulé NG, Chari R, Davenport MH. Obstet Gynecol. 2015 May;125(5):1185-94. doi: 10.1097/AOG.0000000000000801.
    PMID: 25932847

  8. SOGC Clinical Practice Guideline: Guidelines for the Management of a Pregnant Trauma Patient.
    Principal Authors: Jain V, Chari RS, Maslovits S, Farine D. 2015 June; No. 325.