Pharmacology

Quentin Pittman

Dr Quentin Pittman

Adjunct Professor

Education:
BA and Science - Major in Biology, University of Lethbridge, Lethbridge, 1972
PhD - Medical Physiology, University of Calgary, 1976

Website: www.acs.ucalgary.ca/~neuro/pittman/pittman.html

Research: Neuroimmune-endocrine interactions

Research Interests / Laboratory Techniques

Research activities focus on central autonomic control of fever, antipyresis and blood pressure and on the synaptic pharmacology of important endocrine and autonomic nuclei such as the supraoptic nucleus of the hypothalamus and the dorsal vagal complex. In addition, we study plasticity of neuronal function during pregnancy and lactation, and study the influence of neonatal immune challenges on adult autonomic function. We are interested in a number of transmitters including: cannabinoids, neuropeptides and amino acids.

Selected Recent Publications

Doenni VM, Song CM, Hill MN and Pittman QJ. (2016) Early-life inflammation with LPS delays fear extinction in adult rodents. Brain Behav Immun pii: S0889-1591(16)30524-4. [Epub ahead of print] PMID: 27888073

Marsters CM, Rosin JM, Thornton HF, Aslanpour S, Klenin N, Wilkinson G, Schuurmans C, Pittman QJ and Kurrasch DM. (2016) Oligodendrocyte development in the embryonic tuberal hypothalamus and the influence of Ascl1. Neural Dev 11(1):20. PMID: 27863528

Boychuk JA, Farrell JS, Palmer LA, Singleton AC, Pittman QJ and Teskey GC. (2017) HCN channels segregate stimulation-evoked movement responses in neocortex and allow for coordinated forelimb movements in rodents. J Physiol 595(1):247-263. PMID: 27568501

Doenni VM, Gray JM, Song CM, Patel S, Hill MN and Pittman QJ. (2016) Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. Brain Behav Immun 58:237-247. PMID: 27453335

Gray JM, Wilson CD, Lee TT, Pittman QJ, Deussing JM, Hillard CJ, McEwen BS, Schulkin J, Karatsoreos IN, Patel S and Hill MN. (2016) Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. Psychoneuroendocrinology 66:151-8. PMID: 26821211

Crosby KM, Baimoukhametova DV, Bains JS and Pittman QJ. (2015) Postsynaptic Depolarization Enhances GABA Drive to Dorsomedial Hypothalamic Neurons through Somatodendritic Cholecystokinin Release.J Neurosci 35(38):13160-70 PMID: 26400945

Nyuyki KD and Pittman QJ. (2015) Toward a better understanding of the central consequences of intestinal inflammation. Ann N Y Acad Sci 1351:149-54. PMID: 26378439

Harden LM, Kent S, Pittman QJ and Roth J. (2015) Fever and sickness behavior: Friend or foe? Brain Behav Immun 50:322-33. PMID: 26187566

Hussin AT, Boychuk JA, Brown AR, Pittman QJ and Teskey GC. (2015) Intracortical Microstimulation (ICMS) Activates Motor Cortex Layer 5 Pyramidal Neurons Mainly Transsynaptically. Brain Stimul 8(4):742-50. PMID: 25892002

Aavani T, Rana SA, Hawkes R and Pittman QJ. (2015) Maternal immune activation produces cerebellar hyperplasia and alterations in motor and social behaviors in male and female mice. Cerebellum 14(5):491-505. PMID: 25863812

Riazi K, Galic MA, Kentner AC, Reid AY, Sharkey KA and Pittman QJ. (2015) Microglia-dependent alteration of glutamatergic synaptic transmission and plasticity in the hippocampus during peripheral inflammation. J Neurosci 35(12):4942-52. PMID: 25810524 

D'Mello C, Riazi K, Le T, Stevens KM, Wang A, McKay DM, Pittman QJ, Swain MG. (2013) P-selectin-mediated monocyte-cerebral endothelium adhesive interactions link peripheral organ inflammation to sickness behaviors. J Neurosci 33(37):14878-88. PMID: 24027287