Pharmacology

Michael Zaugg

Dr Michael Zaugg

Adjunct Professor

Education:
eMBA-Health Care Managament/Hospital Finance-Alberta School of Business, 2011
FRCPC (Ottawa, Canada), 2008
Basic Science Fellowship-Cell Biology and Cardiovascular Physiology, State University of New York, 1997
MD-University of Zurich (Zurich, Switzerland), 1989

Teaching: PMCOL 415/515; PMCOL 425; PMCOL 402

Research: My research is focused on two main areas (a) mechanisms of organ protection against ischemia reperfusion injury in health and disease and (b) nutrition, metabolism, and health

Research Interests / Laboratory Techniques

Research in the Zaugg’s lab is translational in nature. Organ injuries and infections in the critically ill patient or in patients with comorbidities (heart disease or diabetes) undergoing surgery are a major concern for the perioperative physician. Our translational research projects in animal models and in patients investigate the mechanisms underlying novel therapies of organ protection, specifically heart protection by the aid of proteomics, transcriptomics, genomics, and more recently metabolomics.

Selected Recent Publications

1. Lucchinetti E, Lou PH, Gandhi M, Clanachan AS, Zaugg M. Differential Effects of Anesthetics and Opioid Receptor Activation on Cardioprotection Elicited by Reactive Oxygen Species-Mediated Postconditioning in Sprague-Dawley Rat Hearts. Anesth Analg. 2018;126(5):1739-1746. PMID: 29256935

2. Lou PH, Lucchinetti E, Scott KY, Huang Y, Gandhi M, Hersberger M, Clanachan AS, Lemieux H, Zaugg M. Alterations in fatty acid metabolism and sirtuin signaling characterize early type-2 diabetic hearts of fructose-fed rats. Physiol Rep. 2017;5(16). pii: e13388. doi: 10.14814/phy2.13388. PMID: 2883097

3. Zaugg M, Lou PH, Lucchinetti E, Gandhi M, Clanachan AS. Postconditioning with Intralipid emulsion protects against reperfusion injury in post-infarct remodeled rat hearts by activation of ROS-Akt/Erk signaling. Transl Res. 2017;186:36-51. PMID: 28641075

4. Raturi A, Gutiérrez T, Ortiz-Sandoval C, Ruangkittisakul A, Herrera-Cruz MS, Rockley JP, Gesson K, Ourdev D, Lou PH, Lucchinetti E, Tahbaz N, Zaugg M, Baksh S, Ballanyi K, Simmen T. TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux. J Cell Biol. 2016;214(4):433-44. PMID: 2750248

5. Aguirre JA, Lucchinetti E, Clanachan AS, Plane F, Zaugg M. Unraveling Interactions Between Anesthetics and the Endothelium: Update and Novel Insights. Anesth Analg. 2016;122(2):330-48. PMID: 26797549

6. Rigassi L, Barchiesi Bozzolo F, Lucchinetti E, Zaugg M, Fingerle J, Rosselli M, Imthurn B, Jackson EK, Dubey RK. 2-Methoxyestradiol blocks the RhoA/ROCK1 pathway in human aortic smooth muscle cells. Am J Physiol Endocrinol Metab. 2015;309(12):E995-1007. PMID: 26487003

7. Zaugg M, Lucchinetti E. Remote Ischemic Preconditioning in Cardiac Surgery--Ineffective and Risky? N Engl J Med. 2015;373(15):1470-2. PMID: 26436209

8. Lou PH, Lucchinetti E, Zhang L, Affolter A, Gandhi M, Zhakupova A, Hersberger M, Hornemann T, Clanachan AS, Zaugg M. Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking. Anesth Analg. 2015;120(2):329-40. PMID: 25437926

9. Lou PH, Lucchinetti E, Zhang L, Affolter A, Gandhi M, Hersberger M, Warren BE, Lemieux H, Sobhi HF, Clanachan AS, Zaugg M. Loss of Intralipid®- but not sevoflurane-mediated cardioprotection in early type-2 diabetic hearts of fructose-fed rats: importance of ROS signaling. PLoS One. 2014;9(8):e104971. doi: 10.1371/journal.pone.0104971. PMID: 25127027

10. Lou PH, Lucchinetti E, Zhang L, Affolter A, Schaub MC, Gandhi M, Hersberger M, Warren BE, Lemieux H, Sobhi HF, Clanachan AS, Zaugg M. The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases. PLoS One. 2014;9(1):e87205. doi: 10.1371/journal.pone.0087205. PMID: 24498043

11. Warren BE, Lou PH, Lucchinetti E, Zhang L, Clanachan AS, Affolter A, Hersberger M, Zaugg M, Lemieux H. Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat. Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E658-67. PMID: 24425766

12. Zhang L, Jaswal JS, Ussher JR, Sankaralingam S, Wagg C, Zaugg M, Lopaschuk GD. Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy. Circ Heart Fail. 2013;6(5):1039-48. PMID: 23861485

13. Lou PH, Zhang L, Lucchinetti E, Heck M, Affolter A, Gandhi M, Kienesberger PC, Hersberger M, Clanachan AS, Zaugg M. Infarct-remodelled hearts with limited oxidative capacity boost fatty acid oxidation after conditioning against ischaemia/reperfusion injury. Cardiovasc Res. 2013;97(2):251-61. PMID: 23097573