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Kehrer-2010

James Kehrer, PhD

Professor (on administrative leave)

Pharmacy and Pharmaceutical Sciences

About Me

James P. Kehrer received a B.S. in pharmacy from Purdue University in 1974 and a Ph.D. in pharmacology/toxicology from the University of Iowa in 1978. He did postdoctoral work from 1978-1980 at Oak Ridge National Laboratory. In 1980, he was appointed to the faculty at the University of Texas at Austin. From 1991-2004 he was Head of the Division of Pharmacology and Toxicology in the College of Pharmacy. In 2005 he became Dean of the College of Pharmacy at Washington State University and in 2009 he became Dean of the Faculty of Pharmacy and Pharmaceutical Sciences at the University of Alberta. Dr. Kehrer has served on numerous NIH grant review panels, as a member of the US-EPA Science Advisory Board Exposure and Human Health Committee, and on the US-FDA Nonprescription Drug Advisory Committee. His research has been in the areas of free radicals, oxidative stress, cell signaling and apoptosis. He received the Achievement Award from the Society of Toxicology, a Research Career Development Award from the National Institutes of Health and is a Fellow of the American Association for the Advancement of Science. He has published 145 papers and one book.


Research

•Molecular mechanisms by which acrolein, a cyclophosphamide metabolite, affects apoptosis and cell proliferation; effects on signal transduction including NFκB

•Thioredoxin and apoptosis; role of thioredoxin in signaling

•Mechanisms of apoptosis induced by lipoxygenase and cyclooxygenase-2 inhibitors; role of lipocalin expression (24p3 and NGAL) and Akt signaling pathways

•Free radical toxicology; glutathione and apoptosis signaling



Teaching