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Paul-Jurasz-7739

Paul Jurasz, PhD

Associate Professor

Pharmacy and Pharmaceutical Sciences | Medicine & Dentistry

Pharmacology

About Me

Education:

2005-2008   Postdoctoral Fellow

Terrance Donnelly Vascular Biology Research Labs

Department of Cardiology

St. Michael’s Hospital, Toronto, Ontario

Supervisor: Dr. Duncan J. Stewart

            

2002-2005  Postdoctoral Fellow

Institute of Molecular Medicine for the Prevention of Human Diseases

Department of Integrative Biology and Pharmacology

University of Texas Health Sciences Center-Houston 

Houston, Texas, USA

Supervisor: Dr. Marek Radomski


1998- 2002 PhD

Department of Pharmacology

University of Alberta, Edmonton, Canada

Supervisor: Dr. Marek Radomski


1994-1998 BSc with Distinction

 University of Alberta, Edmonton, Canada

 

Member:

University of Alberta Cardiovascular Research Centre

Mazankowski Alberta Heart Institute 


Research

Platelets are cell fragments physiologically known for maintaining hemostasis and pathologically for forming thrombi that occlude arteries and veins. These traditional roles of platelets have been known since the late 19th century. However, recent investigations from several laboratories around the world have demonstrated that platelets also play an important role regulating angiogenesis (new blood vessel growth). Platelets constitutively generate the potent angiogenesis inhibitor angiostatin as they circulate. In addition, they contain abundant pro- and anti-angiogenic mediators such as vascular endothelial growth and thrombospondin, which upon release from platelets granules help regulate new blood vessel growth. 

In my laboratory, in addition to studying the traditional roles of platelets, we study the pharmacological regulation of platelet-derived angiogenesis mediators in an attempt to inhibit growth of blood vessels to tumors and to promote therapeutic blood vessel growth for cardiovascular disease. Specifically, we are investigating the role of platelet-derived angiostatin plays in limiting angiogenesis, and how its production is regulated by serine and matrix metalloproteinases. Further, we are interested in how nitric oxide and protein kinase C signaling pathways influence the release of angiogenesis mediators from platelets. Finally, we are exploring how these platelet-derived angiogenesis mediators influence endothelial cell growth, migration, and ability to form capillaries.

Current Funding:

Canadian Institutes of Health Research

Heart and Stroke Foundation of Alberta 


Teaching

Undergraduate Teaching:

Ph347 Hematology module - course coordinator

Ph307 Dermatology/ENT module - contributor

Ph341 Pharmaceutical Analysis - contributor

Ph467 Oncology module - contributor

PMCOL344 Scientific Basis of Pharmacology II - contributor

PMCOL415 Cardiovascular Pharmacology - contributor


Graduate Teaching:

Ph566 Cellular Drug Targets - contributor

Ph573 Analytical Techniques in Pharmaceutical Sciences - course coordinator