Cardiovascular
Researchers: Dr. Fakhreddin Jamali, Dr. Paul Jurasz , Dr. John Seubert , Dr. John Ussher, Dr. Dion Brocks & Dr. Khaled Barakat
Computational Drug Discovery
Research in this area uses tools to discover new antiviral and immune checkpoints’ small molecule drugs and specializes in understanding the nature and biophysical processes underlying protein-drug interaction, protein-protein interactions, protein-DNA interactions, drug off-target interactions and predicting drug-mediated toxicity.
Researchers: Dr. Khaled Barakat
Drug Delivery
A field that concentrates on formulation methods and technologies that are employed to transport pharmaceutical compounds to various sites in the body. It may include synthetic drug carrier systems capable of improving the bioavailability and/or tissue-specific targeting of an active pharmaceutical ingredient (API) to the site of desired drug action, such as bone drug delivery, or drug targeting of cancer cells.
Researchers: Dr. Neal Davies, Dr. Michael Doschak, Dr. Afsaneh Lavasanifar & Dr. Raimar Löbenberg
Medical Chemistry
Researchers: Dr. Carlos Velázquez & Dr. Khaled Barakat
Neurology/Critical Care
Research in this area aims for improving outcomes in patients with neurological emergencies (subarachnoid hemorrhage, intracerebral hemorrhage, ischemic stroke, traumatic brain injury and status epilepticus) and patients with epilepsy through pharmacotherapy optimization of existing therapies and translation of new treatments.
Researchers: Dr. Sherif Mahmoud
Obesity/Type 2 Diabetes
Researchers: Dr. John Ussher
Pharmacodynamics
Studies what a drug does to the body. Drug effect involves receptor binding, post-receptor effects, and biochemical interactions. It is a drug's pharmacokinetics that determines the onset, duration, and intensity of a drug's effect.
Researchers: Dr. Dion Brocks, Dr. Tony Kiang, Dr. Sherif Mahmoud & Dr. Patrick Mayo
Pharmacogenetics
Studies how variation in one single gene influences the response to a single drug.
Researchers: Dr. Dion Brocks, Dr. Tony Kiang, Dr. Sherif Mahmoud & Dr. Patrick Mayo
Pharmacogenomics
Studies how all the genes that comprise the genome can influence drug responses through pharmacokinetic and pharmacodynamics mediated effects.
Researchers: Dr. Patrick Mayo & Dr. Tony Kiang
Pharmacokinetics
Studies what the body does to a drug. This field deals with the movement of a drug over time into, through, and out of the body via the processes of absorption, distribution, metabolism, excretion, and transport.
Researchers: Dr. Dion Brocks, Dr. Neal Davies, Dr. Fakhreddin Jamali, Dr. Tony Kiang, Dr. Sherif Mahmoud & Dr. Patrick Mayo
Pharmacometrics
An emerging science that quantifies drug, disease, and clinical trial information for drug development. Originally focusing on concentration-effect, does-effect, and PKPD relationships. It has expanded to develop disease models and quantitative relationships between biomarkers and clinical response.
Researchers: Dr. Patrick Mayo, Dr. Dion Brocks & Dr. Tony Kiang
Pharmacology & Toxicology
Researchers: Dr. Khaled Barakat, Dr. Ayman El-Kadi, Dr. Fakhreddin Jamali, Dr. Tony Kiang, Dr. John Seubert & Dr. Arno Siraki
Translational Pharmacology
Researchers: Dr. Tony Kiang