Diaz Carvallo, F.

Cytolytic Vaginosis: A Systematic Scoping Review (work in progress)
Fabiola Diaz Carvallo, MD; Suzwant Gill MD; Sandy Campbell, MLS; Roni Kraut, MD, CCFP.

Context: Vulvovaginitis can significantly impact a women's quality of life. The common differential includes bacterial vaginosis, candidiasis and trichomoniasis. Cytolytic vaginosis, a little known condition, not currently reported by the laboratory, should also be considered. It occurs due to an overgrowth of lactobacilli, with symptoms that mirror candidiasis, but with a distinctly different treatment. It has been estimated to be the cause of 2 - 7% of cases of vulvovaginitis and upwards of 30% of recurrent cases. Objective: To review the published literature on cytolytic vaginosis, determine what has been studied and identify areas where further research is warranted.

Design: PRISMA-ScR methods were followed. A medical librarian searched Prospero, Wiley Cochrane Library, Ovid Embase, Ovid Medline, EBSCO CINAHL, ProQuest Dissertations and Theses Global, and SCOPUS, from inception to April 4, 2019. Studies were included in the review if they pertained to cytolytic vaginosis. Data extracted will include year published, location of study, journal, type of study, focus of study, and study findings. Two independent reviewers will screen studies and extract data.

Results: Preliminary results of the literature search and reference review include 401 unique papers, with 55 meeting the inclusion criteria. Further results of study selection and data extraction will be available at the time of presentation.

Conclusion: The results will inform clinicians on what is known about cytolytic vaginosis, provide guidance to researchers on future areas of study, and further the discussion of reporting cytolytic vaginosis results on routine vaginal specimens.