Neustaedter, C.

"What was in that food?!": A scoping review of risk factors for infection with antimicrobial-resistant Campylobacter
Neustaedter, C.M., Reid-Smith, R.J., MacKinnon, M.C., Carson, C.A., Murphy, C.P., Chapman, B., & Otto, S.J.G.

Campylobacter, a leading cause of acute diarrheic illness around the world, has developed resistance to antimicrobials important for human medicine. Infection with antimicrobial-resistant (AMR) Campylobacter is an important public health concern as it may be linked with increased severity of illness and risk of death. Arising from this, there is a need to better understand potential risk factors for these infections. The objective of this study was to perform a scoping review of factors associated with human infection with AMR Campylobacter.

The scoping review followed the methods described in the Joanna Briggs Institute Reviewer's Manual and PRISMA Scoping Review reporting guidelines. Criteria for inclusion were English-language publications investigating humans with an AMR-Campylobacter infection (resistant to macrolides, tetracyclines, and/or quinolones) that reported factor(s) that may be potentially linked with the infection (e.g., food sources, prior antimicrobial use). The search was completed in ProQuest® AGRICOLA, CAB Abstracts® and Global Health®, Ovid EMBASE®, Scopus®, and Ovid MEDLINE®. Grey literature sources were the World Health Organization's Global Index Medicus, the first 250 relevance-sorted Google Scholar results, and the Bielefield Academic Search Engine. Primary screening (title and abstract) and secondary screening (full text) were completed independently by two reviewers using Distiller SR®. Extracted data will include characteristics of the studies and study participants, and a description of and results associated with the reported factors.

The review retrieved 8739 articles from the five academic databases after de-duplication in Mendeley®. Grey literature sources were not yet searched at the time of submission. Results of article screening and data extraction will be available for presentation in November.

The information from this scoping review will identify gaps in the literature, help to focus future research, be the foundation for future quantitative modeling, and most importantly start the process of organizing the puzzle that is AMR in human Campylobacter infections.