Faculty and Staff

Michael Hawkes

My research interests lie at the interface of basic and clinical science, and my career ambition is to translate state-of-the-art scientific findings to clinically relevant strategies for the improvement of outcomes in global pediatric infections.

I have led a randomized controlled trial of a novel adjunctive treatment for severe malaria, inhaled nitric oxide, in Uganda. I have conducted a prospective cohort study in Uganda of biomarkers of morbidity and mortality in children with acute febrile illness. I have been involved in several projects describing biomarkers of critical host pathways that can predict outcome at admission in pediatric malaria, adult sepsis, leptospirosis, and dengue virus infection. Such tools could provide a potentially powerful approach to assist resource-strapped practitioners in developing countries to allocate scarce resources to children who need them most. 

Thus, my career in translational research will aim to accelerate discovery to impact in terms of patient outcomes, applying principles of infectious disease pathogenesis to identify innovative diagnostic strategies and potential therapeutic targets. This program of research is grounded within a global ethical framework, which sees the world as increasingly interconnected and implicated in the concerns of vulnerable paediatric populations worldwide.


Degrees

PhD, University of Toronto, 2012
MD, University of Alberta, 2001
Bachelor of Engineering, McGill University, 1997


Awards

Post-Doctoral Fellowship, CIHR, 2012-2013
John Leyerle-CIFAR Prize for Interdisciplinary Research, University of Toronto, 2012
Clinician-Scientist Training Award, CIHR, 2006-2012


Publications

Hawkes M, Opoka RO, Namasopo S, Miller C, Thorpe KE, Lavery JV, Conroy AL, Liles WC, John CC, Kain KC. Inhaled Nitric Oxide for the Adjunctive Therapy of Severe Malaria: Protocol for a Randomized Controlled Trial. Trials. 2011 Jul 13

Erdman LK, Dhabangi A, Musoke C, Conroy AL, Hawkes M, Higgins S, Rajwans N, Wolofsky KT, Streiner DL, Liles WC, Cserti-Gazdewich CM, Kain KC. Combinations of host biomarkers predict mortality among Ugandan children with severe malaria: a retrospective case-control study. PLoS One. 2011 Feb 25;6(2)

Hawkes M, Katsuva JP, Masumbuko CK. Use and limitations of malaria rapid diagnostic testing by community health workers in war-torn Democratic Republic of Congo.  Malaria Journal 2009

Hawkes M, Li X, Crockett M, Diassiti A, Finney C, Min-Oo G, Liles WC, Liu J, Kain KC. CD36 deficiency attenuates experimental mycobacterial infection. BMC Infect Dis. 2010 Oct 15

Hawkes M, Li X, Crockett M, Diassiti A, Conrad Liles W, Liu J, Kain KC. Malaria exacerbates experimental mycobacterial infection in vitro and in vivo. Microbes Infect. 2010 Oct;12(11):864-74. Epub 2010 Jun 11.


Current Projects

Solar Powered Oxygen Delivery
Principal Investigator
funded by Grand Challenges Canada (Stars in Global Health)

A fingerprick blood test to replace the chest x-ray
Principal Investigator
funded by Grand Challenges Canada (Stars in Global Health)