Collaborative Orthopaedic Research (CORe)

Joint Preservation and Regeneration

The Joint Preservation and Regeneration research group consists of laboratories aimed to preserve and regenerate tissue from various joints for the purpose of treating joint injuries and diseases such as osteoarthritis. 

Objectives

The primary objectives of this group are to restore joint health by developing novel tissue engineered structures or preserving biologic tissues to be used for implantation or transplantation in damaged joints. The tissues within joints such as articular cartilage and meniscus tend to have a poor capacity to heal. When injury occurs, the joint will progress to degenerative changes if it cannot heal itself, resulting in osteoarthritis with expectant pain, loss of joint motion and loss of joint function. This can severely impact quality of life for these patients. By enabling repair of these joint tissues by various modalities, we may be able to help the joint heal properly and regain normal function thereby improving the quality of life of people with significant joint injuries. 

Our members are cell biologists, biochemists, engineers, orthopedic surgeons and prosthodontists. 

Joint Preservation and Regeneration involves two sub-groups:

  1. Cartilage Cryopreservation
    Focused on preserving cells at subzero temperatures for long-term storage. 
  2. Stem Cells and Joint Tissue Engineering
    Focused on generating joint tissue by using stem and native cells.