Any changes to an approved protocol must be reviewed and approved by the Animal Care and Use Committee before being implemented. Examples of changes requiring an amendment before implementation include additions of animal numbers, new species, new procedures or additional instances of procedures (i.e. increased number of samples to be taken), new drugs or other agents, unapproved or unexpected levels of pain, distress, or mortality.
The ACUC recognizes that in a research environment, unforeseen circumstances may arise. In this case, an emergency/provisional approval of some types of amendments such as changes to anesthetics or analgesics may be provided by a Veterinarian following contact (phone or email) by one of the research team members, and can be documented by the Veterinarian in the PAM Log within the ARISE system. Appropriate documentation in the form of an Amendment submission must follow in a timely fashion.