David Wishart



Biological Sciences

Dr. Wishart is cross appointed with the Department of Computing Science and the NRC's National Institute for Nanotechnology (NINT).  Dr. Wishart's research interests are very broad, touching on areas relating to nanobiology, genonics, proteomics, metabolomics, bioinformatics and systems biology.  His particular interests lie in developing novel methods or improved experimental techniques to facilitate the understanding of biological systems at the molecular (or nano) scale.  Among the areas being actively pursued in Dr. Wishart's lab are:

  • the development of novel bioinformatics software for rapid bacterial annotation;
  • synthetic biology (the engineering of novel organisms or novel proteins),
  • protein structure determinatinon (via NMR spectroscopy),
  • protein structure prediction,
  • prion structure and dynamics; and
  • metabolomics and metabolite profiling.Methods and techniques used in the lab include NMR spectroscopy, MS spectrometry, high pressure liquid chromatography, molecular biology, protein engineering, molecular modeling and computational biology.  The systems being studied include viruses (picorna and pox viruses), bacteria (E. coli), murine prions (hamster and mouse) and human biofluids (blood and urine).