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Derrick L.J. Clive, PhD, DSc

Professor

Science

Chemistry

About Me

B.Sc. Imperial College
Ph.D. Imperial College (Professor D. H. R. Barton)
Postdoctoral Fellow, Harvard (Professor R. B. Woodward)
Medal of University of Helsinki (1989)
Alfred Bader Award in Organic Chemistry (2002)
Fellow of The Chemical Institute of Canada (2002)
R. U. Lemieux Award (2010)
Fellow of the Royal Society of Chemistry (UK) (2017)

Research

My field of research is Synthetic Organic Chemistry - especially as applied to pharmaceutically relevant compounds, and several types of project within this area are being studied in my group:

  • The synthesis of structurally complex natural products that have important biochemical and medicinal properties.
  • The development of new strategy and methodology for making complicated structures.

A brief formula outline of a few topics within these areas is shown below. The synthetic targets that are being examined are relevant to the treatment of heart disease (e.g., CP-225,917), or they show antitumor activity (CP-225,917, MPC1001, the otteliones), or have potential as drugs to control inflammatory diseases and metastasis (halichlorine).

The methodology program involves exploration of the flourishing area of radical cyclization, which has become an extremely useful technique in synthetic organic chemistry, and the formation of cyclic compounds by intramolecular conjugate displacements.

Synthetic Targets:



Methodology: