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Selected Publication

Refereed Papers

S. Zhang, G. Wang, X. Lin, H. Jennissen, M. Chatzinikolaidou, H. Uludag. Polyethylenimine-coated albumin nanoparticles for BMP-2 Delivery. Biotech. Prog (2008) in press.

G. Wang, H. Uludag. Recent developments in nanoparticle-based drug delivery and targeting systems. Exp. Op. Drug Del. (2008) in press.

C. Hsu, H. Uludag. Effect of size and topology of DNA molecules on intracellular delivery with non-viral gene carriers. BMC Biotech. (2008) 8: 23.

B.A. Clements, V. Incani, C. Kucharski, B. Ritchie, A. Lavasanifar, H. Uludag. A comparative evaluation of poly-L-lysine-palmitic acid and LipofectamineTM 2000 for plasmid delivery to bone marrow stromal cells. Biomat. (2007) 28: 4693-4704.

S. Zhang, J.E.I. Wright, N. Ozber, H. Uludag. Interactions of cationic polymers and their bisphosphonate derivatives with hydroxyapatite. Macromol. Biosci. (2007) 7: 656-670.

L.-L. Farrell, J. Pepin, C. Kucharski, X. Lin, Z. Xu, H. Uludag. A comparison of the effectiveness of cationic polymers poly-L-lysine (PLL) and polyethyleneimine (PEI) for non-viral delivery of plasmid DNA to bone marrow stromal cells. Eur. J. Pharmaceut. Biopharmaceut. (2007) 65: 388-397.

X.-B. Xiong, A. Mahmud, H. Uludag, A. Lavasanifar. Conjugation of arginine-glycine-aspartic acid peptides to poly(ethylene-oxide)-b-poly(e-caprolactone) micelles for enhanced intracellular drug delivery to metastatic tumor cells. Biomacromol. (2007) 8: 874-884.

M. Abbasi, H. Uludag, V. Incani, C. Olson, X. Lin, D. Rutkowski, A. Ghahary, M. Weinfeld. Palmitic acid-modified poly-l-lysine for non-viral delivery of plasmid DNA to skin fibroblasts. Biomacromol. (2007) 8: 1059-1063.

M. Varkey, C. Kucharski, M.R. Doschak, S.R. Winn, E.J. Brochmann, S. Murray, J.R. Matyas, R.F. Zernicke and H. Uludag. Osteogenic response of bone marrow stromal cells form normal and ovariectomized rats treated with low dose of bFGF. Tissue Eng. (2007) 13: 809-817.

V. Incani, E. Tunis, B.A. Clements, C. Olson, C. Kucharski, A. Lavasanifar, H. Uludag. Palmitic acid substitution on cationic polymers for effective delivery of plasmid DNA to bone marrow stromal cells. J. Biomed. Mat. Res. (2007) 81: 493-504.

S. Zhang, G. Bansal, H. Uludag. ‘Magic Bullets’ for bone diseases: progress in rational design of bone therapeutics based on bisphosphonate targeting. Chem. Soc. Rev. (2007) 36: 507-531.

M. Varkey, C. Kucharski, T. Haque, W. Sebald, H. Uludag. In vitro osteogenic response of rat bone marrow cells to bFGF and BMP-2. Clin. Orthop. Rel. Res. (2006) 443: 113-123.

X. Jiang, J. Bai, S.A. Gittens, W. Sebald, H. Uludag. Alkaline phosphatase response of bone marrow stromal cells on thermoreversible polymers. Mat.-wiss. u. Werkstofftech (2006) 37: 462-468.

B. Açan Clements, J. Bai, C. Kucharski, L.-L. Farrell, A. Lavasanifar, B. Ritchie, A. Ghahary, H. Uludag. RGD-conjugation to polyethyleneimine does not improve DNA delivery to bone marrow stromal cells. Biomacromol. (2006) 7: 1481-1488.

S.A. Gittens, G. Bansal, C. Kucharski, M. Borden, H. Uludag. Imparting mineral affinity to fetuin by bisphosphonate conjugation: a comparison of three bisphosphonate conjugation schemes. Molecular Pharmaceutics (2005) 2: 392-406.

J.E.I. Wright, S.A. Gittens, G. Bansal, P.I. Kitov, D. Sindrey, C. Kucharski, H. Uludag. A comparison of mineral affinity of bisphosphonate-protein conjugates constructed with disulfide and thioether linkages. Biomaterials (2005) 27: 769-784.

S. Zhang, G. Bansal, J.E.I. Wright, P. Cho, H. Uludag. Cleavage of disulfide-linked fetuin-bisphosphonate conjugates with three physiological thiols. Biomacromolecules (2005) 6: 2800-2808.

G. Bansal, J.E.I. Wright, C. Kucharski, H. Uludag. A dendritic tetra(bisphosphonic acid) for improved targeting of proteins to bone. Angew. Chem. Int. Ed. (2005) 44:3710-3714.

E. Smith, J. Yang, L. McGann, W. Sebald, H. Uludag. RGD-grafted thermoreversible polymers to facilitate attachment of BMP-2 responsive C2C12 cells. Biomaterials (2005) 26: 7329-7338.

H. Uludag, P. Santerre, G. Laroche, M. Filiaggi. Preface: Special issue of Biomaterials dedicated to Canadian biomaterials research. Biomaterials (2005) 26: 7207-7208.

G. Bansal, J.E.I. Wright, S. Zhang, R.F. Zernicke, H. Uludag. Imparting mineral affinity to proteins with thiol-labile disulfide linkages. J. Biomed. Mat. Res. (2005) 74A:618-628.

T. Haque, H. Uludag, R.F. Zernicke, S.R. Winn, W. Sebald. Bone marrow cells from normal and ovariectomized rats respond differently to basic Fibroblast Growth Factor and Bone Morphogenetic Protein-2 treatment in vitro. Tissue Eng. (2005) 11: 634-644.

A. Jalil, H. Uludag. Hydrogels of thermoreversible comb-polymers exhibit increased resistance for dissolution. Mat. Sci. & Eng. (Mat.-wiss. U. Werkstofftech.) (2004) 35: 972-979.

J. Bai, B. Acan, A Ghahary, B. Ritchie, V. Somayaji, H. Uludag. Polyethyleneimine/ Arginine-Glycine-Aspartic Acid conjugates prepared by N-succinimidyl 3-(2-pyridyldithio)propionate : an investigation of peptide coupling and conjugate stability . J. Polym. Sci. Polym. Chem. (2004) 42: 6143-6156.

G. Bansal, S. Gittens, H. Uludag. A di(bisphosphonic acid) for protein coupling and targeting to bone. J. Pharm. Res. (2004) 93: 2788-2799.

S.A. Gittens, K. Bagnall, J.R. Matyas, R. Löbenberg, H. Uludag. Imparting bone mineral affinity to osteogenic proteins through heparin-bisphosphonate conjugates. J. Cont. Rel. (2004) 98: 255-268.

 

S.A. Gittens, G.R. Wohl, R.F. Zernicke, J.R. Matyas, P. Morley, H. Uludag. Systemic bone formation with weekly PTH administration in ovariectomized rats. J. Pharm. Pharmaceut. Sci. (2004) 7: 27-37.

S.A. Gittens, PI Kitov, JR Matyas, R Loebenberg, H Uludag. Impact of tether length on the bone mineral affinity of protein-bisphosphonate conjugates. Pharm. Res. (2004) 21: 608-616.

K. Sarkhosh, E.E. Tredget, H. Uludag, R.T. Kilani, A. Karami, Y. Li, T. Iwashina, A. Ghahary. Temperature-sensitive polymer-conjugated IFN-? induces the expression of IDO mRNA and activity by fibroblasts populated in collagen gel (FPCG). J. Cell. Physiol. (2004) 201: 146-154.

H. Uludag, E. Smith, L.E. McGann, J. Yang. Osteogenic response of C2C12 cells on thermoreversible polymers. Mat. Sci. & Eng. (Mat.-wiss. U. Werkstofftech.) (2003) 34: 1076-1083.

E. Smith, J. Bai, C. Oxenford, J. Yang, R. Somayaji, H. Uludag. Conjugation of arginine-glycine-aspartic acid peptides to thermoreversible N-isopropylacrylamide polymers. J. Polym. Sci. A. Polym. Chem. (2003) 41: 3989-4000.

K. Sarkhosh, E.E. Tredget, A. Karami, H. Uludag, T. Iwashina, R.T. Kilani, A. Ghahary. Immune cell proliferation is suppressed by interferon-? induced Indoleamine 2,3-dioxygenase expression of fibroblasts populated in collagen gel (FPCG). J. Cell. Biochem. (2003) 90: 206-217.

K. Sarkhosh, E.E. Tredget, Y. Li, R.T. Kilani, H. Uludag, A. Ghahary. Proliferation of PBMC is suppressed by the indoleamine 2,3-dioxygenase expression of IFN-?-treated skin cells in a coculture system. Wound Repair and Regeneration (2003) 11: 337-345.

S. Gittens, J.R. Matyas, R. Zernicke, H. Uludag. Imparting bone affinity to glycoproteins through the conjugation of bisphosphonates. Pharm. Res. (2003) 20: 978-987.

H. Uludag, J. Yang. Targeting systemically administered proteins to bone by bisphosphonate conjugation. Biotech. Prog. (2002) 18: 604-611.

T.J. Gao, N.A. Kousinioris, J.M. Wozney, S. Winn, H. Uludag. Synthetic thermo-reversible polymers are compatible with osteoinductive activity of rhBMP-2. Tissue Eng. (2002) 8: 429-440.

T.J. Gao, H. Uludag. Effect of molecular weight of thermoreversible polymer on in vivo retention of rhBMP-2. J. Biomed. Mat. Res. (2001) 57: 92-100.

T. Gao, N. Kousinioris, S.R Winn, J.M. Wozney, H. Uludag. Enhanced in vivo retention of rhBMP-2 by thermoreversible polymers. Mat.-wiss. u. Werkstofftech (2001) 32: 953-961.

H. Uludag, B. Norrie, N. Kouisinioris, T.J. Gao. Engineering temperature-sensitive poly(N-isopropylacrylamide) polymers as carriers of therapeutic proteins. Biotech. Bioeng. (2001) 73: 510-521.


Invited Reviews

S. Zhang, G. Bansal, H. Uludag. ‘Magic Bullets’ for bone diseases: progress in rational design of bone therapeutics based on bisphosphonate targeting. Chem. Soc. Rev. (2006) in press.

S. Gittens, G. Bansal, R.F. Zernicke, H. Uludag. Designing proteins for bone targeting. Adv. Drug Del. Rev. (2005) 57: 1011-1036.

S. Gittens, G. Bansal, R.F. Zernicke, H. Uludag. Designing protein-seeking proteins. Adv. Drug Del. Rev. (2005) in press.

M. Varkey, S. Gittens, H. Uludag. Growth Factor delivery for bone tissue repair: An update. Exp. Op. Drug Del. (2004) 1: 19-36.

H. Uludag. Bisphosphonates as a foundation for drug delivery to bone. Curr. Pharm. Design (2002) 8: 1929-1944.

H. Uludag, T.J. Gao, T. Porter, W. Friess, J.M. Wozney. Delivery systems for BMPs: factors contributing to protein retention at an application site. J. Bone Joint Surg. Am. (2001) 83-A Suppl 1(Pt 2): 128-135.

S. Gittens, H. Uludag. Growth factor delivery for bone tissue engineering. J. Drug Targeting (2001) 9: 407-429.

H. Uludag, P. De Vos, P. Tresco. Technology of mammalian cell encapsulation. Adv. Drug Del. Rev. (2000) 42: 29-64.


Book Chapters

X. Xiong, H. Uludag, A. Lavasanifar. Block copolymer synthesis for nanoscale drug and gene delivery. In Biotechnology: Pharmaceutical Aspects. Nanotechnology in Drug Delivery. M.M. de Villiers, G.S. Kwon (Eds) Springer Science (2007) in press.

S.R. Winn, J. Mitchell, H. Uludag. In vitro testing of biomaterials. In An Introduction to Biomaterials. S.A. Guelcher, J.O. Hollinger (Eds), CRC Press (2005) 63-79.

J. Wright, L. Zhao, P. Choi, H. Uludag. Simulating hydroxyapatite binding of bone-seeking bisphosphonates. In Biomaterials: From Molecules to Engineered Tissues (Adv. Exp. Med. Biol., Vol. 553). N. Hasirci and V. Hasirci (Eds) Kluwer Academic/Plenum Publishers. NY, USA (2004) 139-148.

B. Norrie, A. Jalil, J. Lakey, R.V. Rajotte, H. Uludag. In-situ crosslinking thermoreversible polymers for cell entrapment. In Biomaterials: From Molecules to Engineered Tissues (Adv. Exp. Med. Biol., Vol. 553). N. Hasirci and V. Hasirci (Eds) Kluwer Academic/Plenum Publishers. NY, USA (2004) 19-28.

T.J. Gao, H. Uludag. Injectable formulation of biomaterials as a delivery system for BMP. In Advances in Skeletal Reconstruction Using Bone Morphogenetic Proteins. T.S. Lindholm (Ed), World Scientific Publishing Co., River Edge, NJ (2002) 125-141.

H. Uludag, X.-D. Fan. Synthesis and characterization of thermoreversible, protein-conjugating copolymers based on N-isopropylacrylamide. In Drug Delivery in the 21st Century, K. Park and R. Msryn (Eds), Vol. 752, ACS Publishers, Washington, DC (2000) 253-262.

 
 

 

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