Uludag lab is equipped with facilities to synthesize and characterize small organic molecules and polymeric materials. A synthesis workstation with the capacity to synthesize 24-96 compounds at a time is available to create molecular libraries.
Local Nuclear Magnetic Resonance (NMR) facilities are available to characterize the structure of the synthesized entities. Routinely used instruments include UV/Visible spectrophotometer (for polymer composition, polymer reactivity, protein assays, etc.), a Waters High Pressure Liquid Chromatography with a photodiode array detector (for analysis of protein conjugates, molecular weight distribution of polymers), and a Precision Laser Light Scattering Instrument (for analysis of molecular sizes and hydrodynamic radius of polymers and proteins in solution). Access to local surface plasmon resonance instruments is possible to investigate biomolecular interactions.
Tissue Culture
A tissue culture facility is available for routine cultivation of cell lines and other cell types. Facilities to obtain primary cells from small animal models under sterile conditions have been established. Cell culture facilities are used to evaluate the biological performance of biomaterials and biological molecules - this is critical before animal experimentation. Tissue processing equipment is available for histological analysis of hard and soft tissues.
Radioactivity Work
A radioactive lab is functional for protein labeling to study biodistribution and targeting of therapeutic agents in animals. Animal studies are carried out at the Animal Health Services of the U. of Alberta. When necessary, imaging (microCT) and quantitative radiography (DEXA) instruments are utilized at the U. of Calgary and other facilities in N. America.
Collaboration
Active research collaborations have been established to complement the research activities in Uludag Lab. The Bone Regeneration Project is being carried out in collaboration with Dr. John Matyas (Department of Cell Biology and Anatomy, U. of Calgary), Dr. Ronald Zernicke (Faculty of Kinesiology, U. of Calgary) and Dr. Shelley Winn (Oregon Health Sciences University, Portland, OR). A collaboration on wound healing and skin regeneration is under way with Dr. Aziz Ghahary (Department of Surgery, U. of British Columbia). Studies on DNA delivery are carried out in collaboration with Dr. B. Ritchie (Department of Hematology, U. of Alberta) and Dr. A. Lavasanifar (Faculty of Pharmacy and Pharmaceutical Sciences, U. of Alberta). Numerous other colleagues are consulted on a regular basis depending on the project needs and the appropriate supervision of graduate students.
Laboratory Equipment Slideshow
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526 Chemical and Materials Engineering Building
Department of Chemical and Materials Engineering, Faculty of Engineering,
University of Alberta, Edmonton
T6G 2G6
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A radioactive lab is functional for protein labeling to study biodistribution and targeting of therapeutic agents in animals. Animal studies are carried out at the Animal Health Services of the U. of Alberta. When necessary, imaging (microCT) and quantitative radiography (DEXA) instruments are utilized at the U. of Calgary and other facilities in N. America.