The BME Seminar Series features presentations surrounding the field of Biomedical Engineering.
Next Upcoming Seminar:
Date: 2018 May 30
Time: Noon - 1PM
Location: 1-075 RTF
Presentation Topic: Development and Application of Quantitative Gradient-Echo MRI Techniques for Assessment of Iron and Myelin in the Multiple Sclerosis Brain
Presenter: Ahmed Elkady, PhD Candidate
Abstract: Multiple Sclerosis (MS) is a progressive autoimmune and neurodegenerative disease of the Central Nervous System that results in demyelination and neuronal/axonal loss. Along with clinical evaluation, Magnetic Resonance Imaging (MRI) is the gold standard modality for diagnosing and monitoring MS, which has been conventionally carried out using T1 and T2-weighted pulse sequences. Gradient-echo T2*-weighted has been recently demonstrated as a sensitive predictor of MS disability and cognitive decline; however, more research is needed to implement quantitative gradient-echo (qGE) based techniques into clinical practice and drug trials. The purpose of this thesis was to develop technical MRI innovations and study research applications to further the field of qGE MRI of MS. The main clinical hypothesis was that qGE MRI methods may serve as a biomarker of disease progression in MS. This hypothesis was tested in one cross-sectional study and two longitudinal studies of MS subjects compared to age-matched controls, where we related MRI findings to clinical outcomes. We investigate the limitations of using Quantitative Susceptibility (QS) mapping for analyzing lesions in MS, and demonstrate that further work is needed to utilize QS for analyzing QS lesion contrast. We also explore the use of field-of-view (FOV) restriction to accelerate MRI acquisitions used for QS mapping, and demonstrate the sensitivity of QS accuracy to FOV changes. Using combined R2* and QS mapping, we present novel qGE cross-sectional and longitudinal analysis techniques, and demonstrate the correlation of qGE to clinical measures. Thus, we demonstrate that qGE is indeed a valuable tool that may be used for monitoring MS disease progression.
The BME Seminar Series features presentations by current graduate students as part of the BME 600A/B courses (Fall/Winter terms). Each of the seminars offers a glimpse into biomedical research taking place at our university.
Details about the next series will be posted soon!
Time & Location:
RTF Table Tennis Tourney April 2018!
Want to play table tennis (ping-pong)?
Want to meet other people from RTF/Imaging Research?
Why not kill 2 birds with 1 stone?
If you're interested, e-mail Prayash and Kevin (or let them know in person)
Update 4 April 2018:
The paddles are here, the table is set, and the nets are waiting!
Tentatively, we are planning the tournament day during the week of April 23-27, but please use our Table Tennis Tourney Doodle Poll to indicate which day works best for you. The tourney bracket will include everyone who signs up.
We will also have a practice session some time prior to the tournament. We will use this to go over the rules, wipe some of the rust off, and make sure everyone is on the same page! Everyone who is interested can fill out the Practice Day Doodle Poll.
Keep a look out for an e-mail next Friday (April 13) confirming the date and time!
Please feel free to forward this to anyone in BME who may not have received it.
Prayash - room 1-086 RTF
Kevin - room 1-113 RTF